| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 3,779,900 | +3,779,900 | 0.00 | 1.04 | +1.04 | buy |
| ORBIMED ADVISORS LLC | 0 | 962,300 | +962,300 | 0.00 | 0.49 | +0.49 | buy |
| CITADEL ADVISORS LLC | 184,003 | 630,942 | +446,939 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 716,219 | 1,153,662 | +437,443 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,146,936 | 1,579,596 | +432,660 | 0.04 | 0.03 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,219,609 | 1,601,896 | +382,287 | 0.02 | 0.03 | +0.01 | buy |
| Walleye Capital LLC | 24,205 | 384,973 | +360,768 | 0.00 | 0.06 | +0.05 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,375,681 | 1,732,541 | +356,860 | 0.03 | 0.05 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 574,023 | 901,511 | +327,488 | 1.15 | 2.18 | +1.04 | buy |
| Schonfeld Strategic Advisors LLC | 13,100 | 260,626 | +247,526 | 0.00 | 0.05 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 642,899 | 888,987 | +246,088 | 1.95 | 2.45 | +0.49 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 198,985 | +198,985 | 0.00 | 0.74 | +0.74 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 137,629 | 331,665 | +194,036 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 94,880 | 288,567 | +193,687 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,153 | 196,621 | +178,468 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 19,814 | 181,552 | +161,738 | 0.00 | 0.01 | +0.01 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,350,000 | 2,500,000 | +150,000 | 7.56 | 9.78 | +2.22 | buy |
| Integral Health Asset Management, LLC | 200,000 | 350,000 | +150,000 | 0.21 | 0.43 | +0.22 | buy |
| MILLENNIUM MANAGEMENT LLC | 51,937 | 199,524 | +147,587 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 44,638 | 182,016 | +137,378 | 0.00 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 125,099 | 249,407 | +124,308 | 0.01 | 0.02 | +0.01 | buy |
| Cinctive Capital Management LP | 0 | 117,319 | +117,319 | 0.00 | 0.18 | +0.18 | buy |
| Trexquant Investment LP | 87,514 | 201,777 | +114,263 | 0.02 | 0.03 | +0.02 | buy |
| Prosight Management, LP | 665,000 | 770,000 | +105,000 | 2.89 | 2.95 | +0.06 | buy |
| Invesco Ltd. | 160,525 | 252,761 | +92,236 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 88,904 | +88,904 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 35,630 | 123,586 | +87,956 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 794,507 | 864,986 | +70,479 | 2.32 | 3.09 | +0.77 | buy |
| Aquatic Capital Management LLC | 2,043 | 69,083 | +67,040 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,090,932 | 2,157,058 | +66,126 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 65,326 | +65,326 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 18,476 | 79,007 | +60,531 | 0.01 | 0.03 | +0.02 | buy |
| SEI INVESTMENTS CO | 159,638 | 217,600 | +57,962 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 925,974 | 980,314 | +54,340 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 54,274 | +54,274 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 53,149 | +53,149 | 0.00 | 0.33 | +0.33 | buy |
| Legato Capital Management LLC | 0 | 41,376 | +41,376 | 0.00 | 0.09 | +0.09 | buy |
| Hood River Capital Management LLC | 2,316,553 | 2,354,285 | +37,732 | 0.53 | 0.55 | +0.02 | buy |
| TWINBEECH CAPITAL LP | 52,900 | 90,006 | +37,106 | 0.08 | 0.22 | +0.14 | buy |
| Voleon Capital Management LP | 0 | 36,633 | +36,633 | 0.00 | 0.02 | +0.02 | buy |
| SECTOR GAMMA AS | 252,062 | 286,007 | +33,945 | 1.21 | 1.58 | +0.37 | buy |
| FMR LLC | 140,560 | 173,993 | +33,433 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 33,197 | +33,197 | 0.00 | 0.14 | +0.14 | buy |
| Hennion & Walsh Asset Management, Inc. | 183,802 | 214,807 | +31,005 | 0.13 | 0.17 | +0.04 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 9,707 | 38,331 | +28,624 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 27,968 | +27,968 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 39,127 | 66,340 | +27,213 | 0.02 | 0.05 | +0.02 | buy |
| NORTHERN TRUST CORP | 728,921 | 755,719 | +26,798 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 14,228 | 40,381 | +26,153 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 22,523 | 48,554 | +26,031 | 0.04 | 0.07 | +0.03 | buy |
| Headlands Technologies LLC | 0 | 25,392 | +25,392 | 0.00 | 0.07 | +0.07 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,199 | 103,009 | +24,810 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 47,421 | 69,059 | +21,638 | 0.01 | 0.01 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 18,340 | +18,340 | 0.00 | 0.06 | +0.06 | buy |
| Mariner, LLC | 54,987 | 73,199 | +18,212 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 18,940 | 37,031 | +18,091 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 24,806 | 41,872 | +17,066 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 8,239,002 | 8,254,426 | +15,424 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 15,242 | +15,242 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,461 | 39,904 | +14,443 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 141,666 | 155,965 | +14,299 | 0.24 | 0.26 | +0.02 | buy |
| Harbour Capital Advisors, LLC | 0 | 13,650 | +13,650 | 0.00 | 0.06 | +0.06 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 13,410 | +13,410 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,009 | +13,009 | 0.00 | 0.04 | +0.04 | buy |
| Bleakley Financial Group, LLC | 0 | 12,488 | +12,488 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 94,829 | 107,133 | +12,304 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,265 | 38,408 | +12,143 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 89,639 | 101,492 | +11,853 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 1,483,002 | 1,494,645 | +11,643 | 0.01 | 0.01 | +0.00 | buy |
| Bridgefront Capital, LLC | 19,752 | 31,101 | +11,349 | 0.10 | 0.18 | +0.08 | buy |
| Merit Financial Group, LLC | 0 | 10,954 | +10,954 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 10,791 | +10,791 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 28,856 | 39,083 | +10,227 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 9,775 | +9,775 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 99,876 | 109,623 | +9,747 | 0.01 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 4,844 | 14,432 | +9,588 | 0.00 | 0.01 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 9,563 | +9,563 | 0.00 | 0.00 | +0.00 | buy |
| WEDBUSH SECURITIES INC | 0 | 9,054 | +9,054 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 66,608 | 74,983 | +8,375 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 33,549 | 41,445 | +7,896 | 0.19 | 0.27 | +0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 142,407 | 149,797 | +7,390 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 24,711 | 31,902 | +7,191 | 0.00 | 0.00 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 97,802 | 104,868 | +7,066 | 0.29 | 0.36 | +0.07 | buy |
| Knott David M Jr | 415,000 | 422,000 | +7,000 | 4.04 | 5.87 | +1.83 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 17,805 | 23,637 | +5,832 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 12,000 | 17,500 | +5,500 | 0.02 | 0.02 | +0.01 | buy |
| CWM, LLC | 31,912 | 37,046 | +5,134 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,761 | 45,846 | +5,085 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 15,060 | 20,060 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,541 | 24,739 | +4,198 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,337,702 | 1,340,733 | +3,031 | 3.22 | 2.42 | -0.80 | buy |
| Rockefeller Capital Management L.P. | 472 | 3,209 | +2,737 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 11,127 | 13,841 | +2,714 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 11,109 | 13,660 | +2,551 | 0.00 | 0.01 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 20,195 | 22,545 | +2,350 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 20,339 | 22,576 | +2,237 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 242,967 | 245,021 | +2,054 | 0.52 | 0.60 | +0.09 | buy |
| Allspring Global Investments Holdings, LLC | 17,562 | 19,564 | +2,002 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 282,587 | 284,245 | +1,658 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 14,033 | 15,678 | +1,645 | 0.01 | 0.01 | +0.00 | buy |