| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 1,075,786 | 1,608,540 | +532,754 | 1.30 | 2.13 | +0.83 | buy |
| TWO SIGMA INVESTMENTS, LP | 535,938 | 718,552 | +182,614 | 0.03 | 0.04 | 0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 746,293 | 894,993 | +148,700 | 3.07 | 2.82 | -0.25 | buy |
| ALGERT GLOBAL LLC | 528,157 | 425,673 | +102,484 | 0.46 | 0.40 | 0.00 | sell |
| Nantahala Capital Management, LLC | 365,259 | 465,259 | +100,000 | 0.47 | 0.63 | +0.16 | buy |
| Granahan Investment Management, LLC | 320,911 | 396,878 | +75,967 | 0.23 | 0.33 | +0.10 | buy |
| ExodusPoint Capital Management, LP | 353,252 | 286,330 | +66,922 | 0.10 | 0.09 | 0.00 | sell |
| Simplify Asset Management Inc. | 11,801 | 75,337 | +63,536 | 0.04 | 0.17 | +0.13 | buy |
| PFM Health Sciences, LP | 595,523 | 658,694 | +63,171 | 0.77 | 0.74 | -0.03 | buy |
| BIT Capital GmbH | 8,054 | 66,964 | +58,910 | 0.02 | 0.12 | +0.10 | buy |
| Parkman Healthcare Partners LLC | 738,589 | 784,811 | +46,222 | 2.26 | 2.29 | +0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 772,964 | 812,964 | +40,000 | 2.69 | 2.72 | +0.03 | buy |
| Lion Point Capital, LP | 34,500 | 65,000 | +30,500 | 0.37 | 0.86 | +0.49 | buy |
| Candriam S.C.A. | 1,021,032 | 1,045,032 | +24,000 | 0.15 | 0.16 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 95,949 | 108,431 | +12,482 | 0.15 | 0.19 | 0.00 | buy |
| ALPS ADVISORS INC | 48,126 | 59,924 | +11,798 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,058 | 16,338 | +8,280 | 0.03 | 0.05 | +0.02 | buy |
| AXIOM INVESTORS LLC /DE | 86,175 | 94,065 | +7,890 | 0.02 | 0.02 | +0.00 | buy |
| PROFUND ADVISORS LLC | 65,182 | 58,247 | +6,935 | 0.06 | 0.05 | 0.00 | sell |
| STEMPOINT CAPITAL LP | 1,094,494 | 1,100,988 | +6,494 | 6.37 | 7.00 | +0.63 | buy |
| Lighthouse Investment Partners, LLC | 52,199 | 55,297 | +3,098 | 0.05 | 0.06 | +0.01 | buy |
| Crestline Management, LP | 100,649 | 103,710 | +3,061 | 0.19 | 0.22 | +0.03 | buy |
| Quarry LP | 750 | 3,500 | +2,750 | 0.01 | 0.03 | 0.00 | buy |
| Woodline Partners LP | 1,544,216 | 1,544,287 | +71 | 0.36 | 0.34 | -0.02 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 196,033 | 196,079 | +46 | 0.13 | 0.13 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 4,657 | 4,359 | -298 | 0.06 | 0.06 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 50,780 | 50,170 | -610 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 17,780 | 15,032 | -2,748 | 0.04 | 0.04 | -0.01 | sell |
| E Fund Management Co., Ltd. | 21,580 | 17,638 | -3,942 | 0.03 | 0.03 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 83,456 | 71,883 | -11,573 | 0.03 | 0.04 | +0.01 | sell |
| Entropy Technologies, LP | 30,571 | 16,590 | -13,981 | 0.12 | 0.04 | -0.08 | sell |
| Rafferty Asset Management, LLC | 403,381 | 373,238 | -30,143 | 0.04 | 0.03 | -0.00 | sell |
| Palo Alto Investors LP | 472,600 | 405,193 | -67,407 | 0.92 | 1.09 | +0.17 | sell |
| DAFNA Capital Management LLC | 742,574 | 659,574 | -83,000 | 3.85 | 3.57 | -0.27 | sell |
| Zimmer Partners, LP | 275,100 | 155,000 | -120,100 | 0.22 | 0.08 | -0.14 | sell |
| Saturn V Capital Management LP | 518,799 | 397,997 | -120,802 | 4.29 | 3.80 | -0.49 | sell |
| Soleus Capital Management, L.P. | 514,000 | 369,000 | -145,000 | 1.23 | 0.77 | -0.46 | sell |
| Eversept Partners, LP | 3,383,244 | 3,133,113 | -250,131 | 6.42 | 4.97 | -1.45 | sell |
| T. Rowe Price Investment Management, Inc. | 2,711,253 | 2,459,235 | -252,018 | 0.04 | 0.04 | -0.00 | sell |
| Avidity Partners Management LP | 3,950,000 | 2,412,500 | -1,537,500 | 3.26 | 2.04 | -1.22 | sell |