| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 2,127,467 | 4,255,047 | +2,127,580 | 0.05 | 0.14 | +0.10 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,432,440 | 3,311,963 | +1,879,523 | 0.02 | 0.08 | +0.06 | buy |
| MPM BioImpact LLC | 0 | 1,375,674 | +1,375,674 | 0.00 | 3.46 | +3.46 | buy |
| Nuveen, LLC | 266,043 | 1,475,798 | +1,209,755 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 1,092,110 | 2,012,110 | +920,000 | 0.71 | 1.65 | +0.95 | buy |
| Bank of New York Mellon Corp | 237,101 | 1,052,335 | +815,234 | 0.00 | 0.00 | +0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 638,000 | +638,000 | 0.00 | 2.17 | +2.17 | buy |
| JANE STREET GROUP, LLC | 167,493 | 738,266 | +570,773 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 644,542 | 1,077,585 | +433,043 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 3,442,752 | 3,853,549 | +410,797 | 0.00 | 0.00 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,100,000 | 2,500,000 | +400,000 | 3.80 | 6.03 | +2.23 | buy |
| MORGAN STANLEY | 849,236 | 1,199,296 | +350,060 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 333,733 | +333,733 | 0.00 | 1.04 | +1.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 230,577 | 558,076 | +327,499 | 0.00 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 256,488 | +256,488 | 0.00 | 0.34 | +0.34 | buy |
| Candriam S.C.A. | 675,085 | 925,332 | +250,247 | 0.04 | 0.07 | +0.04 | buy |
| UBS Group AG | 1,435,415 | 1,674,513 | +239,098 | 0.00 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 229,600 | +229,600 | 0.00 | 0.00 | +0.00 | buy |
| SECTOR GAMMA AS | 0 | 210,814 | +210,814 | 0.00 | 0.80 | +0.80 | buy |
| Palo Alto Investors LP | 444,367 | 654,930 | +210,563 | 0.89 | 1.86 | +0.98 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 178,289 | 341,194 | +162,905 | 0.02 | 0.05 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 556,971 | 712,659 | +155,688 | 0.01 | 0.02 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 155,316 | +155,316 | 0.00 | 0.01 | +0.01 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 128,845 | 261,933 | +133,088 | 0.04 | 0.10 | +0.06 | buy |
| Velan Capital Investment Management LP | 0 | 130,000 | +130,000 | 0.00 | 1.88 | +1.88 | buy |
| Ensign Peak Advisors, Inc | 689,064 | 809,064 | +120,000 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 5,033,934 | 5,138,617 | +104,683 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 499,903 | 599,871 | +99,968 | 0.00 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 28,227 | 124,575 | +96,348 | 0.00 | 0.03 | +0.02 | buy |
| Knott David M Jr | 352,778 | 428,000 | +75,222 | 1.50 | 2.76 | +1.26 | buy |
| ExodusPoint Capital Management, LP | 0 | 72,464 | +72,464 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 226,015 | 297,658 | +71,643 | 0.02 | 0.04 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 176,030 | 246,779 | +70,749 | 0.02 | 0.05 | +0.04 | buy |
| Aberdeen Group plc | 303,426 | 372,792 | +69,366 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 402,964 | 463,708 | +60,744 | 0.77 | 1.03 | +0.26 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 55,214 | +55,214 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 0 | 48,246 | +48,246 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 45,426 | +45,426 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 43,809 | +43,809 | 0.00 | 0.03 | +0.03 | buy |
| IEQ CAPITAL, LLC | 13,160 | 55,204 | +42,044 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,049,350 | 2,091,331 | +41,981 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 20,947 | 59,341 | +38,394 | 0.02 | 0.06 | +0.04 | buy |
| Quadrature Capital Ltd | 0 | 32,360 | +32,360 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 2,359,677 | 2,390,561 | +30,884 | 0.01 | 0.01 | +0.00 | buy |
| Scientech Research LLC | 0 | 30,875 | +30,875 | 0.00 | 0.17 | +0.17 | buy |
| Cinctive Capital Management LP | 0 | 30,440 | +30,440 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 13,554 | 43,448 | +29,894 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 105,157 | 133,091 | +27,934 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 26,774 | +26,774 | 0.00 | 0.00 | +0.00 | buy |
| Post Resch Tallon Group Inc. | 0 | 25,800 | +25,800 | 0.00 | 0.35 | +0.35 | buy |
| NEOS Investment Management LLC | 86,301 | 110,066 | +23,765 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 86,301 | 110,066 | +23,765 | 0.21 | 0.14 | -0.07 | buy |
| Mariner, LLC | 0 | 23,440 | +23,440 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 837,700 | 860,500 | +22,800 | 0.01 | 0.02 | +0.01 | buy |
| WINTON GROUP Ltd | 0 | 22,521 | +22,521 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 32,185 | 54,698 | +22,513 | 0.01 | 0.03 | +0.02 | buy |
| Concentric Capital Strategies, LP | 0 | 21,944 | +21,944 | 0.00 | 0.02 | +0.02 | buy |
| Bridgefront Capital, LLC | 0 | 21,848 | +21,848 | 0.00 | 0.10 | +0.10 | buy |
| HRT FINANCIAL LP | 127,111 | 148,139 | +21,028 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 11,959 | 30,393 | +18,434 | 0.00 | 0.02 | +0.02 | buy |
| HighTower Advisors, LLC | 0 | 17,423 | +17,423 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 18,363 | 35,656 | +17,293 | 0.03 | 0.09 | +0.06 | buy |
| SECTORAL ASSET MANAGEMENT INC | 63,300 | 79,430 | +16,130 | 0.39 | 0.75 | +0.36 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 16,107 | +16,107 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 126,045 | 141,822 | +15,777 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 75,404 | 91,134 | +15,730 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 15,200 | +15,200 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 12,885 | +12,885 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 4,327 | 16,791 | +12,464 | 0.00 | 0.02 | +0.01 | buy |
| CWM, LLC | 8,761 | 21,175 | +12,414 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 10,906 | +10,906 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 0 | 10,110 | +10,110 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 89,102 | 98,341 | +9,239 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 117,649 | 126,649 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 64,771 | 72,470 | +7,699 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 13,882 | 20,878 | +6,996 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 712,310 | 719,034 | +6,724 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,019 | 78,287 | +6,268 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 770,451 | 776,686 | +6,235 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 17,872 | 23,968 | +6,096 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 8,480 | 13,240 | +4,760 | 0.00 | 0.01 | +0.00 | buy |
| Arax Advisory Partners | 207 | 4,897 | +4,690 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 26,639 | 30,817 | +4,178 | 0.01 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 34,085 | 38,226 | +4,141 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,471 | +3,471 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 25,049 | 28,505 | +3,456 | 0.01 | 0.01 | -0.01 | buy |
| RHUMBLINE ADVISERS | 128,732 | 131,669 | +2,937 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 15,444 | 17,970 | +2,526 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,138 | +2,138 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 1,000 | 2,922 | +1,922 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,813 | 10,664 | +1,851 | 0.03 | 0.05 | +0.02 | buy |
| MARSHALL WACE, LLP | 232,123 | 233,973 | +1,850 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,692 | +1,692 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 122,163 | 123,404 | +1,241 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 12 | 719 | +707 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 688 | +688 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 14 | 613 | +599 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 240 | 745 | +505 | 0.00 | 0.00 | +0.00 | buy |
| C M BIDWELL & ASSOCIATES LTD | 0 | 308 | +308 | 0.00 | 0.00 | +0.00 | buy |