| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,254,426 | 9,020,006 | +765,580 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 8,050,959 | 8,050,959 | 0 | 11.94 | 9.73 | -2.21 | hold |
| GOLDMAN SACHS GROUP INC | 4,996,787 | 5,861,265 | +864,478 | 0.02 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 4,430,076 | 5,658,424 | +1,228,348 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 4,249,836 | 4,045,094 | -204,742 | 0.01 | 0.01 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,779,900 | 3,779,900 | 0 | 1.04 | 0.86 | -0.18 | hold |
| Eversept Partners, LP | 2,885,622 | 2,798,210 | -87,412 | 4.44 | 3.33 | -1.11 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,157,058 | 2,584,136 | +427,078 | 0.00 | 0.00 | -0.00 | buy |
| Hood River Capital Management LLC | 2,354,285 | 2,564,279 | +209,994 | 0.55 | 0.41 | -0.14 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,500,000 | 2,500,000 | 0 | 9.78 | 7.37 | -2.41 | hold |
| FRANKLIN RESOURCES INC | 2,150,079 | 2,286,499 | +136,420 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 199,524 | 2,053,960 | +1,854,436 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 1,153,662 | 1,893,750 | +740,088 | 0.00 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,732,541 | 1,790,173 | +57,632 | 0.05 | 0.04 | -0.01 | buy |
| Candriam S.C.A. | 925,332 | 1,696,040 | +770,708 | 0.11 | 0.17 | +0.05 | buy |
| Soleus Capital Management, L.P. | 1,726,908 | 1,628,039 | -98,869 | 1.63 | 1.23 | -0.41 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,579,596 | 1,578,125 | -1,471 | 0.03 | 0.03 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 962,300 | 1,542,000 | +579,700 | 0.49 | 0.64 | +0.15 | buy |
| Nuveen, LLC | 1,494,645 | 1,364,575 | -130,070 | 0.01 | 0.01 | -0.00 | sell |
| MPM BioImpact LLC | 1,340,733 | 1,333,523 | -7,210 | 2.42 | 1.78 | -0.64 | sell |
| Aisling Capital Management LP | 1,316,806 | 1,316,806 | 0 | 6.46 | 6.10 | -0.35 | hold |
| Woodline Partners LP | 1,250,760 | 1,250,760 | 0 | 0.11 | 0.08 | -0.03 | hold |
| D. E. Shaw & Co., Inc. | 1,601,896 | 1,239,954 | -361,942 | 0.03 | 0.02 | -0.01 | sell |
| Catalio Capital Management, LP | 1,043,670 | 1,215,698 | +172,028 | 5.09 | 4.99 | -0.10 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 888,987 | 1,214,390 | +325,403 | 2.45 | 2.95 | +0.51 | buy |
| Prosight Management, LP | 770,000 | 1,200,000 | +430,000 | 2.95 | 4.52 | +1.57 | buy |
| ALGERT GLOBAL LLC | 928,568 | 1,051,465 | +122,897 | 0.33 | 0.27 | -0.05 | buy |
| Bank of New York Mellon Corp | 1,004,498 | 1,040,079 | +35,581 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 724,563 | 1,014,606 | +290,043 | 2.91 | 3.17 | +0.26 | buy |
| LOOMIS SAYLES & CO L P | 0 | 923,624 | +923,624 | 0.00 | 0.03 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 901,511 | 877,256 | -24,255 | 2.18 | 1.97 | -0.21 | sell |
| Ensign Peak Advisors, Inc | 990,969 | 867,831 | -123,138 | 0.04 | 0.03 | -0.01 | sell |
| Palo Alto Investors LP | 864,986 | 864,986 | 0 | 3.09 | 2.61 | -0.48 | hold |
| AQR CAPITAL MANAGEMENT LLC | 980,314 | 853,304 | -127,010 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 755,719 | 845,537 | +89,818 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 814,303 | +814,303 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 715,153 | 814,303 | +99,150 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 893,933 | 588,979 | -304,954 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 379,250 | 560,250 | +181,000 | 1.09 | 1.16 | +0.06 | buy |
| APIS CAPITAL ADVISORS, LLC | 550,000 | 556,000 | +6,000 | 1.98 | 1.18 | -0.80 | buy |
| PANAGORA ASSET MANAGEMENT INC | 249,407 | 546,517 | +297,110 | 0.02 | 0.04 | +0.01 | buy |
| Qube Research & Technologies Ltd | 36,047 | 477,182 | +441,135 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 456,700 | +456,700 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 196,621 | 454,101 | +257,480 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 306,321 | 446,988 | +140,667 | 0.35 | 0.35 | +0.00 | buy |
| Knott David M Jr | 422,000 | 437,245 | +15,245 | 5.87 | 5.05 | -0.81 | buy |
| Jump Financial, LLC | 0 | 402,846 | +402,846 | 0.00 | 0.08 | +0.08 | buy |
| Aberdeen Group plc | 286,969 | 372,766 | +85,797 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 181,552 | 370,317 | +188,765 | 0.01 | 0.02 | +0.01 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 366,568 | +366,568 | 0.00 | 0.04 | +0.04 | buy |
| HRT FINANCIAL LP | 88,904 | 363,147 | +274,243 | 0.01 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 284,245 | 346,852 | +62,607 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 214,807 | 342,883 | +128,076 | 0.17 | 0.21 | +0.05 | buy |
| DAFNA Capital Management LLC | 217,355 | 335,255 | +117,900 | 1.16 | 1.40 | +0.24 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 41,872 | 327,617 | +285,745 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 498,200 | 321,600 | -176,600 | 0.02 | 0.01 | -0.01 | sell |
| Brevan Howard Capital Management LP | 204,845 | 309,065 | +104,220 | 0.05 | 0.09 | +0.05 | buy |
| Alyeska Investment Group, L.P. | 0 | 308,507 | +308,507 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 304,939 | +304,939 | 0.00 | 0.05 | +0.05 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 280,079 | +280,079 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 630,942 | 258,278 | -372,664 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 201,777 | 255,949 | +54,172 | 0.03 | 0.03 | +0.00 | buy |
| SECTOR GAMMA AS | 286,007 | 241,739 | -44,268 | 1.58 | 1.15 | -0.43 | sell |
| Schonfeld Strategic Advisors LLC | 260,626 | 236,717 | -23,909 | 0.05 | 0.03 | -0.02 | sell |
| JPMORGAN CHASE & CO | 258,519 | 231,446 | -27,073 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 182,016 | 213,703 | +31,687 | 0.01 | 0.01 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 212,713 | +212,713 | 0.00 | 0.09 | +0.09 | buy |
| Pictet Asset Management Holding SA | 12,356 | 207,936 | +195,580 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 331,665 | 207,250 | -124,415 | 0.01 | 0.01 | -0.01 | sell |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 200,000 | 200,000 | 0 | 1.78 | 1.15 | -0.63 | hold |
| CITIGROUP INC | 20,332 | 195,703 | +175,371 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 217,600 | 193,134 | -24,466 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 161,400 | 168,100 | +6,700 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 155,965 | 162,524 | +6,559 | 0.26 | 0.32 | +0.06 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 149,797 | 161,323 | +11,526 | 0.00 | 0.00 | -0.00 | buy |
| SummitTX Capital, L.P. | 66,340 | 140,797 | +74,457 | 0.05 | 0.08 | +0.03 | buy |
| Invesco Ltd. | 252,761 | 138,060 | -114,701 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 101,492 | 134,993 | +33,501 | 0.00 | 0.00 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 104,868 | 133,835 | +28,967 | 0.36 | 0.39 | +0.04 | buy |
| RHUMBLINE ADVISERS | 114,762 | 132,358 | +17,596 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 80,394 | 130,054 | +49,660 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 107,133 | 128,199 | +21,066 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 284,460 | 125,550 | -158,910 | 0.58 | 0.20 | -0.39 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 145,566 | 125,091 | -20,475 | 0.03 | 0.02 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 123,586 | 124,241 | +655 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 245,021 | 118,422 | -126,599 | 0.60 | 0.22 | -0.38 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 115,208 | +115,208 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 288,567 | 106,040 | -182,527 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 124,723 | 97,787 | -26,936 | 0.01 | 0.00 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 74,983 | 95,315 | +20,332 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 103,009 | 93,481 | -9,528 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 84,000 | +84,000 | 0.00 | 0.42 | +0.42 | buy |
| Aquatic Capital Management LLC | 69,083 | 78,922 | +9,839 | 0.05 | 0.06 | +0.01 | buy |
| WINTON GROUP Ltd | 10,300 | 76,500 | +66,200 | 0.01 | 0.05 | +0.05 | buy |
| Tidal Investments LLC | 65,326 | 72,212 | +6,886 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 58,348 | 72,212 | +13,864 | 0.09 | 0.05 | -0.04 | buy |
| 1492 Capital Management LLC | 0 | 66,997 | +66,997 | 0.00 | 0.43 | +0.43 | buy |
| Legal & General Group Plc | 59,058 | 65,483 | +6,425 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 41,445 | 63,720 | +22,275 | 0.27 | 0.32 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 48,554 | 62,775 | +14,221 | 0.07 | 0.09 | +0.02 | buy |