| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 631,640 | 1,432,440 | +800,800 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 1,598,594 | 2,372,634 | +774,040 | 6.27 | 7.15 | +0.88 | buy |
| Prosight Management, LP | 609,252 | 1,079,673 | +470,421 | 2.46 | 2.47 | +0.01 | buy |
| Granahan Investment Management, LLC | 549,942 | 991,388 | +441,446 | 0.34 | 0.38 | +0.04 | buy |
| Zimmer Partners, LP | 213,159 | 605,800 | +392,641 | 0.05 | 0.12 | +0.07 | buy |
| Catalio Capital Management, LP | 1,733,701 | 2,104,512 | +370,811 | 5.28 | 4.13 | -1.15 | buy |
| Aisling Capital Management LP | 1,025,000 | 1,316,806 | +291,806 | 4.36 | 3.43 | -0.94 | buy |
| Soleus Capital Management, L.P. | 816,610 | 1,092,110 | +275,500 | 0.79 | 0.71 | -0.08 | buy |
| Parkman Healthcare Partners LLC | 594,987 | 867,813 | +272,826 | 0.87 | 0.94 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,178,062 | 1,414,081 | +236,019 | 0.29 | 0.23 | -0.06 | buy |
| Knott David M Jr | 128,000 | 352,778 | +224,778 | 0.74 | 1.50 | +0.76 | buy |
| Candriam S.C.A. | 450,435 | 675,085 | +224,650 | 0.03 | 0.04 | +0.00 | buy |
| Nantahala Capital Management, LLC | 554,503 | 754,503 | +200,000 | 0.27 | 0.28 | +0.01 | buy |
| Aberdeen Group plc | 132,433 | 303,426 | +170,993 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 433,000 | 574,000 | +141,000 | 0.61 | 0.68 | +0.07 | buy |
| ALGERT GLOBAL LLC | 884,600 | 1,021,280 | +136,680 | 0.27 | 0.20 | 0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,000,000 | 2,100,000 | +100,000 | 5.09 | 3.80 | -1.29 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 250,000 | 155,000 | +95,000 | 0.01 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 21,169 | 86,301 | +65,132 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 21,169 | 86,301 | +65,132 | 0.08 | 0.21 | +0.14 | buy |
| SummitTX Capital, L.P. | 164,233 | 211,244 | +47,011 | 0.09 | 0.09 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 59,438 | 90,441 | +31,003 | 0.06 | 0.04 | 0.00 | buy |
| Inspire Investing, LLC | 27,898 | 42,923 | +15,025 | 0.04 | 0.04 | +0.00 | buy |
| Casdin Capital, LLC | 635,000 | 650,000 | +15,000 | 0.64 | 0.55 | -0.08 | buy |
| DnB Asset Management AS | 22,378 | 29,362 | +6,984 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,891,803 | 1,892,751 | +948 | 0.15 | 0.09 | -0.06 | buy |
| China Universal Asset Management Co., Ltd. | 17,121 | 17,282 | +161 | 0.02 | 0.02 | -0.00 | buy |
| Optimize Financial Inc | 12,227 | 12,141 | -86 | 0.11 | 0.07 | -0.04 | sell |
| DAFNA Capital Management LLC | 544,502 | 543,602 | -900 | 1.90 | 1.41 | -0.49 | sell |
| Freestone Grove Partners LP | 16,964 | 15,457 | -1,507 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 91,717 | 89,833 | -1,884 | 0.09 | 0.08 | -0.00 | sell |
| E Fund Management Co., Ltd. | 16,031 | 14,033 | -1,998 | 0.01 | 0.01 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 12,192 | 8,813 | -3,379 | 0.04 | 0.03 | -0.01 | sell |
| PROFUND ADVISORS LLC | 35,481 | 26,639 | -8,842 | 0.02 | 0.01 | -0.01 | sell |
| Polar Asset Management Partners Inc. | 106,628 | 97,113 | -9,515 | 0.03 | 0.01 | -0.02 | sell |
| Exome Asset Management LLC | 337,198 | 308,298 | -28,900 | 3.71 | 2.38 | -1.33 | sell |
| Atom Investors LP | 57,274 | 13,104 | -44,170 | 0.09 | 0.01 | -0.08 | sell |
| Nebula Research & Development LLC | 72,558 | 27,231 | -45,327 | 0.08 | 0.02 | -0.06 | sell |
| Rafferty Asset Management, LLC | 171,541 | 126,045 | -45,496 | 0.01 | 0.00 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,663,974 | 1,571,564 | -92,410 | 4.71 | 3.45 | -1.25 | sell |
| Simplify Asset Management Inc. | 147,785 | 25,049 | -122,736 | 0.08 | 0.01 | -0.07 | sell |
| TWINBEECH CAPITAL LP | 255,832 | 112,794 | -143,038 | 0.06 | 0.02 | -0.03 | sell |
| Eversept Partners, LP | 4,212,270 | 4,065,355 | -146,915 | 5.26 | 3.50 | -1.75 | sell |
| Saturn V Capital Management LP | 1,041,280 | 500,551 | -540,729 | 6.46 | 1.90 | -4.56 | sell |
| Sofinnova Investments, Inc. | 2,275,223 | 1,524,440 | -750,783 | 1.83 | 0.87 | -0.95 | sell |
| Avidity Partners Management LP | 925,000 | 150,000 | -775,000 | 2.34 | 0.28 | -2.06 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,309,224 | 402,964 | -906,260 | 3.36 | 0.77 | -2.59 | sell |