| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hudson Bay Capital Management LP | 475,000 | 1,236,186 | +761,186 | 0.10 | 0.17 | +0.07 | buy |
| Saturn V Capital Management LP | 173,717 | 807,969 | +634,252 | 2.02 | 4.91 | +2.89 | buy |
| PFM Health Sciences, LP | 2,172,437 | 2,715,235 | +542,798 | 1.83 | 1.89 | +0.06 | buy |
| Eversept Partners, LP | 2,189,732 | 2,596,245 | +406,513 | 4.84 | 4.19 | -0.65 | buy |
| Kynam Capital Management, LP | 3,262,004 | 3,600,000 | +337,996 | 10.46 | 8.69 | -1.77 | buy |
| ALGERT GLOBAL LLC | 253,631 | 456,219 | +202,588 | 0.23 | 0.31 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 925,000 | 1,000,000 | +75,000 | 0.04 | 0.03 | -0.01 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 37,004 | 88,208 | +51,204 | 0.08 | 0.17 | +0.09 | buy |
| ExodusPoint Capital Management, LP | 205,718 | 155,714 | +50,004 | 0.05 | 0.03 | 0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 723,061 | 773,061 | +50,000 | 3.24 | 2.69 | -0.55 | buy |
| TWINBEECH CAPITAL LP | 150,196 | 188,110 | +37,914 | 0.06 | 0.05 | -0.01 | buy |
| Crestline Management, LP | 112,464 | 134,464 | +22,000 | 0.26 | 0.23 | -0.02 | buy |
| DAFNA Capital Management LLC | 450,873 | 458,373 | +7,500 | 2.58 | 2.07 | -0.51 | buy |
| Parkman Healthcare Partners LLC | 208,266 | 212,448 | +4,182 | 0.76 | 0.57 | -0.19 | buy |
| China Universal Asset Management Co., Ltd. | 902 | 1,782 | +880 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 50,585 | 51,236 | +651 | 0.01 | 0.01 | -0.00 | buy |
| Simplify Asset Management Inc. | 12,809 | 12,665 | -144 | 0.05 | 0.03 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 4,983 | 4,532 | -451 | 0.06 | 0.04 | -0.02 | sell |
| Sandia Investment Management LP | 5,000 | 3,000 | -2,000 | 0.03 | 0.01 | -0.02 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 299,841 | 297,035 | -2,806 | 4.25 | 3.14 | -1.12 | sell |
| E Fund Management Co., Ltd. | 18,027 | 14,594 | -3,433 | 0.03 | 0.02 | -0.01 | sell |
| HighVista Strategies LLC | 33,576 | 29,490 | -4,086 | 0.32 | 0.20 | -0.12 | sell |
| Inspire Investing, LLC | 28,768 | 21,095 | -7,673 | 0.07 | 0.04 | -0.03 | sell |
| PROFUND ADVISORS LLC | 60,841 | 48,042 | -12,799 | 0.07 | 0.04 | -0.03 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 233,738 | 219,974 | -13,764 | 0.13 | 0.10 | -0.04 | sell |
| AXIOM INVESTORS LLC /DE | 30,110 | 10,820 | -19,290 | 0.01 | 0.00 | -0.01 | sell |
| Inspire Advisors, LLC | 41,282 | 20,561 | -20,721 | 0.17 | 0.05 | -0.11 | sell |
| Paradigm Biocapital Advisors LP | 2,424,132 | 2,390,077 | -34,055 | 4.11 | 2.37 | -1.74 | sell |
| Commodore Capital LP | 997,596 | 957,509 | -40,087 | 2.35 | 1.63 | -0.72 | sell |
| Avidity Partners Management LP | 2,872,000 | 2,821,000 | -51,000 | 2.10 | 1.65 | -0.45 | sell |
| Rafferty Asset Management, LLC | 335,347 | 284,124 | -51,223 | 0.04 | 0.02 | -0.02 | sell |
| Nantahala Capital Management, LLC | 323,134 | 240,031 | -83,103 | 0.82 | 0.44 | -0.38 | sell |
| Soleus Capital Management, L.P. | 212,600 | 119,500 | -93,100 | 0.49 | 0.17 | -0.32 | sell |
| Avoro Capital Advisors LLC | 2,650,000 | 2,555,555 | -94,445 | 0.75 | 0.58 | -0.17 | sell |
| Palo Alto Investors LP | 612,600 | 472,600 | -140,000 | 1.04 | 0.65 | -0.39 | sell |
| LORD, ABBETT & CO. LLC | 365,172 | 212,967 | -152,205 | 0.03 | 0.01 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 2,521,916 | 2,347,673 | -174,243 | 0.04 | 0.03 | -0.01 | sell |
| Woodline Partners LP | 612,316 | 34,067 | -578,249 | 0.15 | 0.01 | -0.15 | sell |
| Sofinnova Investments, Inc. | 1,582,291 | 941,817 | -640,474 | 2.19 | 0.95 | -1.24 | sell |
| ORBIMED ADVISORS LLC | 2,530,240 | 1,284,000 | -1,246,240 | 0.97 | 0.40 | -0.57 | sell |
| Frazier Life Sciences Management, L.P. | 3,708,838 | 600,000 | -3,108,838 | 4.64 | 0.58 | -4.06 | sell |