| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,542,251 | 10,456,907 | +1,914,656 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 3,921,541 | 5,797,195 | +1,875,654 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 428,652 | 1,598,613 | +1,169,961 | 0.01 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 2,870,999 | 3,838,872 | +967,873 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 834,849 | 1,665,916 | +831,067 | 0.02 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 631,640 | 1,432,440 | +800,800 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 1,598,594 | 2,372,634 | +774,040 | 6.27 | 7.15 | +0.88 | buy |
| Prosight Management, LP | 609,252 | 1,079,673 | +470,421 | 2.46 | 2.47 | +0.01 | buy |
| Granahan Investment Management, LLC | 549,942 | 991,388 | +441,446 | 0.34 | 0.38 | +0.04 | buy |
| Zimmer Partners, LP | 213,159 | 605,800 | +392,641 | 0.05 | 0.13 | +0.08 | buy |
| Jump Financial, LLC | 0 | 381,035 | +381,035 | 0.00 | 0.05 | +0.05 | buy |
| Catalio Capital Management, LP | 1,733,701 | 2,104,512 | +370,811 | 5.28 | 4.13 | -1.15 | buy |
| ROYAL BANK OF CANADA | 0 | 351,263 | +351,263 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 181,900 | 504,471 | +322,571 | 0.10 | 0.43 | +0.33 | buy |
| FRANKLIN RESOURCES INC | 2,061,405 | 2,359,677 | +298,272 | 0.01 | 0.01 | -0.00 | buy |
| Aisling Capital Management LP | 1,025,000 | 1,316,806 | +291,806 | 4.36 | 3.43 | -0.94 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 216,993 | 499,903 | +282,910 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 276,932 | +276,932 | 0.00 | 0.06 | +0.06 | buy |
| Soleus Capital Management, L.P. | 816,610 | 1,092,110 | +275,500 | 0.79 | 0.71 | -0.08 | buy |
| Parkman Healthcare Partners LLC | 594,987 | 867,813 | +272,826 | 0.87 | 0.94 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,178,062 | 1,414,081 | +236,019 | 0.29 | 0.23 | -0.06 | buy |
| MARSHALL WACE, LLP | 0 | 232,123 | +232,123 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 128,000 | 352,778 | +224,778 | 0.74 | 1.50 | +0.76 | buy |
| Candriam S.C.A. | 450,435 | 675,085 | +224,650 | 0.03 | 0.04 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,221,269 | 1,445,440 | +224,171 | 0.04 | 0.03 | -0.01 | buy |
| Schonfeld Strategic Advisors LLC | 46,395 | 264,744 | +218,349 | 0.00 | 0.02 | +0.01 | buy |
| Nantahala Capital Management, LLC | 554,503 | 754,503 | +200,000 | 0.56 | 0.50 | -0.06 | buy |
| Hudson Bay Capital Management LP | 250,000 | 443,300 | +193,300 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 199,989 | 382,966 | +182,977 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 178,289 | +178,289 | 0.00 | 0.02 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 400 | 176,030 | +175,630 | 0.00 | 0.02 | +0.02 | buy |
| Aberdeen Group plc | 132,433 | 303,426 | +170,993 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,871,065 | 5,033,934 | +162,869 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 681,427 | 837,700 | +156,273 | 0.01 | 0.01 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 433,000 | 574,000 | +141,000 | 0.61 | 0.68 | +0.07 | buy |
| ALGERT GLOBAL LLC | 884,600 | 1,021,280 | +136,680 | 0.27 | 0.20 | -0.07 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 128,845 | +128,845 | 0.00 | 0.04 | +0.04 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 39,209 | 160,327 | +121,118 | 0.02 | 0.06 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 42,960 | 154,406 | +111,446 | 0.00 | 0.00 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,000,000 | 2,100,000 | +100,000 | 5.09 | 3.80 | -1.29 | buy |
| Man Group plc | 134,136 | 228,167 | +94,031 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 92,900 | +92,900 | 0.00 | 0.86 | +0.86 | buy |
| Verition Fund Management LLC | 35,037 | 125,345 | +90,308 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,107 | 141,113 | +77,006 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 92,216 | 167,493 | +75,277 | 0.00 | 0.00 | +0.00 | buy |
| Phoenix Financial Ltd. | 0 | 74,963 | +74,963 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 21,169 | 86,301 | +65,132 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 21,169 | 86,301 | +65,132 | 0.08 | 0.21 | +0.14 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 57,565 | 122,163 | +64,598 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 63,300 | +63,300 | 0.00 | 0.39 | +0.39 | buy |
| AMERIPRISE FINANCIAL INC | 34,228 | 96,674 | +62,446 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 2,000 | 59,000 | +57,000 | 0.01 | 0.13 | +0.12 | buy |
| HSBC HOLDINGS PLC | 50,275 | 106,787 | +56,512 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 200,696 | 256,138 | +55,442 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 126,485 | 179,276 | +52,791 | 0.03 | 0.02 | -0.01 | buy |
| SummitTX Capital, L.P. | 164,233 | 211,244 | +47,011 | 0.09 | 0.09 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 46,829 | +46,829 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 46,189 | 90,855 | +44,666 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 224,153 | 266,043 | +41,890 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 329,906 | 371,463 | +41,557 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 122,258 | 160,918 | +38,660 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 37,257 | +37,257 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 32,185 | +32,185 | 0.00 | 0.01 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 59,438 | 90,441 | +31,003 | 0.02 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 76,848 | 105,157 | +28,309 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,022,985 | 2,049,350 | +26,365 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 23,530 | +23,530 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 689,693 | 712,310 | +22,617 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 465,882 | 487,647 | +21,765 | 0.00 | 0.00 | -0.00 | buy |
| Bryce Point Capital, LLC | 0 | 21,109 | +21,109 | 0.00 | 0.17 | +0.17 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 18,363 | +18,363 | 0.00 | 0.03 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 1,657 | 19,921 | +18,264 | 0.00 | 0.01 | +0.00 | buy |
| Corton Capital Inc. | 0 | 17,856 | +17,856 | 0.00 | 0.19 | +0.19 | buy |
| Inspire Investing, LLC | 27,898 | 42,923 | +15,025 | 0.04 | 0.04 | +0.00 | buy |
| Casdin Capital, LLC | 635,000 | 650,000 | +15,000 | 0.64 | 0.55 | -0.08 | buy |
| Swiss National Bank | 149,400 | 164,300 | +14,900 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 74,352 | 89,102 | +14,750 | 0.00 | 0.00 | -0.00 | buy |
| DRW Securities, LLC | 0 | 14,135 | +14,135 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 0 | 12,356 | +12,356 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 12,093 | +12,093 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 10,969 | +10,969 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 10,350 | +10,350 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 66,114 | 75,404 | +9,290 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 117,613 | 126,158 | +8,545 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 120,810 | 128,732 | +7,922 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 229,758 | 237,101 | +7,343 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,260 | 20,541 | +7,281 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 7,142 | +7,142 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 22,378 | 29,362 | +6,984 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 4,327 | +4,327 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,172 | 8,480 | +4,308 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 80,638 | 84,575 | +3,937 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 22,007 | 25,087 | +3,080 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,670 | 44,149 | +2,479 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 20,674 | 23,132 | +2,458 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 0 | 1,940 | +1,940 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 209 | 1,277 | +1,068 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 1,891,803 | 1,892,751 | +948 | 0.15 | 0.09 | -0.06 | buy |