| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,239,002 | 8,254,426 | +15,424 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 8,050,959 | 8,050,959 | 0 | 11.01 | 11.94 | +0.92 | hold |
| GOLDMAN SACHS GROUP INC | 5,695,375 | 4,996,787 | -698,588 | 0.02 | 0.02 | -0.00 | sell |
| STATE STREET CORP | 4,596,552 | 4,430,076 | -166,476 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 4,710,746 | 4,249,836 | -460,910 | 0.01 | 0.01 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 3,779,900 | +3,779,900 | 0.00 | 1.04 | +1.04 | buy |
| Eversept Partners, LP | 3,314,408 | 2,885,622 | -428,786 | 3.90 | 4.44 | +0.54 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,350,000 | 2,500,000 | +150,000 | 7.56 | 9.78 | +2.22 | buy |
| Hood River Capital Management LLC | 2,316,553 | 2,354,285 | +37,732 | 0.53 | 0.55 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,090,932 | 2,157,058 | +66,126 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,421,666 | 2,150,079 | -271,587 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 4,882,053 | 1,985,547 | -2,896,506 | 0.16 | 0.08 | -0.08 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,375,681 | 1,732,541 | +356,860 | 0.03 | 0.05 | +0.01 | buy |
| Soleus Capital Management, L.P. | 2,247,110 | 1,726,908 | -520,202 | 2.00 | 1.63 | -0.37 | sell |
| D. E. Shaw & Co., Inc. | 1,219,609 | 1,601,896 | +382,287 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,146,936 | 1,579,596 | +432,660 | 0.04 | 0.03 | -0.01 | buy |
| Nuveen, LLC | 1,483,002 | 1,494,645 | +11,643 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 1,337,702 | 1,340,733 | +3,031 | 3.22 | 2.42 | -0.80 | buy |
| Aisling Capital Management LP | 1,316,806 | 1,316,806 | 0 | 5.78 | 6.46 | +0.68 | hold |
| Woodline Partners LP | 1,250,668 | 1,250,760 | +92 | 0.10 | 0.11 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 1,339,379 | 1,215,743 | -123,636 | 4.83 | 5.46 | +0.63 | sell |
| UBS Group AG | 716,219 | 1,153,662 | +437,443 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 1,196,807 | 1,043,670 | -153,137 | 4.44 | 5.09 | +0.65 | sell |
| Bank of New York Mellon Corp | 1,094,151 | 1,004,498 | -89,653 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 1,598,544 | 990,969 | -607,575 | 0.06 | 0.04 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 925,974 | 980,314 | +54,340 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 962,300 | +962,300 | 0.00 | 0.49 | +0.49 | buy |
| ALGERT GLOBAL LLC | 928,088 | 928,568 | +480 | 0.30 | 0.33 | +0.02 | buy |
| Candriam S.C.A. | 925,332 | 925,332 | 0 | 0.10 | 0.11 | +0.02 | hold |
| Parkman Healthcare Partners LLC | 574,023 | 901,511 | +327,488 | 1.15 | 2.18 | +1.04 | buy |
| MORGAN STANLEY | 1,075,501 | 893,933 | -181,568 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 642,899 | 888,987 | +246,088 | 1.95 | 2.45 | +0.49 | buy |
| Palo Alto Investors LP | 794,507 | 864,986 | +70,479 | 2.32 | 3.09 | +0.77 | buy |
| Prosight Management, LP | 665,000 | 770,000 | +105,000 | 2.89 | 2.95 | +0.06 | buy |
| NORTHERN TRUST CORP | 728,921 | 755,719 | +26,798 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 762,563 | 724,563 | -38,000 | 3.35 | 2.91 | -0.44 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 727,424 | 715,153 | -12,271 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 184,003 | 630,942 | +446,939 | 0.00 | 0.01 | +0.01 | buy |
| APIS CAPITAL ADVISORS, LLC | 724,000 | 550,000 | -174,000 | 2.65 | 1.98 | -0.67 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 544,800 | 498,200 | -46,600 | 0.02 | 0.02 | +0.00 | sell |
| Knott David M Jr | 415,000 | 422,000 | +7,000 | 4.04 | 5.87 | +1.83 | buy |
| Walleye Capital LLC | 24,205 | 384,973 | +360,768 | 0.00 | 0.06 | +0.05 | buy |
| Rhenman & Partners Asset Management AB | 487,000 | 379,250 | -107,750 | 0.96 | 1.09 | +0.14 | sell |
| Integral Health Asset Management, LLC | 200,000 | 350,000 | +150,000 | 0.21 | 0.43 | +0.22 | buy |
| JANE STREET GROUP, LLC | 748,920 | 335,531 | -413,389 | 0.02 | 0.01 | -0.01 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 137,629 | 331,665 | +194,036 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 366,793 | 306,321 | -60,472 | 0.33 | 0.35 | +0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 94,880 | 288,567 | +193,687 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 372,792 | 286,969 | -85,823 | 0.01 | 0.01 | -0.00 | sell |
| SECTOR GAMMA AS | 252,062 | 286,007 | +33,945 | 1.21 | 1.58 | +0.37 | buy |
| Pale Fire Capital SE | 284,460 | 284,460 | 0 | 0.77 | 0.58 | -0.19 | hold |
| AMERIPRISE FINANCIAL INC | 282,587 | 284,245 | +1,658 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 13,100 | 260,626 | +247,526 | 0.00 | 0.05 | +0.05 | buy |
| JPMORGAN CHASE & CO | 378,504 | 258,519 | -119,985 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 160,525 | 252,761 | +92,236 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 125,099 | 249,407 | +124,308 | 0.01 | 0.02 | +0.01 | buy |
| PFM Health Sciences, LP | 242,967 | 245,021 | +2,054 | 0.52 | 0.60 | +0.09 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 229,600 | 229,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 159,638 | 217,600 | +57,962 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 277,855 | 217,355 | -60,500 | 1.36 | 1.16 | -0.20 | sell |
| Hennion & Walsh Asset Management, Inc. | 183,802 | 214,807 | +31,005 | 0.13 | 0.17 | +0.04 | buy |
| Brevan Howard Capital Management LP | 515,129 | 204,845 | -310,284 | 0.21 | 0.05 | -0.16 | sell |
| Trexquant Investment LP | 87,514 | 201,777 | +114,263 | 0.02 | 0.03 | +0.02 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 200,000 | 200,000 | 0 | 2.05 | 1.78 | -0.27 | hold |
| MILLENNIUM MANAGEMENT LLC | 51,937 | 199,524 | +147,587 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 198,985 | +198,985 | 0.00 | 0.74 | +0.74 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,153 | 196,621 | +178,468 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 44,638 | 182,016 | +137,378 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 19,814 | 181,552 | +161,738 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 140,560 | 173,993 | +33,433 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 161,400 | 161,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atom Investors LP | 141,666 | 155,965 | +14,299 | 0.24 | 0.26 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 142,407 | 149,797 | +7,390 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 233,871 | 145,566 | -88,305 | 0.05 | 0.03 | -0.02 | sell |
| Rafferty Asset Management, LLC | 161,943 | 124,723 | -37,220 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 35,630 | 123,586 | +87,956 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 117,319 | +117,319 | 0.00 | 0.18 | +0.18 | buy |
| RHUMBLINE ADVISERS | 118,799 | 114,762 | -4,037 | 0.00 | 0.00 | +0.00 | sell |
| IEQ CAPITAL, LLC | 99,876 | 109,623 | +9,747 | 0.01 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 94,829 | 107,133 | +12,304 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 554,761 | 105,051 | -449,710 | 0.13 | 0.02 | -0.11 | sell |
| TORRAY INVESTMENT PARTNERS LLC | 97,802 | 104,868 | +7,066 | 0.29 | 0.36 | +0.07 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,199 | 103,009 | +24,810 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 89,639 | 101,492 | +11,853 | 0.00 | 0.00 | +0.00 | buy |
| Yelin Lapidot Holdings Management Ltd. | 108,377 | 96,297 | -12,080 | 0.46 | 0.47 | +0.01 | sell |
| TWINBEECH CAPITAL LP | 52,900 | 90,006 | +37,106 | 0.08 | 0.22 | +0.14 | buy |
| HRT FINANCIAL LP | 0 | 88,904 | +88,904 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 160,850 | 80,394 | -80,456 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 18,476 | 79,007 | +60,531 | 0.01 | 0.03 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 66,608 | 74,983 | +8,375 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 54,987 | 73,199 | +18,212 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 2,043 | 69,083 | +67,040 | 0.00 | 0.05 | +0.05 | buy |
| TUDOR INVESTMENT CORP ET AL | 47,421 | 69,059 | +21,638 | 0.01 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 39,127 | 66,340 | +27,213 | 0.02 | 0.05 | +0.02 | buy |
| Tidal Investments LLC | 0 | 65,326 | +65,326 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 165,000 | 62,330 | -102,670 | 0.02 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 78,236 | 59,058 | -19,178 | 0.00 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 100,053 | 58,348 | -41,705 | 0.16 | 0.09 | -0.07 | sell |
| PROFUND ADVISORS LLC | 60,038 | 55,904 | -4,134 | 0.04 | 0.05 | +0.01 | sell |
| MARSHALL WACE, LLP | 0 | 54,274 | +54,274 | 0.00 | 0.00 | +0.00 | buy |