| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Eversept Partners, LP | 343,400 | 4,212,270 | +3,868,870 | 0.40 | 5.26 | +4.85 | buy |
| Sofinnova Investments, Inc. | 658,627 | 2,275,223 | +1,616,596 | 0.63 | 1.83 | +1.19 | buy |
| PFM Health Sciences, LP | 206,871 | 926,424 | +719,553 | 0.17 | 0.83 | +0.66 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,381,241 | 1,663,974 | +282,733 | 3.30 | 4.71 | +1.41 | buy |
| Rhenman & Partners Asset Management AB | 232,000 | 433,000 | +201,000 | 0.32 | 0.61 | +0.30 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,022,537 | 1,221,269 | +198,732 | 0.03 | 0.04 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 148,568 | 314,407 | +165,839 | 0.02 | 0.05 | 0.00 | buy |
| Casdin Capital, LLC | 475,000 | 635,000 | +160,000 | 0.42 | 0.64 | +0.22 | buy |
| TWO SIGMA INVESTMENTS, LP | 669,823 | 780,009 | +110,186 | 0.02 | 0.02 | 0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 200,000 | +100,000 | 0.09 | 0.14 | +0.05 | buy |
| ALGERT GLOBAL LLC | 785,632 | 884,600 | +98,968 | 0.25 | 0.27 | 0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,230,400 | 1,309,224 | +78,824 | 3.64 | 3.36 | -0.28 | buy |
| Parkman Healthcare Partners LLC | 526,973 | 594,987 | +68,014 | 0.93 | 0.87 | -0.06 | buy |
| Saturn V Capital Management LP | 988,528 | 1,041,280 | +52,752 | 5.12 | 6.46 | +1.34 | buy |
| GSA CAPITAL PARTNERS LLP | 36,857 | 87,284 | +50,427 | 0.04 | 0.11 | 0.00 | buy |
| Palo Alto Investors LP | 405,193 | 444,367 | +39,174 | 0.83 | 1.04 | +0.21 | buy |
| Aberdeen Group plc | 99,340 | 132,433 | +33,093 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 90,232 | 59,438 | +30,794 | 0.10 | 0.06 | 0.00 | sell |
| Polar Asset Management Partners Inc. | 84,998 | 106,628 | +21,630 | 0.01 | 0.03 | +0.02 | buy |
| Exome Asset Management LLC | 318,900 | 337,198 | +18,298 | 3.17 | 3.71 | +0.54 | buy |
| AlphaQuest LLC | 23,623 | 39,317 | +15,694 | 0.04 | 0.06 | 0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 115,087 | 130,746 | +15,659 | 0.02 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 621,840 | 631,640 | +9,800 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 86,225 | 91,717 | +5,492 | 0.10 | 0.11 | +0.02 | buy |
| E Fund Management Co., Ltd. | 12,603 | 16,031 | +3,428 | 0.01 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 542,002 | 544,502 | +2,500 | 1.82 | 1.90 | +0.08 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 252,000 | 250,000 | +2,000 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 34,548 | 35,481 | +933 | 0.02 | 0.02 | +0.00 | buy |
| Optimize Financial Inc | 11,509 | 12,227 | +718 | 0.11 | 0.11 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,792 | 2,186 | +394 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 147,641 | 147,785 | +144 | 0.14 | 0.08 | -0.05 | buy |
| Washington Trust Advisors, Inc. | 107 | 209 | +102 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 915 | 826 | +89 | 0.00 | 0.00 | 0.00 | sell |
| DnB Asset Management AS | 22,943 | 22,378 | -565 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,099 | 17,121 | -978 | 0.02 | 0.02 | -0.00 | sell |
| AXIOM INVESTORS LLC /DE | 53,224 | 52,204 | -1,020 | 0.01 | 0.01 | +0.00 | sell |
| Inspire Investing, LLC | 30,792 | 27,898 | -2,894 | 0.05 | 0.04 | -0.00 | sell |
| Nebula Research & Development LLC | 76,914 | 72,558 | -4,356 | 0.12 | 0.08 | -0.04 | sell |
| Atom Investors LP | 62,795 | 57,274 | -5,521 | 0.10 | 0.09 | -0.02 | sell |
| Nantahala Capital Management, LLC | 560,532 | 554,503 | -6,029 | 0.32 | 0.27 | -0.05 | sell |
| Rafferty Asset Management, LLC | 178,165 | 171,541 | -6,624 | 0.01 | 0.01 | +0.00 | sell |
| Prosight Management, LP | 620,000 | 609,252 | -10,748 | 2.27 | 2.46 | +0.19 | sell |
| Candriam S.C.A. | 547,165 | 450,435 | -96,730 | 0.04 | 0.03 | -0.01 | sell |
| TWINBEECH CAPITAL LP | 355,900 | 255,832 | -100,068 | 0.08 | 0.06 | -0.02 | sell |
| Granahan Investment Management, LLC | 905,322 | 549,942 | -355,380 | 0.50 | 0.34 | -0.16 | sell |
| Avidity Partners Management LP | 1,500,000 | 925,000 | -575,000 | 1.98 | 2.34 | +0.37 | sell |
| STEMPOINT CAPITAL LP | 2,872,601 | 1,598,594 | -1,274,007 | 9.52 | 6.27 | -3.25 | sell |
| Soleus Capital Management, L.P. | 2,492,000 | 816,610 | -1,675,390 | 2.49 | 0.79 | -1.71 | sell |