| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 3,600,000 | 5,660,000 | +2,060,000 | 8.69 | 13.84 | +5.15 | buy |
| Avoro Capital Advisors LLC | 2,555,555 | 4,222,222 | +1,666,667 | 0.58 | 1.26 | +0.68 | buy |
| T. Rowe Price Investment Management, Inc. | 1,066,548 | 2,711,253 | +1,644,705 | 0.01 | 0.04 | +0.03 | buy |
| Woodline Partners LP | 34,067 | 1,544,216 | +1,510,149 | 0.01 | 0.36 | +0.36 | buy |
| Avidity Partners Management LP | 2,821,000 | 3,950,000 | +1,129,000 | 1.65 | 3.26 | +1.62 | buy |
| Eversept Partners, LP | 2,596,245 | 3,383,244 | +786,999 | 3.19 | 6.42 | +3.23 | buy |
| Candriam S.C.A. | 240,010 | 1,021,032 | +781,022 | 0.02 | 0.15 | +0.13 | buy |
| Parkman Healthcare Partners LLC | 212,448 | 738,589 | +526,141 | 0.57 | 2.26 | +1.69 | buy |
| ORBIMED ADVISORS LLC | 1,284,000 | 1,749,000 | +465,000 | 0.40 | 0.76 | +0.36 | buy |
| Soleus Capital Management, L.P. | 119,500 | 514,000 | +394,500 | 0.17 | 1.23 | +1.06 | buy |
| DAFNA Capital Management LLC | 458,373 | 742,574 | +284,201 | 2.07 | 3.85 | +1.77 | buy |
| ExodusPoint Capital Management, LP | 155,714 | 353,252 | +197,538 | 0.03 | 0.10 | 0.00 | buy |
| Sofinnova Investments, Inc. | 941,817 | 1,075,786 | +133,969 | 0.86 | 1.30 | +0.44 | buy |
| Nantahala Capital Management, LLC | 240,031 | 365,259 | +125,228 | 0.30 | 0.47 | +0.17 | buy |
| Rafferty Asset Management, LLC | 284,124 | 403,381 | +119,257 | 0.02 | 0.04 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 431,565 | 535,938 | +104,373 | 0.02 | 0.03 | 0.00 | buy |
| AXIOM INVESTORS LLC /DE | 10,820 | 86,175 | +75,355 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 456,219 | 528,157 | +71,938 | 0.31 | 0.46 | 0.00 | buy |
| PROFUND ADVISORS LLC | 48,042 | 65,182 | +17,140 | 0.04 | 0.06 | 0.00 | buy |
| E Fund Management Co., Ltd. | 14,594 | 21,580 | +6,986 | 0.02 | 0.03 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 1,782 | 8,058 | +6,276 | 0.01 | 0.03 | +0.03 | buy |
| Mesirow Financial Investment Management, Inc. | 12,283 | 16,024 | +3,741 | 0.78 | 0.01 | -0.76 | buy |
| VIRTUS ADVISERS, LLC | 4,532 | 4,657 | +125 | 0.04 | 0.06 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 773,061 | 772,964 | -97 | 2.04 | 2.69 | +0.64 | sell |
| Simplify Asset Management Inc. | 12,665 | 11,801 | -864 | 0.03 | 0.04 | +0.01 | sell |
| ALPS ADVISORS INC | 51,236 | 48,126 | -3,110 | 0.01 | 0.01 | +0.00 | sell |
| Inspire Investing, LLC | 21,095 | 17,780 | -3,315 | 0.04 | 0.04 | +0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 219,974 | 196,033 | -23,941 | 0.10 | 0.13 | +0.03 | sell |
| BIT Capital GmbH | 37,300 | 8,054 | -29,246 | 0.06 | 0.02 | -0.05 | sell |
| Crestline Management, LP | 134,464 | 100,649 | -33,815 | 0.23 | 0.19 | -0.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 900,000 | -100,000 | 0.03 | 0.04 | +0.01 | sell |
| TWINBEECH CAPITAL LP | 188,110 | 83,456 | -104,654 | 0.05 | 0.03 | -0.02 | sell |
| Saturn V Capital Management LP | 807,969 | 518,799 | -289,170 | 4.91 | 4.29 | -0.62 | sell |
| PFM Health Sciences, LP | 2,715,235 | 595,523 | -2,119,712 | 1.86 | 0.77 | -1.09 | sell |
| JENNISON ASSOCIATES LLC | 2,347,673 | 50,780 | -2,296,893 | 0.03 | 0.00 | -0.03 | sell |