| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BNP Paribas Asset Management Holding S.A. | 0 | 787,785 | +787,785 | 0.00 | 0.04 | +0.04 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 786,990 | +786,990 | 0.00 | 0.26 | +0.26 | buy |
| First Turn Management, LLC | 640,389 | 1,187,165 | +546,776 | 2.14 | 3.62 | +1.48 | buy |
| Polar Capital Holdings Plc | 0 | 500,000 | +500,000 | 0.00 | 0.05 | +0.05 | buy |
| Eversept Partners, LP | 3,613,631 | 4,105,313 | +491,682 | 5.68 | 6.06 | +0.38 | buy |
| Hudson Bay Capital Management LP | 0 | 425,000 | +425,000 | 0.00 | 0.06 | +0.06 | buy |
| Qube Research & Technologies Ltd | 297,303 | 683,202 | +385,899 | 0.01 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 367,177 | +367,177 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 1,545,528 | 1,896,032 | +350,504 | 0.30 | 0.31 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 350,206 | +350,206 | 0.00 | 1.13 | +1.13 | buy |
| Casdin Capital, LLC | 150,000 | 475,000 | +325,000 | 0.24 | 0.61 | +0.37 | buy |
| STEMPOINT CAPITAL LP | 1,412,176 | 1,731,191 | +319,015 | 8.53 | 9.99 | +1.47 | buy |
| Crestline Management, LP | 143,280 | 428,538 | +285,258 | 0.23 | 0.47 | +0.24 | buy |
| FEDERATED HERMES, INC. | 656,250 | 937,250 | +281,000 | 0.03 | 0.04 | +0.01 | buy |
| Soleus Capital Management, L.P. | 826,500 | 1,090,984 | +264,484 | 1.50 | 1.75 | +0.25 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 822,047 | 1,034,846 | +212,799 | 2.75 | 3.26 | +0.51 | buy |
| FRANKLIN RESOURCES INC | 1,555,234 | 1,763,277 | +208,043 | 0.01 | 0.01 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 146,643 | 352,358 | +205,715 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,444,012 | 1,612,052 | +168,040 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,622,335 | 3,770,826 | +148,491 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 756,232 | 887,145 | +130,913 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 5,722,057 | 5,842,925 | +120,868 | 12.30 | 8.72 | -3.58 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 0 | 116,812 | +116,812 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 77,094 | 187,629 | +110,535 | 0.00 | 0.00 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 894,993 | 1,000,000 | +105,007 | 2.84 | 2.83 | -0.01 | buy |
| VANGUARD GROUP INC | 4,797,089 | 4,886,974 | +89,885 | 0.00 | 0.00 | -0.00 | buy |
| Saturn V Capital Management LP | 419,654 | 501,978 | +82,324 | 3.26 | 3.45 | +0.20 | buy |
| Granahan Investment Management, LLC | 594,386 | 664,765 | +70,379 | 0.49 | 0.50 | +0.02 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,027 | 168,706 | +66,679 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,910,623 | 1,977,082 | +66,459 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 19,386 | 81,302 | +61,916 | 0.02 | 0.10 | +0.07 | buy |
| Commodore Capital LP | 825,000 | 885,000 | +60,000 | 1.16 | 1.06 | -0.09 | buy |
| Jump Financial, LLC | 37,500 | 96,191 | +58,691 | 0.02 | 0.04 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 57,565 | +57,565 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,065,508 | 1,119,963 | +54,455 | 0.02 | 0.02 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 53,426 | +53,426 | 0.00 | 0.01 | +0.01 | buy |
| Propel Bio Management, LLC | 83,259 | 133,259 | +50,000 | 1.11 | 1.49 | +0.38 | buy |
| TWO SIGMA ADVISERS, LP | 621,252 | 669,352 | +48,100 | 0.03 | 0.03 | +0.00 | buy |
| Simplify Asset Management Inc. | 75,193 | 122,185 | +46,992 | 0.14 | 0.16 | +0.03 | buy |
| ALGERT GLOBAL LLC | 432,128 | 474,998 | +42,870 | 0.30 | 0.25 | -0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 654,489 | 695,947 | +41,458 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 696,729 | 737,606 | +40,877 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 38,165 | +38,165 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 428,949 | 466,028 | +37,079 | 0.02 | 0.02 | -0.00 | buy |
| PFM Health Sciences, LP | 387,357 | 423,910 | +36,553 | 0.43 | 0.47 | +0.03 | buy |
| Rhenman & Partners Asset Management AB | 228,500 | 259,500 | +31,000 | 0.45 | 0.41 | -0.04 | buy |
| TWINBEECH CAPITAL LP | 167,714 | 198,579 | +30,865 | 0.07 | 0.07 | +0.01 | buy |
| Candriam S.C.A. | 970,106 | 998,619 | +28,513 | 0.12 | 0.11 | -0.01 | buy |
| CITIGROUP INC | 36,352 | 60,936 | +24,584 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 22,685 | +22,685 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 22,282 | +22,282 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 21,849 | +21,849 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 125,152 | 146,438 | +21,286 | 0.00 | 0.00 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 95,140 | 115,642 | +20,502 | 0.02 | 0.02 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 20,346 | +20,346 | 0.00 | 0.15 | +0.15 | buy |
| Caption Management, LLC | 0 | 20,326 | +20,326 | 0.00 | 0.04 | +0.04 | buy |
| Atria Investments, Inc | 0 | 18,928 | +18,928 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 103,826 | 122,144 | +18,318 | 0.85 | 0.83 | -0.02 | buy |
| Nebula Research & Development LLC | 0 | 18,070 | +18,070 | 0.00 | 0.04 | +0.04 | buy |
| STIFEL FINANCIAL CORP | 0 | 16,976 | +16,976 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,436 | 21,099 | +16,663 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 53,189 | 66,270 | +13,081 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 36,871 | 49,248 | +12,377 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 10,200 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,873 | 15,980 | +10,107 | 0.00 | 0.01 | +0.01 | buy |
| Long Corridor Asset Management Ltd | 0 | 10,000 | +10,000 | 0.00 | 0.17 | +0.17 | buy |
| GROUP ONE TRADING LLC | 2,318 | 11,752 | +9,434 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 370,000 | 378,746 | +8,746 | 1.88 | 1.64 | -0.23 | buy |
| BIT Capital GmbH | 79,786 | 87,997 | +8,211 | 0.15 | 0.16 | +0.01 | buy |
| Legal & General Group Plc | 74,425 | 80,938 | +6,513 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,984 | 16,367 | +6,383 | 0.03 | 0.03 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 6,200 | +6,200 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 45,928 | 50,493 | +4,565 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 47,373 | 51,937 | +4,564 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 13,635 | 17,858 | +4,223 | 0.04 | 0.03 | -0.01 | buy |
| DnB Asset Management AS | 13,172 | 17,362 | +4,190 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 17,290 | 21,308 | +4,018 | 0.04 | 0.04 | +0.00 | buy |
| Prosight Management, LP | 551,544 | 554,103 | +2,559 | 3.38 | 2.70 | -0.68 | buy |
| Quantbot Technologies LP | 0 | 2,542 | +2,542 | 0.00 | 0.00 | +0.00 | buy |
| Cape Investment Advisory, Inc. | 0 | 2,500 | +2,500 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16,795 | 19,184 | +2,389 | 0.00 | 0.00 | -0.00 | buy |
| Values First Advisors, Inc. | 0 | 1,546 | +1,546 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 8,215 | 9,377 | +1,162 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 33,231 | 34,161 | +930 | 0.03 | 0.02 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,509 | 2,411 | +902 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 48,198 | 48,927 | +729 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 21,407 | 22,025 | +618 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 50,061 | 50,640 | +579 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,537 | 3,078 | +541 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 517 | +517 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 94,313 | 94,772 | +459 | 0.01 | 0.01 | -0.00 | buy |
| MACQUARIE GROUP LTD | 242,919 | 243,352 | +433 | 0.01 | 0.01 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 198,659 | 199,086 | +427 | 0.12 | 0.12 | -0.00 | buy |
| HSBC HOLDINGS PLC | 43,597 | 44,006 | +409 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 3,544 | 3,860 | +316 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 253 | 495 | +242 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 236 | +236 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 13,283 | 13,514 | +231 | 0.00 | 0.00 | -0.00 | buy |