| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avidity Partners Management LP | 2,412,500 | 3,335,000 | +922,500 | 2.04 | 2.91 | +0.87 | buy |
| Sofinnova Investments, Inc. | 1,608,540 | 2,153,669 | +545,129 | 2.13 | 2.30 | +0.17 | buy |
| Commodore Capital LP | 318,851 | 825,000 | +506,149 | 0.51 | 1.16 | +0.65 | buy |
| Eversept Partners, LP | 3,133,113 | 3,613,631 | +480,518 | 4.97 | 5.08 | +0.11 | buy |
| Soleus Capital Management, L.P. | 369,000 | 826,500 | +457,500 | 0.77 | 1.50 | +0.73 | buy |
| ExodusPoint Capital Management, LP | 286,330 | 625,723 | +339,393 | 0.09 | 0.14 | 0.00 | buy |
| STEMPOINT CAPITAL LP | 1,100,988 | 1,412,176 | +311,188 | 7.00 | 8.53 | +1.53 | buy |
| TWO SIGMA INVESTMENTS, LP | 718,552 | 930,947 | +212,395 | 0.04 | 0.05 | 0.00 | buy |
| Granahan Investment Management, LLC | 396,878 | 594,386 | +197,508 | 0.33 | 0.49 | +0.16 | buy |
| ORBIMED ADVISORS LLC | 1,749,000 | 1,925,300 | +176,300 | 0.76 | 0.79 | +0.02 | buy |
| TWINBEECH CAPITAL LP | 71,883 | 167,714 | +95,831 | 0.04 | 0.07 | +0.03 | buy |
| Kynam Capital Management, LP | 5,660,000 | 5,722,057 | +62,057 | 14.99 | 12.30 | -2.69 | buy |
| Rhenman & Partners Asset Management AB | 178,500 | 228,500 | +50,000 | 0.40 | 0.45 | +0.05 | buy |
| Crestline Management, LP | 103,710 | 143,280 | +39,570 | 0.22 | 0.23 | +0.01 | buy |
| Knott David M Jr | 65,475 | 103,826 | +38,351 | 0.55 | 0.85 | +0.30 | buy |
| PROFUND ADVISORS LLC | 58,247 | 33,231 | +25,016 | 0.05 | 0.03 | 0.00 | sell |
| Saturn V Capital Management LP | 397,997 | 419,654 | +21,657 | 3.80 | 3.26 | -0.54 | buy |
| BIT Capital GmbH | 66,964 | 79,786 | +12,822 | 0.12 | 0.13 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 812,964 | 822,047 | +9,083 | 2.72 | 2.30 | -0.42 | buy |
| AlphaQuest LLC | 5,707 | 13,635 | +7,928 | 0.02 | 0.04 | 0.00 | buy |
| ALGERT GLOBAL LLC | 425,673 | 432,128 | +6,455 | 0.40 | 0.31 | 0.00 | buy |
| ALPS ADVISORS INC | 59,924 | 66,293 | +6,369 | 0.01 | 0.01 | -0.00 | buy |
| DnB Asset Management AS | 9,368 | 13,172 | +3,804 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 3,500 | 6,125 | +2,625 | 0.03 | 0.05 | 0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 196,079 | 198,659 | +2,580 | 0.13 | 0.12 | -0.01 | buy |
| Inspire Investing, LLC | 15,032 | 17,290 | +2,258 | 0.04 | 0.04 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 108,431 | 110,454 | +2,023 | 0.19 | 0.14 | 0.00 | buy |
| Woodline Partners LP | 1,544,287 | 1,545,528 | +1,241 | 0.34 | 0.30 | -0.04 | buy |
| JENNISON ASSOCIATES LLC | 50,170 | 51,334 | +1,164 | 0.00 | 0.00 | -0.00 | buy |
| AXIOM INVESTORS LLC /DE | 94,065 | 95,140 | +1,075 | 0.02 | 0.02 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 186 | 213 | +27 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,359 | 4,373 | +14 | 0.06 | 0.04 | -0.01 | buy |
| Simplify Asset Management Inc. | 75,337 | 75,193 | -144 | 0.17 | 0.14 | -0.04 | sell |
| NVWM, LLC | 42,962 | 42,700 | -262 | 0.28 | 0.23 | -0.05 | sell |
| DAFNA Capital Management LLC | 659,574 | 657,074 | -2,500 | 3.57 | 3.22 | -0.35 | sell |
| China Universal Asset Management Co., Ltd. | 16,338 | 9,984 | -6,354 | 0.05 | 0.03 | -0.02 | sell |
| E Fund Management Co., Ltd. | 17,638 | 10,806 | -6,832 | 0.03 | 0.01 | -0.01 | sell |
| EntryPoint Capital, LLC | 8,636 | 1,090 | -7,546 | 0.18 | 0.03 | -0.15 | sell |
| Nantahala Capital Management, LLC | 465,259 | 453,232 | -12,027 | 0.63 | 0.54 | -0.09 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,000 | 860,000 | -40,000 | 0.04 | 0.03 | -0.01 | sell |
| Candriam S.C.A. | 1,045,032 | 970,106 | -74,926 | 0.16 | 0.12 | -0.04 | sell |
| Parkman Healthcare Partners LLC | 784,811 | 600,698 | -184,113 | 2.29 | 1.68 | -0.61 | sell |
| Rafferty Asset Management, LLC | 373,238 | 177,920 | -195,318 | 0.03 | 0.01 | -0.02 | sell |
| PFM Health Sciences, LP | 658,694 | 387,357 | -271,337 | 0.74 | 0.39 | -0.34 | sell |
| Avoro Capital Advisors LLC | 4,222,222 | 3,888,437 | -333,785 | 1.17 | 1.06 | -0.11 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 780,000 | 228,625 | -551,375 | 0.06 | 0.01 | -0.05 | sell |
| T. Rowe Price Investment Management, Inc. | 2,459,235 | 283,827 | -2,175,408 | 0.04 | 0.00 | -0.03 | sell |