| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 5,722,057 | 5,842,925 | +120,868 | 12.30 | 8.72 | -3.58 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,339,004 | 4,985,976 | -2,353,028 | 0.03 | 0.02 | -0.01 | sell |
| VANGUARD GROUP INC | 4,797,089 | 4,886,974 | +89,885 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 3,613,631 | 4,105,313 | +491,682 | 5.68 | 6.06 | +0.38 | buy |
| Avoro Capital Advisors LLC | 3,888,437 | 3,888,437 | 0 | 1.06 | 1.09 | +0.03 | hold |
| STATE STREET CORP | 3,622,335 | 3,770,826 | +148,491 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 2,782,853 | 2,778,267 | -4,586 | 0.18 | 0.19 | +0.00 | sell |
| Avidity Partners Management LP | 3,335,000 | 2,455,000 | -880,000 | 2.91 | 2.41 | -0.50 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,910,623 | 1,977,082 | +66,459 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 1,925,300 | 1,925,300 | 0 | 0.79 | 0.68 | -0.11 | hold |
| Woodline Partners LP | 1,545,528 | 1,896,032 | +350,504 | 0.30 | 0.31 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,555,234 | 1,763,277 | +208,043 | 0.01 | 0.01 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 1,412,176 | 1,731,191 | +319,015 | 8.53 | 9.99 | +1.47 | buy |
| GOLDMAN SACHS GROUP INC | 1,444,012 | 1,612,052 | +168,040 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 640,389 | 1,187,165 | +546,776 | 2.14 | 3.62 | +1.48 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,065,508 | 1,119,963 | +54,455 | 0.02 | 0.02 | +0.00 | buy |
| Soleus Capital Management, L.P. | 826,500 | 1,090,984 | +264,484 | 1.50 | 1.75 | +0.25 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 822,047 | 1,034,846 | +212,799 | 2.75 | 3.26 | +0.51 | buy |
| Aisling Capital Management LP | 1,025,000 | 1,025,000 | 0 | 9.11 | 7.56 | -1.55 | hold |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 894,993 | 1,000,000 | +105,007 | 2.84 | 2.83 | -0.01 | buy |
| Candriam S.C.A. | 970,106 | 998,619 | +28,513 | 0.12 | 0.11 | -0.01 | buy |
| MARSHALL WACE, LLP | 1,830,427 | 989,904 | -840,523 | 0.05 | 0.02 | -0.03 | sell |
| FEDERATED HERMES, INC. | 656,250 | 937,250 | +281,000 | 0.03 | 0.04 | +0.01 | buy |
| MORGAN STANLEY | 756,232 | 887,145 | +130,913 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 930,947 | 886,494 | -44,453 | 0.05 | 0.04 | -0.01 | sell |
| Commodore Capital LP | 825,000 | 885,000 | +60,000 | 1.16 | 1.06 | -0.09 | buy |
| Foresite Capital Management IV, LLC | 875,000 | 875,000 | 0 | 12.07 | 11.01 | -1.06 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 860,000 | 817,600 | -42,400 | 0.03 | 0.03 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 0 | 787,785 | +787,785 | 0.00 | 0.04 | +0.04 | buy |
| Sofinnova Investments, Inc. | 2,153,669 | 786,999 | -1,366,670 | 2.79 | 1.25 | -1.53 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 786,990 | +786,990 | 0.00 | 0.26 | +0.26 | buy |
| BANK OF AMERICA CORP /DE/ | 852,206 | 757,307 | -94,899 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 696,729 | 737,606 | +40,877 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 654,489 | 695,947 | +41,458 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 297,303 | 683,202 | +385,899 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 621,252 | 669,352 | +48,100 | 0.03 | 0.03 | +0.00 | buy |
| Granahan Investment Management, LLC | 594,386 | 664,765 | +70,379 | 0.49 | 0.50 | +0.02 | buy |
| JPMORGAN CHASE & CO | 629,880 | 627,679 | -2,201 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 551,544 | 554,103 | +2,559 | 3.38 | 2.70 | -0.68 | buy |
| DAFNA Capital Management LLC | 657,074 | 526,702 | -130,372 | 3.22 | 2.40 | -0.83 | sell |
| Parkman Healthcare Partners LLC | 600,698 | 508,283 | -92,415 | 1.68 | 1.25 | -0.43 | sell |
| Saturn V Capital Management LP | 419,654 | 501,978 | +82,324 | 3.26 | 3.45 | +0.20 | buy |
| Polar Capital Holdings Plc | 0 | 500,000 | +500,000 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 521,080 | 486,228 | -34,852 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 150,000 | 475,000 | +325,000 | 0.24 | 0.61 | +0.37 | buy |
| ALGERT GLOBAL LLC | 432,128 | 474,998 | +42,870 | 0.30 | 0.25 | -0.05 | buy |
| Assenagon Asset Management S.A. | 428,949 | 466,028 | +37,079 | 0.02 | 0.02 | -0.00 | buy |
| Nantahala Capital Management, LLC | 453,232 | 453,232 | 0 | 0.93 | 0.73 | -0.20 | hold |
| Crestline Management, LP | 143,280 | 428,538 | +285,258 | 0.23 | 0.47 | +0.24 | buy |
| Hudson Bay Capital Management LP | 0 | 425,000 | +425,000 | 0.00 | 0.06 | +0.06 | buy |
| PFM Health Sciences, LP | 387,357 | 423,910 | +36,553 | 0.43 | 0.47 | +0.03 | buy |
| Palo Alto Investors LP | 405,193 | 405,193 | 0 | 0.96 | 1.01 | +0.05 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 370,000 | 378,746 | +8,746 | 1.88 | 1.64 | -0.23 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 367,177 | +367,177 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 518,885 | 361,825 | -157,060 | 0.02 | 0.01 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 146,643 | 352,358 | +205,715 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 350,206 | +350,206 | 0.00 | 1.13 | +1.13 | buy |
| ExodusPoint Capital Management, LP | 625,723 | 318,394 | -307,329 | 0.14 | 0.06 | -0.08 | sell |
| Rhenman & Partners Asset Management AB | 228,500 | 259,500 | +31,000 | 0.45 | 0.41 | -0.04 | buy |
| MACQUARIE GROUP LTD | 242,919 | 243,352 | +433 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 291,826 | 221,502 | -70,324 | 0.00 | 0.00 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 198,659 | 199,086 | +427 | 0.12 | 0.12 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 167,714 | 198,579 | +30,865 | 0.07 | 0.07 | +0.01 | buy |
| BARCLAYS PLC | 77,094 | 187,629 | +110,535 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 260,876 | 187,463 | -73,413 | 0.04 | 0.03 | -0.01 | sell |
| Rafferty Asset Management, LLC | 177,920 | 171,522 | -6,398 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,027 | 168,706 | +66,679 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 150,600 | 149,400 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 125,152 | 146,438 | +21,286 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 153,360 | 137,447 | -15,913 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 153,311 | 133,541 | -19,770 | 0.00 | 0.00 | +0.00 | sell |
| Propel Bio Management, LLC | 83,259 | 133,259 | +50,000 | 1.11 | 1.49 | +0.38 | buy |
| Simplify Asset Management Inc. | 75,193 | 122,185 | +46,992 | 0.14 | 0.16 | +0.03 | buy |
| Knott David M Jr | 103,826 | 122,144 | +18,318 | 0.85 | 0.83 | -0.02 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 0 | 116,812 | +116,812 | 0.00 | 0.03 | +0.03 | buy |
| AXIOM INVESTORS LLC /DE | 95,140 | 115,642 | +20,502 | 0.02 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 119,285 | 114,459 | -4,826 | 0.00 | 0.00 | -0.00 | sell |
| Yelin Lapidot Holdings Management Ltd. | 114,530 | 108,377 | -6,153 | 0.41 | 0.34 | -0.07 | sell |
| Jump Financial, LLC | 37,500 | 96,191 | +58,691 | 0.02 | 0.04 | +0.02 | buy |
| State of New Jersey Common Pension Fund D | 94,313 | 94,772 | +459 | 0.01 | 0.01 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 183,649 | 94,183 | -89,466 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 110,454 | 89,481 | -20,973 | 0.06 | 0.04 | -0.02 | sell |
| BIT Capital GmbH | 79,786 | 87,997 | +8,211 | 0.15 | 0.16 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 283,827 | 85,511 | -198,316 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 85,250 | 85,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 19,386 | 81,302 | +61,916 | 0.02 | 0.10 | +0.07 | buy |
| Legal & General Group Plc | 74,425 | 80,938 | +6,513 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 144,566 | 79,341 | -65,225 | 0.02 | 0.01 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,346 | 72,761 | -2,585 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 66,293 | 66,403 | +110 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 53,189 | 66,270 | +13,081 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 36,352 | 60,936 | +24,584 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 75,840 | 59,411 | -16,429 | 0.04 | 0.02 | -0.01 | sell |
| Graham Capital Management, L.P. | 75,651 | 57,939 | -17,712 | 0.05 | 0.04 | -0.02 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 57,565 | +57,565 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 53,426 | +53,426 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 47,373 | 51,937 | +4,564 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 50,061 | 50,640 | +579 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 45,928 | 50,493 | +4,565 | 0.00 | 0.00 | -0.00 | buy |