| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,542,251 | 10,456,907 | +1,914,656 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 8,520,000 | 8,520,000 | 0 | 8.96 | 8.59 | -0.37 | hold |
| GOLDMAN SACHS GROUP INC | 3,921,541 | 5,797,195 | +1,875,654 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 4,871,065 | 5,033,934 | +162,869 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 4,212,270 | 4,065,355 | -146,915 | 5.86 | 3.84 | -2.02 | sell |
| BANK OF AMERICA CORP /DE/ | 2,870,999 | 3,838,872 | +967,873 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 3,971,732 | 3,442,752 | -528,980 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 1,598,594 | 2,372,634 | +774,040 | 6.27 | 7.15 | +0.88 | buy |
| FRANKLIN RESOURCES INC | 2,061,405 | 2,359,677 | +298,272 | 0.01 | 0.01 | -0.00 | buy |
| Point72 Asset Management, L.P. | 4,008,700 | 2,127,467 | -1,881,233 | 0.14 | 0.05 | -0.09 | sell |
| Catalio Capital Management, LP | 1,733,701 | 2,104,512 | +370,811 | 5.28 | 4.13 | -1.15 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,000,000 | 2,100,000 | +100,000 | 5.09 | 3.80 | -1.29 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,022,985 | 2,049,350 | +26,365 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 2,039,987 | 2,039,987 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Woodline Partners LP | 1,891,803 | 1,892,751 | +948 | 0.15 | 0.09 | -0.06 | buy |
| Qube Research & Technologies Ltd | 834,849 | 1,665,916 | +831,067 | 0.02 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 428,652 | 1,598,613 | +1,169,961 | 0.01 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,663,974 | 1,571,564 | -92,410 | 5.04 | 3.85 | -1.19 | sell |
| Sofinnova Investments, Inc. | 2,275,223 | 1,524,440 | -750,783 | 2.11 | 0.97 | -1.14 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,221,269 | 1,445,440 | +224,171 | 0.04 | 0.03 | -0.01 | buy |
| UBS Group AG | 1,715,778 | 1,435,415 | -280,363 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 631,640 | 1,432,440 | +800,800 | 0.01 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,178,062 | 1,414,081 | +236,019 | 0.29 | 0.23 | -0.06 | buy |
| Aisling Capital Management LP | 1,025,000 | 1,316,806 | +291,806 | 4.36 | 3.43 | -0.94 | buy |
| Soleus Capital Management, L.P. | 816,610 | 1,092,110 | +275,500 | 0.79 | 0.71 | -0.08 | buy |
| Prosight Management, LP | 609,252 | 1,079,673 | +470,421 | 2.46 | 2.47 | +0.01 | buy |
| ALGERT GLOBAL LLC | 884,600 | 1,021,280 | +136,680 | 0.27 | 0.20 | -0.07 | buy |
| Granahan Investment Management, LLC | 549,942 | 991,388 | +441,446 | 0.34 | 0.38 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 594,987 | 867,813 | +272,826 | 0.87 | 0.94 | +0.07 | buy |
| MORGAN STANLEY | 2,281,916 | 849,236 | -1,432,680 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 681,427 | 837,700 | +156,273 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 778,758 | 770,451 | -8,307 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 554,503 | 754,503 | +200,000 | 0.56 | 0.50 | -0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 689,693 | 712,310 | +22,617 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 689,064 | 689,064 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Candriam S.C.A. | 450,435 | 675,085 | +224,650 | 0.03 | 0.04 | +0.00 | buy |
| Casdin Capital, LLC | 635,000 | 650,000 | +15,000 | 0.64 | 0.55 | -0.08 | buy |
| D. E. Shaw & Co., Inc. | 787,587 | 644,542 | -143,045 | 0.01 | 0.01 | -0.01 | sell |
| CITADEL ADVISORS LLC | 2,914,882 | 640,000 | -2,274,882 | 0.04 | 0.01 | -0.03 | sell |
| Zimmer Partners, LP | 213,159 | 605,800 | +392,641 | 0.05 | 0.13 | +0.08 | buy |
| Rhenman & Partners Asset Management AB | 433,000 | 574,000 | +141,000 | 0.61 | 0.68 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 780,009 | 556,971 | -223,038 | 0.02 | 0.01 | -0.01 | sell |
| DAFNA Capital Management LLC | 544,502 | 543,602 | -900 | 1.90 | 1.41 | -0.49 | sell |
| Caption Management, LLC | 181,900 | 504,471 | +322,571 | 0.10 | 0.43 | +0.33 | buy |
| Saturn V Capital Management LP | 1,041,280 | 500,551 | -540,729 | 6.46 | 1.90 | -4.56 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 216,993 | 499,903 | +282,910 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 465,882 | 487,647 | +21,765 | 0.00 | 0.00 | -0.00 | buy |
| Palo Alto Investors LP | 444,367 | 444,367 | 0 | 1.04 | 0.89 | -0.15 | hold |
| Hudson Bay Capital Management LP | 250,000 | 443,300 | +193,300 | 0.02 | 0.03 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,309,224 | 402,964 | -906,260 | 3.36 | 0.77 | -2.59 | sell |
| TWO SIGMA ADVISERS, LP | 503,152 | 392,452 | -110,700 | 0.01 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 199,989 | 382,966 | +182,977 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 381,035 | +381,035 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 329,906 | 371,463 | +41,557 | 0.01 | 0.01 | -0.00 | buy |
| Knott David M Jr | 128,000 | 352,778 | +224,778 | 0.74 | 1.50 | +0.76 | buy |
| ROYAL BANK OF CANADA | 0 | 351,263 | +351,263 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 337,198 | 308,298 | -28,900 | 3.71 | 2.38 | -1.33 | sell |
| Aberdeen Group plc | 132,433 | 303,426 | +170,993 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 276,932 | +276,932 | 0.00 | 0.06 | +0.06 | buy |
| JPMORGAN CHASE & CO | 1,105,807 | 272,874 | -832,933 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 224,153 | 266,043 | +41,890 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 46,395 | 264,744 | +218,349 | 0.00 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 200,696 | 256,138 | +55,442 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 229,758 | 237,101 | +7,343 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 232,123 | +232,123 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 377,444 | 230,577 | -146,867 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 134,136 | 228,167 | +94,031 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 327,134 | 226,015 | -101,119 | 0.04 | 0.02 | -0.02 | sell |
| SummitTX Capital, L.P. | 164,233 | 211,244 | +47,011 | 0.09 | 0.09 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.14 | 0.09 | -0.04 | hold |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 200,000 | 200,000 | 0 | 1.34 | 1.18 | -0.16 | hold |
| MACQUARIE GROUP LTD | 180,000 | 180,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 126,485 | 179,276 | +52,791 | 0.03 | 0.02 | -0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 178,289 | +178,289 | 0.00 | 0.02 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 400 | 176,030 | +175,630 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 92,216 | 167,493 | +75,277 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 149,400 | 164,300 | +14,900 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 122,258 | 160,918 | +38,660 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 39,209 | 160,327 | +121,118 | 0.02 | 0.06 | +0.04 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 250,000 | 155,000 | -95,000 | 0.01 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 42,960 | 154,406 | +111,446 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 925,000 | 150,000 | -775,000 | 2.34 | 0.28 | -2.06 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,107 | 141,113 | +77,006 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 128,845 | +128,845 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 120,810 | 128,732 | +7,922 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 145,034 | 127,111 | -17,923 | 0.01 | 0.01 | -0.01 | sell |
| Russell Investments Group, Ltd. | 117,613 | 126,158 | +8,545 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,817,009 | 126,145 | -1,690,864 | 0.06 | 0.00 | -0.05 | sell |
| Rafferty Asset Management, LLC | 171,541 | 126,045 | -45,496 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 35,037 | 125,345 | +90,308 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 57,565 | 122,163 | +64,598 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 168,684 | 117,649 | -51,035 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 255,832 | 112,794 | -143,038 | 0.06 | 0.02 | -0.03 | sell |
| CITIGROUP INC | 200,650 | 111,752 | -88,898 | 0.00 | 0.00 | -0.00 | sell |
| Yelin Lapidot Holdings Management Ltd. | 108,377 | 108,377 | 0 | 0.26 | 0.19 | -0.07 | hold |
| HSBC HOLDINGS PLC | 50,275 | 106,787 | +56,512 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 76,848 | 105,157 | +28,309 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 106,628 | 97,113 | -9,515 | 0.04 | 0.02 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 34,228 | 96,674 | +62,446 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 92,900 | +92,900 | 0.00 | 0.86 | +0.86 | buy |