| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| First Turn Management, LLC | 640,389 | 1,187,165 | +546,776 | 2.14 | 3.62 | +1.48 | buy |
| Eversept Partners, LP | 3,613,631 | 4,105,313 | +491,682 | 5.08 | 5.41 | +0.33 | buy |
| Woodline Partners LP | 1,545,528 | 1,896,032 | +350,504 | 0.30 | 0.31 | +0.00 | buy |
| Casdin Capital, LLC | 150,000 | 475,000 | +325,000 | 0.27 | 0.61 | +0.34 | buy |
| STEMPOINT CAPITAL LP | 1,412,176 | 1,731,191 | +319,015 | 8.53 | 9.99 | +1.47 | buy |
| ExodusPoint Capital Management, LP | 625,723 | 318,394 | +307,329 | 0.14 | 0.06 | 0.00 | sell |
| Crestline Management, LP | 143,280 | 428,538 | +285,258 | 0.23 | 0.43 | +0.20 | buy |
| Soleus Capital Management, L.P. | 826,500 | 1,090,984 | +264,484 | 1.50 | 1.75 | +0.25 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 822,047 | 1,034,846 | +212,799 | 2.30 | 3.17 | +0.87 | buy |
| Kynam Capital Management, LP | 5,722,057 | 5,842,925 | +120,868 | 12.30 | 8.72 | -3.58 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 894,993 | 1,000,000 | +105,007 | 2.84 | 2.83 | -0.01 | buy |
| Saturn V Capital Management LP | 419,654 | 501,978 | +82,324 | 3.26 | 3.45 | +0.20 | buy |
| Granahan Investment Management, LLC | 594,386 | 664,765 | +70,379 | 0.49 | 0.50 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 19,386 | 81,302 | +61,916 | 0.02 | 0.10 | 0.00 | buy |
| Commodore Capital LP | 825,000 | 885,000 | +60,000 | 1.16 | 1.06 | -0.09 | buy |
| Propel Bio Management, LLC | 83,259 | 133,259 | +50,000 | 1.11 | 1.49 | +0.38 | buy |
| Simplify Asset Management Inc. | 75,193 | 122,185 | +46,992 | 0.14 | 0.16 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 930,947 | 886,494 | +44,453 | 0.05 | 0.04 | 0.00 | sell |
| ALGERT GLOBAL LLC | 432,128 | 474,998 | +42,870 | 0.31 | 0.25 | 0.00 | buy |
| PFM Health Sciences, LP | 387,357 | 423,910 | +36,553 | 0.39 | 0.46 | +0.07 | buy |
| Rhenman & Partners Asset Management AB | 228,500 | 259,500 | +31,000 | 0.45 | 0.41 | -0.04 | buy |
| TWINBEECH CAPITAL LP | 167,714 | 198,579 | +30,865 | 0.07 | 0.07 | +0.01 | buy |
| Candriam S.C.A. | 970,106 | 998,619 | +28,513 | 0.12 | 0.11 | -0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 110,454 | 89,481 | +20,973 | 0.14 | 0.14 | 0.00 | sell |
| AXIOM INVESTORS LLC /DE | 95,140 | 115,642 | +20,502 | 0.02 | 0.02 | +0.00 | buy |
| Knott David M Jr | 103,826 | 122,144 | +18,318 | 0.85 | 0.83 | -0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 370,000 | 378,746 | +8,746 | 1.88 | 1.64 | -0.23 | buy |
| BIT Capital GmbH | 79,786 | 87,997 | +8,211 | 0.13 | 0.16 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 9,984 | 16,367 | +6,383 | 0.03 | 0.03 | +0.01 | buy |
| AlphaQuest LLC | 13,635 | 17,858 | +4,223 | 0.04 | 0.03 | 0.00 | buy |
| DnB Asset Management AS | 13,172 | 17,362 | +4,190 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 17,290 | 21,308 | +4,018 | 0.04 | 0.04 | +0.00 | buy |
| Prosight Management, LP | 551,544 | 554,103 | +2,559 | 3.38 | 2.62 | -0.76 | buy |
| PROFUND ADVISORS LLC | 33,231 | 34,161 | +930 | 0.03 | 0.03 | 0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 198,659 | 199,086 | +427 | 0.12 | 0.12 | -0.00 | buy |
| E Fund Management Co., Ltd. | 10,806 | 11,020 | +214 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 66,293 | 66,403 | +110 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,373 | 4,451 | +78 | 0.04 | 0.04 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 213 | 272 | +59 | 0.00 | 0.00 | +0.00 | buy |
| MeadowBrook Investment Advisors LLC | 1,700 | 1,500 | -200 | 0.03 | 0.03 | -0.01 | sell |
| NVWM, LLC | 42,700 | 42,475 | -225 | 0.23 | 0.21 | -0.03 | sell |
| Yelin Lapidot Holdings Management Ltd. | 114,530 | 108,377 | -6,153 | 0.41 | 0.34 | -0.07 | sell |
| Rafferty Asset Management, LLC | 177,920 | 171,522 | -6,398 | 0.01 | 0.01 | -0.00 | sell |
| Lion Point Capital, LP | 65,000 | 46,200 | -18,800 | 2.43 | 1.98 | -0.45 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 55,835 | 29,956 | -25,879 | 0.22 | 0.13 | -0.09 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 860,000 | 817,600 | -42,400 | 0.03 | 0.03 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 600,698 | 508,283 | -92,415 | 1.68 | 1.25 | -0.43 | sell |
| DAFNA Capital Management LLC | 657,074 | 526,702 | -130,372 | 3.22 | 2.40 | -0.83 | sell |
| T. Rowe Price Investment Management, Inc. | 283,827 | 85,511 | -198,316 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 3,335,000 | 2,455,000 | -880,000 | 2.91 | 2.41 | -0.50 | sell |
| Sofinnova Investments, Inc. | 2,153,669 | 786,999 | -1,366,670 | 2.30 | 1.20 | -1.10 | sell |