| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 10,456,907 | 8,625,244 | -1,831,663 | 0.00 | 0.00 | +0.00 | sell |
| Kynam Capital Management, LP | 8,520,000 | 8,520,000 | 0 | 8.59 | 9.76 | +1.17 | hold |
| GOLDMAN SACHS GROUP INC | 5,797,195 | 5,486,434 | -310,761 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 5,033,934 | 5,138,617 | +104,683 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,127,467 | 4,255,047 | +2,127,580 | 0.05 | 0.14 | +0.10 | buy |
| STATE STREET CORP | 3,442,752 | 3,853,549 | +410,797 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 3,838,872 | 3,697,753 | -141,119 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 4,065,355 | 3,467,314 | -598,041 | 3.84 | 4.09 | +0.25 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,432,440 | 3,311,963 | +1,879,523 | 0.02 | 0.08 | +0.06 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,100,000 | 2,500,000 | +400,000 | 3.80 | 6.03 | +2.23 | buy |
| FRANKLIN RESOURCES INC | 2,359,677 | 2,390,561 | +30,884 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,049,350 | 2,091,331 | +41,981 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,092,110 | 2,012,110 | +920,000 | 0.71 | 1.65 | +0.95 | buy |
| Assenagon Asset Management S.A. | 2,039,987 | 1,784,139 | -255,848 | 0.03 | 0.04 | +0.01 | sell |
| UBS Group AG | 1,435,415 | 1,674,513 | +239,098 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,665,916 | 1,644,844 | -21,072 | 0.02 | 0.04 | +0.01 | sell |
| Catalio Capital Management, LP | 2,104,512 | 1,614,717 | -489,795 | 4.13 | 4.59 | +0.46 | sell |
| Woodline Partners LP | 1,892,751 | 1,550,520 | -342,231 | 0.09 | 0.11 | +0.02 | sell |
| Nuveen, LLC | 266,043 | 1,475,798 | +1,209,755 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 0 | 1,375,674 | +1,375,674 | 0.00 | 3.46 | +3.46 | buy |
| STEMPOINT CAPITAL LP | 2,372,634 | 1,366,205 | -1,006,429 | 7.15 | 4.24 | -2.92 | sell |
| Aisling Capital Management LP | 1,316,806 | 1,316,806 | 0 | 3.43 | 4.44 | +1.01 | hold |
| BNP Paribas Asset Management Holding S.A. | 1,445,440 | 1,236,077 | -209,363 | 0.03 | 0.05 | +0.02 | sell |
| MORGAN STANLEY | 849,236 | 1,199,296 | +350,060 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 644,542 | 1,077,585 | +433,043 | 0.01 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 237,101 | 1,052,335 | +815,234 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,598,613 | 1,046,456 | -552,157 | 0.01 | 0.01 | -0.00 | sell |
| Prosight Management, LP | 1,079,673 | 1,003,400 | -76,273 | 2.47 | 3.71 | +1.24 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,414,081 | 988,486 | -425,595 | 0.23 | 0.25 | +0.02 | sell |
| ALGERT GLOBAL LLC | 1,021,280 | 930,766 | -90,514 | 0.20 | 0.24 | +0.04 | sell |
| Candriam S.C.A. | 675,085 | 925,332 | +250,247 | 0.04 | 0.07 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 837,700 | 860,500 | +22,800 | 0.01 | 0.02 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 867,813 | 846,899 | -20,914 | 0.94 | 1.43 | +0.49 | sell |
| Ensign Peak Advisors, Inc | 689,064 | 809,064 | +120,000 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 770,451 | 776,686 | +6,235 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 167,493 | 738,266 | +570,773 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 712,310 | 719,034 | +6,724 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 556,971 | 712,659 | +155,688 | 0.01 | 0.02 | +0.01 | buy |
| Palo Alto Investors LP | 444,367 | 654,930 | +210,563 | 0.89 | 1.86 | +0.98 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 638,000 | +638,000 | 0.00 | 2.17 | +2.17 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 499,903 | 599,871 | +99,968 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 574,000 | 574,000 | 0 | 0.68 | 0.98 | +0.30 | hold |
| AQR CAPITAL MANAGEMENT LLC | 230,577 | 558,076 | +327,499 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 640,000 | 546,268 | -93,732 | 0.01 | 0.01 | +0.00 | sell |
| DAFNA Capital Management LLC | 543,602 | 500,702 | -42,900 | 1.41 | 1.90 | +0.50 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 402,964 | 463,708 | +60,744 | 0.77 | 1.03 | +0.26 | buy |
| Knott David M Jr | 352,778 | 428,000 | +75,222 | 1.50 | 2.76 | +1.26 | buy |
| Granahan Investment Management, LLC | 991,388 | 396,336 | -595,052 | 0.38 | 0.25 | -0.13 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,571,564 | 387,716 | -1,183,848 | 3.85 | 1.41 | -2.43 | sell |
| Zimmer Partners, LP | 605,800 | 383,100 | -222,700 | 0.13 | 0.14 | +0.01 | sell |
| TWO SIGMA ADVISERS, LP | 392,452 | 383,052 | -9,400 | 0.01 | 0.01 | +0.00 | sell |
| Aberdeen Group plc | 303,426 | 372,792 | +69,366 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 382,966 | 348,061 | -34,905 | 0.00 | 0.00 | +0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 178,289 | 341,194 | +162,905 | 0.02 | 0.05 | +0.03 | buy |
| Ikarian Capital, LLC | 0 | 333,733 | +333,733 | 0.00 | 1.04 | +1.04 | buy |
| Walleye Capital LLC | 226,015 | 297,658 | +71,643 | 0.02 | 0.04 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 128,845 | 261,933 | +133,088 | 0.04 | 0.10 | +0.06 | buy |
| PFM Health Sciences, LP | 0 | 256,488 | +256,488 | 0.00 | 0.34 | +0.34 | buy |
| JPMORGAN CHASE & CO | 272,874 | 253,850 | -19,024 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 443,300 | 250,000 | -193,300 | 0.03 | 0.02 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 176,030 | 246,779 | +70,749 | 0.02 | 0.05 | +0.04 | buy |
| MARSHALL WACE, LLP | 232,123 | 233,973 | +1,850 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 229,600 | +229,600 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 351,263 | 228,000 | -123,263 | 0.00 | 0.00 | -0.00 | sell |
| SECTOR GAMMA AS | 0 | 210,814 | +210,814 | 0.00 | 0.80 | +0.80 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.09 | 0.12 | +0.02 | hold |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 200,000 | 200,000 | 0 | 1.18 | 1.82 | +0.64 | hold |
| MACQUARIE GROUP LTD | 180,000 | 180,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Engineers Gate Manager LP | 179,276 | 179,366 | +90 | 0.02 | 0.03 | +0.01 | buy |
| Man Group plc | 228,167 | 174,951 | -53,216 | 0.00 | 0.01 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 160,327 | 160,327 | 0 | 0.06 | 0.04 | -0.02 | hold |
| Swiss National Bank | 164,300 | 158,500 | -5,800 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 155,316 | +155,316 | 0.00 | 0.01 | +0.01 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 127,111 | 148,139 | +21,028 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 126,045 | 141,822 | +15,777 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 256,138 | 134,261 | -121,877 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 105,157 | 133,091 | +27,934 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 381,035 | 132,701 | -248,334 | 0.05 | 0.03 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 264,744 | 132,123 | -132,621 | 0.02 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 128,732 | 131,669 | +2,937 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 130,000 | +130,000 | 0.00 | 1.88 | +1.88 | buy |
| ALLIANCEBERNSTEIN L.P. | 117,649 | 126,649 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 28,227 | 124,575 | +96,348 | 0.00 | 0.03 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 122,163 | 123,404 | +1,241 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 487,647 | 121,467 | -366,180 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 308,298 | 117,783 | -190,515 | 2.38 | 1.20 | -1.18 | sell |
| NEOS Investment Management LLC | 86,301 | 110,066 | +23,765 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 86,301 | 110,066 | +23,765 | 0.21 | 0.14 | -0.07 | buy |
| Yelin Lapidot Holdings Management Ltd. | 108,377 | 108,377 | 0 | 0.19 | 0.35 | +0.16 | hold |
| Y-Intercept (Hong Kong) Ltd | 276,932 | 100,851 | -176,081 | 0.06 | 0.04 | -0.03 | sell |
| SummitTX Capital, L.P. | 211,244 | 100,586 | -110,658 | 0.09 | 0.06 | -0.02 | sell |
| STIFEL FINANCIAL CORP | 89,102 | 98,341 | +9,239 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 96,674 | 95,443 | -1,231 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 75,404 | 91,134 | +15,730 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 84,575 | 84,546 | -29 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 90,855 | 83,207 | -7,648 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 126,158 | 79,538 | -46,620 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 63,300 | 79,430 | +16,130 | 0.39 | 0.75 | +0.36 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,019 | 78,287 | +6,268 | 0.00 | 0.00 | +0.00 | buy |