| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Iron Triangle Partners LP | 0 | 973,057 | +973,057 | 0.00 | 2.40 | +2.40 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,397 | 736,148 | +711,751 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 984,258 | 1,655,052 | +670,794 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,335,353 | 4,926,984 | +591,631 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 538,714 | +538,714 | 0.00 | 0.03 | +0.03 | buy |
| Sofinnova Investments, Inc. | 1,075,786 | 1,608,540 | +532,754 | 1.30 | 2.26 | +0.96 | buy |
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.88 | +0.88 | buy |
| Commodore Capital LP | 0 | 318,851 | +318,851 | 0.00 | 0.51 | +0.51 | buy |
| Schonfeld Strategic Advisors LLC | 471,475 | 785,644 | +314,169 | 0.08 | 0.15 | +0.06 | buy |
| TWO SIGMA ADVISERS, LP | 151,452 | 455,852 | +304,400 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,535,055 | 1,778,548 | +243,493 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 143,266 | 346,862 | +203,596 | 0.03 | 0.08 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 535,938 | 718,552 | +182,614 | 0.03 | 0.04 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 178,500 | +178,500 | 0.00 | 0.40 | +0.40 | buy |
| CITIGROUP INC | 162,406 | 324,929 | +162,523 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,664,306 | 1,815,758 | +151,452 | 0.00 | 0.00 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 746,293 | 894,993 | +148,700 | 3.07 | 2.82 | -0.25 | buy |
| FRANKLIN RESOURCES INC | 1,352,905 | 1,495,705 | +142,800 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 109,827 | +109,827 | 0.00 | 0.12 | +0.12 | buy |
| Nantahala Capital Management, LLC | 365,259 | 465,259 | +100,000 | 0.79 | 1.08 | +0.29 | buy |
| Propel Bio Management, LLC | 0 | 83,259 | +83,259 | 0.00 | 1.15 | +1.15 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 79,100 | +79,100 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 320,911 | 396,878 | +75,967 | 0.23 | 0.33 | +0.10 | buy |
| Knott David M Jr | 0 | 65,475 | +65,475 | 0.00 | 0.55 | +0.55 | buy |
| Graham Capital Management, L.P. | 14,936 | 80,186 | +65,250 | 0.01 | 0.05 | +0.04 | buy |
| NORTHERN TRUST CORP | 678,105 | 741,827 | +63,722 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 11,801 | 75,337 | +63,536 | 0.04 | 0.17 | +0.13 | buy |
| PFM Health Sciences, LP | 595,523 | 658,694 | +63,171 | 0.77 | 0.78 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 174,144 | 237,006 | +62,862 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,250,948 | 1,310,073 | +59,125 | 0.01 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 8,054 | 66,964 | +58,910 | 0.02 | 0.14 | +0.12 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 577,022 | 635,207 | +58,185 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 738,589 | 784,811 | +46,222 | 2.26 | 2.29 | +0.03 | buy |
| NVWM, LLC | 0 | 42,962 | +42,962 | 0.00 | 0.28 | +0.28 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 772,964 | 812,964 | +40,000 | 3.10 | 3.13 | +0.03 | buy |
| Qube Research & Technologies Ltd | 57,361 | 93,889 | +36,528 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 166,033 | 197,024 | +30,991 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 34,500 | 65,000 | +30,500 | 0.67 | 2.96 | +2.29 | buy |
| Engineers Gate Manager LP | 16,240 | 42,487 | +26,247 | 0.01 | 0.03 | +0.02 | buy |
| Candriam S.C.A. | 1,021,032 | 1,045,032 | +24,000 | 0.15 | 0.16 | +0.01 | buy |
| Scientech Research LLC | 0 | 23,520 | +23,520 | 0.00 | 0.30 | +0.30 | buy |
| JANUS HENDERSON GROUP PLC | 26,447 | 48,948 | +22,501 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 21,519 | +21,519 | 0.00 | 0.18 | +0.18 | buy |
| Sigma Planning Corp | 0 | 19,835 | +19,835 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 29,320 | 48,835 | +19,515 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,983 | 47,575 | +18,592 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,267 | 44,510 | +18,243 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 35,902 | 53,216 | +17,314 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 17,033 | +17,033 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 15,760 | +15,760 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 15,523 | +15,523 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 55,122 | 69,778 | +14,656 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 230,858 | 245,363 | +14,505 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 95,317 | 108,994 | +13,677 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 95,949 | 108,431 | +12,482 | 0.07 | 0.07 | +0.01 | buy |
| ALPS ADVISORS INC | 48,126 | 59,924 | +11,798 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,605 | +10,605 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 9,368 | +9,368 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 0 | 8,956 | +8,956 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 8,058 | 16,338 | +8,280 | 0.03 | 0.05 | +0.02 | buy |
| Swiss National Bank | 142,400 | 150,600 | +8,200 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,924 | 41,913 | +7,989 | 0.00 | 0.00 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 86,175 | 94,065 | +7,890 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 48,458 | 56,275 | +7,817 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 1,471 | 8,636 | +7,165 | 0.03 | 0.18 | +0.15 | buy |
| STEMPOINT CAPITAL LP | 1,094,494 | 1,100,988 | +6,494 | 6.37 | 7.00 | +0.63 | buy |
| JANE STREET GROUP, LLC | 107,066 | 113,528 | +6,462 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,893 | 29,173 | +6,280 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 5,707 | +5,707 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 33,221 | 38,832 | +5,611 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 34,755 | 40,324 | +5,569 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 506,009 | 511,501 | +5,492 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,513 | 20,112 | +4,599 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 8,076 | 12,580 | +4,504 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 16,511 | 20,977 | +4,466 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,126 | 18,292 | +4,166 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 93,067 | 96,833 | +3,766 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,481 | 16,989 | +3,508 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,329 | 14,466 | +3,137 | 0.00 | 0.00 | -0.00 | buy |
| Lighthouse Investment Partners, LLC | 52,199 | 55,297 | +3,098 | 0.08 | 0.06 | -0.02 | buy |
| Crestline Management, LP | 100,649 | 103,710 | +3,061 | 0.20 | 0.23 | +0.03 | buy |
| Quarry LP | 750 | 3,500 | +2,750 | 0.01 | 0.03 | +0.03 | buy |
| OSAIC HOLDINGS, INC. | 0 | 2,692 | +2,692 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,734 | +1,734 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,595 | 7,182 | +1,587 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,546 | 7,858 | +1,312 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,407 | 76,557 | +1,150 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 39,472 | 40,463 | +991 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 7,730 | 8,146 | +416 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,807 | 4,150 | +343 | 0.00 | 0.00 | +0.00 | buy |
| CarsonAllaria Wealth Management, Ltd. | 0 | 218 | +218 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 186 | +186 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 3,748 | 3,924 | +176 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 2,441 | 2,567 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 361 | 485 | +124 | 0.00 | 0.00 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 0 | 107 | +107 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 242 | 314 | +72 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,544,216 | 1,544,287 | +71 | 0.36 | 0.34 | -0.02 | buy |
| NISA INVESTMENT ADVISORS, LLC | 35 | 104 | +69 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 20 | 69 | +49 | 0.00 | 0.00 | +0.00 | buy |