| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Candriam S.C.A. | 925,332 | 1,696,040 | +770,708 | 0.11 | 0.17 | +0.05 | buy |
| Prosight Management, LP | 770,000 | 1,200,000 | +430,000 | 2.95 | 4.52 | +1.57 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 724,563 | 1,014,606 | +290,043 | 2.69 | 2.89 | +0.21 | buy |
| Hood River Capital Management LLC | 2,354,285 | 2,564,279 | +209,994 | 0.55 | 0.41 | -0.14 | buy |
| Rhenman & Partners Asset Management AB | 379,250 | 560,250 | +181,000 | 1.09 | 1.16 | +0.06 | buy |
| Granahan Investment Management, LLC | 306,321 | 446,988 | +140,667 | 0.35 | 0.35 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 214,807 | 342,883 | +128,076 | 0.17 | 0.21 | +0.05 | buy |
| DAFNA Capital Management LLC | 217,355 | 335,255 | +117,900 | 1.16 | 1.40 | +0.24 | buy |
| Aberdeen Group plc | 286,969 | 372,766 | +85,797 | 0.01 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 66,340 | 140,797 | +74,457 | 0.05 | 0.08 | +0.03 | buy |
| Headlands Technologies LLC | 25,392 | 56,227 | +30,835 | 0.07 | 0.13 | +0.06 | buy |
| TEMA ETFS LLC | 58,348 | 72,212 | +13,864 | 0.09 | 0.05 | -0.04 | buy |
| Harbour Capital Advisors, LLC | 13,650 | 20,650 | +7,000 | 0.06 | 0.09 | +0.03 | buy |
| APIS CAPITAL ADVISORS, LLC | 550,000 | 556,000 | +6,000 | 1.98 | 1.18 | -0.80 | buy |
| China Universal Asset Management Co., Ltd. | 15,652 | 14,102 | -1,550 | 0.03 | 0.02 | -0.01 | sell |
| MPM BioImpact LLC | 1,340,733 | 1,333,523 | -7,210 | 2.42 | 1.78 | -0.64 | sell |
| SECTOR GAMMA AS | 286,007 | 241,739 | -44,268 | 1.58 | 1.15 | -0.43 | sell |
| Eversept Partners, LP | 2,885,622 | 2,798,210 | -87,412 | 3.55 | 3.17 | -0.38 | sell |
| PFM Health Sciences, LP | 245,021 | 118,422 | -126,599 | 0.52 | 0.22 | -0.30 | sell |