| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avidity Partners Management LP | 2,412,500 | 3,335,000 | +922,500 | 2.04 | 2.91 | +0.87 | buy |
| Point72 Asset Management, L.P. | 2,066,685 | 2,782,853 | +716,168 | 0.14 | 0.18 | +0.04 | buy |
| First Turn Management, LLC | 0 | 640,389 | +640,389 | 0.00 | 2.14 | +2.14 | buy |
| Prosight Management, LP | 0 | 551,544 | +551,544 | 0.00 | 3.38 | +3.38 | buy |
| Sofinnova Investments, Inc. | 1,608,540 | 2,153,669 | +545,129 | 2.26 | 2.79 | +0.53 | buy |
| Commodore Capital LP | 318,851 | 825,000 | +506,149 | 0.51 | 1.16 | +0.65 | buy |
| Eversept Partners, LP | 3,133,113 | 3,613,631 | +480,518 | 5.57 | 5.68 | +0.10 | buy |
| Soleus Capital Management, L.P. | 369,000 | 826,500 | +457,500 | 0.77 | 1.50 | +0.73 | buy |
| MILLENNIUM MANAGEMENT LLC | 681,874 | 1,065,508 | +383,634 | 0.01 | 0.02 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 370,000 | +370,000 | 0.00 | 1.88 | +1.88 | buy |
| ExodusPoint Capital Management, LP | 286,330 | 625,723 | +339,393 | 0.08 | 0.14 | +0.06 | buy |
| STEMPOINT CAPITAL LP | 1,100,988 | 1,412,176 | +311,188 | 7.00 | 8.53 | +1.53 | buy |
| TWO SIGMA INVESTMENTS, LP | 718,552 | 930,947 | +212,395 | 0.04 | 0.05 | +0.00 | buy |
| Qube Research & Technologies Ltd | 93,889 | 297,303 | +203,414 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 396,878 | 594,386 | +197,508 | 0.33 | 0.49 | +0.16 | buy |
| ORBIMED ADVISORS LLC | 1,749,000 | 1,925,300 | +176,300 | 0.76 | 0.79 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 455,852 | 621,252 | +165,400 | 0.03 | 0.03 | +0.00 | buy |
| CITADEL ADVISORS LLC | 33,809 | 189,981 | +156,172 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 277,928 | 428,949 | +151,021 | 0.02 | 0.02 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 8,524 | 146,643 | +138,119 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 79,100 | 214,300 | +135,200 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,310,073 | 1,444,012 | +133,939 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,778,548 | 1,910,623 | +132,075 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,760 | 134,430 | +118,670 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 538,714 | 656,250 | +117,536 | 0.03 | 0.03 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 71,883 | 167,714 | +95,831 | 0.04 | 0.07 | +0.03 | buy |
| Nicholas Investment Partners, LP | 0 | 62,366 | +62,366 | 0.00 | 0.13 | +0.13 | buy |
| Kynam Capital Management, LP | 5,660,000 | 5,722,057 | +62,057 | 14.99 | 12.30 | -2.69 | buy |
| FRANKLIN RESOURCES INC | 1,495,705 | 1,555,234 | +59,529 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 96,833 | 153,360 | +56,527 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 55,835 | +55,835 | 0.00 | 0.22 | +0.22 | buy |
| Rhenman & Partners Asset Management AB | 178,500 | 228,500 | +50,000 | 0.40 | 0.45 | +0.05 | buy |
| Artia Global Partners LP | 0 | 48,263 | +48,263 | 0.00 | 0.25 | +0.25 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 47,153 | +47,153 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 245,363 | 291,826 | +46,463 | 0.00 | 0.00 | +0.00 | buy |
| Clearline Capital LP | 0 | 42,195 | +42,195 | 0.00 | 0.08 | +0.08 | buy |
| JANE STREET GROUP, LLC | 113,528 | 153,311 | +39,783 | 0.00 | 0.00 | -0.00 | buy |
| Crestline Management, LP | 103,710 | 143,280 | +39,570 | 0.23 | 0.23 | -0.00 | buy |
| Knott David M Jr | 65,475 | 103,826 | +38,351 | 0.55 | 0.85 | +0.30 | buy |
| Jump Financial, LLC | 0 | 37,500 | +37,500 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 42,487 | 75,840 | +33,353 | 0.03 | 0.04 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 33,123 | +33,123 | 0.00 | 0.06 | +0.06 | buy |
| SG Americas Securities, LLC | 0 | 31,051 | +31,051 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 397,997 | 419,654 | +21,657 | 3.80 | 3.26 | -0.54 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 19,386 | +19,386 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 74,592 | 93,906 | +19,314 | 0.04 | 0.03 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 635,207 | 654,489 | +19,282 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 657 | 15,655 | +14,998 | 0.00 | 0.01 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 7,182 | 20,662 | +13,480 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 13,286 | +13,286 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 66,964 | 79,786 | +12,822 | 0.14 | 0.15 | +0.01 | buy |
| ProShare Advisors LLC | 20,112 | 31,600 | +11,488 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 11,404 | +11,404 | 0.00 | 0.05 | +0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 41,201 | 52,287 | +11,086 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 10,737 | +10,737 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 108,994 | 119,285 | +10,291 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 9,803 | +9,803 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 511,501 | 521,080 | +9,579 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 812,964 | 822,047 | +9,083 | 3.13 | 2.75 | -0.38 | buy |
| ROYAL BANK OF CANADA | 0 | 8,215 | +8,215 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 5,707 | 13,635 | +7,928 | 0.02 | 0.04 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 77,460 | 85,250 | +7,790 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 40,324 | 47,554 | +7,230 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,913 | 48,668 | +6,755 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 425,673 | 432,128 | +6,455 | 0.40 | 0.30 | -0.10 | buy |
| ALPS ADVISORS INC | 59,924 | 66,293 | +6,369 | 0.01 | 0.01 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 13,218 | 18,968 | +5,750 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 40,463 | 45,928 | +5,465 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 69,778 | 74,425 | +4,647 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 514,852 | 518,885 | +4,033 | 0.02 | 0.02 | -0.00 | buy |
| HSBC HOLDINGS PLC | 39,591 | 43,597 | +4,006 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 14,466 | 18,428 | +3,962 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 9,368 | 13,172 | +3,804 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 44,510 | 48,198 | +3,688 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 0 | 3,395 | +3,395 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 25,300 | 28,200 | +2,900 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 10,412 | 13,283 | +2,871 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 34,070 | 36,871 | +2,801 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 2,800 | +2,800 | 0.00 | 0.02 | +0.02 | buy |
| Quarry LP | 3,500 | 6,125 | +2,625 | 0.03 | 0.05 | +0.02 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 196,079 | 198,659 | +2,580 | 0.13 | 0.12 | -0.01 | buy |
| Inspire Investing, LLC | 15,032 | 17,290 | +2,258 | 0.04 | 0.04 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 108,431 | 110,454 | +2,023 | 0.07 | 0.06 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 29,173 | 31,169 | +1,996 | 0.00 | 0.00 | -0.00 | buy |
| nVerses Capital, LLC | 0 | 1,600 | +1,600 | 0.00 | 0.02 | +0.02 | buy |
| GROUP ONE TRADING LLC | 763 | 2,318 | +1,555 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 1,300 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,544,287 | 1,545,528 | +1,241 | 0.34 | 0.30 | -0.04 | buy |
| Invesco Ltd. | 48,835 | 50,061 | +1,226 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 50,170 | 51,334 | +1,164 | 0.00 | 0.00 | -0.00 | buy |
| AXIOM INVESTORS LLC /DE | 94,065 | 95,140 | +1,075 | 0.02 | 0.02 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 104 | 1,012 | +908 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 2,692 | 3,544 | +852 | 0.00 | 0.00 | +0.00 | buy |
| MATHER GROUP, LLC. | 0 | 750 | +750 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 963 | 1,509 | +546 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 20,977 | 21,407 | +430 | 0.00 | 0.00 | -0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 25 | 253 | +228 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,660 | 2,766 | +106 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 60 | 130 | +70 | 0.00 | 0.00 | +0.00 | buy |