| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 904,000 | 27,330,800 | +26,426,800 | 2.03 | 6.57 | +4.54 | buy |
| Eversept Partners, LP | 343,400 | 4,212,270 | +3,868,870 | 0.47 | 5.86 | +5.39 | buy |
| BANK OF AMERICA CORP /DE/ | 245,508 | 2,870,999 | +2,625,491 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,915,736 | 4,008,700 | +2,092,964 | 0.07 | 0.14 | +0.07 | buy |
| CITADEL ADVISORS LLC | 1,089,803 | 2,914,882 | +1,825,079 | 0.01 | 0.04 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 69,586 | 1,817,009 | +1,747,423 | 0.00 | 0.06 | +0.05 | buy |
| Catalio Capital Management, LP | 0 | 1,733,701 | +1,733,701 | 0.00 | 5.28 | +5.28 | buy |
| Sofinnova Investments, Inc. | 658,627 | 2,275,223 | +1,616,596 | 0.64 | 2.11 | +1.47 | buy |
| PFM Health Sciences, LP | 206,871 | 926,424 | +719,553 | 0.21 | 0.87 | +0.66 | buy |
| UBS Group AG | 1,028,821 | 1,715,778 | +686,957 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 184,117 | 787,587 | +603,470 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 267,949 | 689,064 | +421,115 | 0.01 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 65,213 | 377,444 | +312,231 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,766,859 | 2,061,405 | +294,546 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,381,241 | 1,663,974 | +282,733 | 3.37 | 5.04 | +1.67 | buy |
| Zimmer Partners, LP | 0 | 213,159 | +213,159 | 0.00 | 0.05 | +0.05 | buy |
| JPMORGAN CHASE & CO | 897,317 | 1,105,807 | +208,490 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 127,557 | 329,906 | +202,349 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 232,000 | 433,000 | +201,000 | 0.32 | 0.61 | +0.30 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 0 | 200,000 | +200,000 | 0.00 | 1.34 | +1.34 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,022,537 | 1,221,269 | +198,732 | 0.03 | 0.04 | +0.01 | buy |
| Point72 Europe (London) LLP | 0 | 184,683 | +184,683 | 0.00 | 0.16 | +0.16 | buy |
| ExodusPoint Capital Management, LP | 148,568 | 314,407 | +165,839 | 0.02 | 0.05 | +0.03 | buy |
| Casdin Capital, LLC | 475,000 | 635,000 | +160,000 | 0.42 | 0.64 | +0.22 | buy |
| DIMENSIONAL FUND ADVISORS LP | 331,300 | 465,882 | +134,582 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 89,904 | 204,732 | +114,828 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 724,416 | 834,849 | +110,433 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 669,823 | 780,009 | +110,186 | 0.02 | 0.02 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 200,000 | +100,000 | 0.09 | 0.14 | +0.05 | buy |
| ALGERT GLOBAL LLC | 785,632 | 884,600 | +98,968 | 0.24 | 0.27 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 92,216 | +92,216 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 29,022 | 117,613 | +88,591 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 85,250 | 168,684 | +83,434 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,230,400 | 1,309,224 | +78,824 | 3.64 | 3.36 | -0.28 | buy |
| Parkman Healthcare Partners LLC | 526,973 | 594,987 | +68,014 | 0.93 | 0.87 | -0.06 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 66,988 | +66,988 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 63,726 | +63,726 | 0.00 | 0.04 | +0.04 | buy |
| IEQ CAPITAL, LLC | 0 | 59,210 | +59,210 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 144,452 | 200,650 | +56,198 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,917,516 | 3,971,732 | +54,216 | 0.00 | 0.00 | -0.00 | buy |
| Saturn V Capital Management LP | 988,528 | 1,041,280 | +52,752 | 5.12 | 6.46 | +1.34 | buy |
| GSA CAPITAL PARTNERS LLP | 36,857 | 87,284 | +50,427 | 0.04 | 0.10 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,973,116 | 2,022,985 | +49,869 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 14,071 | 60,337 | +46,266 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 104,880 | 145,034 | +40,154 | 0.01 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 39,209 | +39,209 | 0.00 | 0.02 | +0.02 | buy |
| Palo Alto Investors LP | 405,193 | 444,367 | +39,174 | 0.83 | 1.04 | +0.21 | buy |
| FMR LLC | 85,201 | 122,258 | +37,057 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 37,475 | 74,352 | +36,877 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 35,037 | +35,037 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 99,340 | 132,433 | +33,093 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 170,100 | 200,696 | +30,596 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 14,475 | 41,526 | +27,051 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 26,838 | +26,838 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 20,657 | 46,395 | +25,738 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 51,324 | 76,848 | +25,524 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 24,158 | +24,158 | 0.00 | 0.05 | +0.05 | buy |
| Cerity Partners LLC | 0 | 24,048 | +24,048 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 32,518 | 55,664 | +23,146 | 0.00 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 84,998 | 106,628 | +21,630 | 0.02 | 0.04 | +0.03 | buy |
| NEOS Investment Management LLC | 0 | 21,169 | +21,169 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 21,169 | +21,169 | 0.00 | 0.08 | +0.08 | buy |
| CWM, LLC | 2,611 | 23,374 | +20,763 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 318,900 | 337,198 | +18,298 | 3.17 | 3.71 | +0.54 | buy |
| CIBC WORLD MARKETS CORP | 0 | 18,233 | +18,233 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 16,964 | +16,964 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 23,623 | 39,317 | +15,694 | 0.04 | 0.05 | +0.01 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 115,087 | 130,746 | +15,659 | 0.02 | 0.02 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 14,560 | +14,560 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 13,172 | +13,172 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 121,539 | 134,136 | +12,597 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 12,192 | +12,192 | 0.00 | 0.04 | +0.04 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 53,129 | 64,107 | +10,978 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 10,717 | +10,717 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 15,079 | 24,973 | +9,894 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 621,840 | 631,640 | +9,800 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,019 | 66,114 | +9,095 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 113,449 | 120,810 | +7,361 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 224,261 | 229,758 | +5,497 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 86,225 | 91,717 | +5,492 | 0.10 | 0.11 | +0.02 | buy |
| BARCLAYS PLC | 196,051 | 199,989 | +3,938 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 12,603 | 16,031 | +3,428 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,748 | 56,842 | +3,094 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 542,002 | 544,502 | +2,500 | 1.82 | 1.90 | +0.08 | buy |
| AMERIPRISE FINANCIAL INC | 31,982 | 34,228 | +2,246 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,657 | +1,657 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 34,548 | 35,481 | +933 | 0.02 | 0.02 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 42,117 | 42,960 | +843 | 0.00 | 0.00 | -0.00 | buy |
| Optimize Financial Inc | 11,509 | 12,227 | +718 | 0.11 | 0.06 | -0.06 | buy |
| GUGGENHEIM CAPITAL LLC | 11,881 | 12,490 | +609 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 9,201 | 9,769 | +568 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 680,965 | 681,427 | +462 | 0.01 | 0.01 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,792 | 2,186 | +394 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 271 | +271 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,911 | 2,144 | +233 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 63 | 248 | +185 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 167 | +167 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 147,641 | 147,785 | +144 | 0.14 | 0.08 | -0.05 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,029 | 10,148 | +119 | 0.00 | 0.00 | -0.00 | buy |