| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 3,600,000 | 5,660,000 | +2,060,000 | 8.69 | 13.84 | +5.15 | buy |
| BVF INC/IL | 0 | 1,875,000 | +1,875,000 | 0.00 | 1.01 | +1.01 | buy |
| Avoro Capital Advisors LLC | 2,555,555 | 4,222,222 | +1,666,667 | 0.58 | 1.26 | +0.68 | buy |
| T. Rowe Price Investment Management, Inc. | 1,066,548 | 2,711,253 | +1,644,705 | 0.01 | 0.04 | +0.03 | buy |
| Woodline Partners LP | 34,067 | 1,544,216 | +1,510,149 | 0.01 | 0.36 | +0.36 | buy |
| MARSHALL WACE, LLP | 603,962 | 2,101,911 | +1,497,949 | 0.02 | 0.09 | +0.07 | buy |
| STATE STREET CORP | 3,600,648 | 5,016,224 | +1,415,576 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 1,352,905 | +1,352,905 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 0 | 1,175,000 | +1,175,000 | 0.00 | 1.22 | +1.22 | buy |
| Avidity Partners Management LP | 2,821,000 | 3,950,000 | +1,129,000 | 1.65 | 3.26 | +1.62 | buy |
| MORGAN STANLEY | 550,029 | 1,664,306 | +1,114,277 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 2,596,245 | 3,383,244 | +786,999 | 4.19 | 7.17 | +2.98 | buy |
| Candriam S.C.A. | 240,010 | 1,021,032 | +781,022 | 0.02 | 0.15 | +0.13 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 780,000 | +780,000 | 0.00 | 0.06 | +0.06 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 746,293 | +746,293 | 0.00 | 3.07 | +3.07 | buy |
| Point72 Asset Management, L.P. | 2,094,201 | 2,834,499 | +740,298 | 0.10 | 0.19 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 259,858 | 984,258 | +724,400 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,617,302 | 4,335,353 | +718,051 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 212,448 | 738,589 | +526,141 | 0.57 | 2.26 | +1.69 | buy |
| MILLENNIUM MANAGEMENT LLC | 439,770 | 942,642 | +502,872 | 0.01 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 1,284,000 | 1,749,000 | +465,000 | 0.40 | 0.76 | +0.36 | buy |
| Soleus Capital Management, L.P. | 119,500 | 514,000 | +394,500 | 0.17 | 1.23 | +1.06 | buy |
| Granahan Investment Management, LLC | 0 | 320,911 | +320,911 | 0.00 | 0.23 | +0.23 | buy |
| DAFNA Capital Management LLC | 458,373 | 742,574 | +284,201 | 2.07 | 3.85 | +1.77 | buy |
| Zimmer Partners, LP | 0 | 275,100 | +275,100 | 0.00 | 0.22 | +0.22 | buy |
| Schonfeld Strategic Advisors LLC | 218,413 | 471,475 | +253,062 | 0.03 | 0.08 | +0.05 | buy |
| UBS Group AG | 75,357 | 290,801 | +215,444 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 155,714 | 353,252 | +197,538 | 0.03 | 0.09 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,360,920 | 1,535,055 | +174,135 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.32 | +0.32 | buy |
| Trexquant Investment LP | 0 | 143,514 | +143,514 | 0.00 | 0.07 | +0.07 | buy |
| Sofinnova Investments, Inc. | 941,817 | 1,075,786 | +133,969 | 0.95 | 1.30 | +0.35 | buy |
| Verition Fund Management LLC | 15,000 | 143,266 | +128,266 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Capital LLC | 0 | 127,932 | +127,932 | 0.00 | 0.04 | +0.04 | buy |
| Nantahala Capital Management, LLC | 240,031 | 365,259 | +125,228 | 0.44 | 0.79 | +0.35 | buy |
| Rafferty Asset Management, LLC | 284,124 | 403,381 | +119,257 | 0.02 | 0.04 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 48,889 | 166,033 | +117,144 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 431,565 | 535,938 | +104,373 | 0.02 | 0.03 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 95,949 | +95,949 | 0.00 | 0.07 | +0.07 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 92,060 | +92,060 | 0.00 | 0.86 | +0.86 | buy |
| TWO SIGMA ADVISERS, LP | 67,052 | 151,452 | +84,400 | 0.00 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 91,499 | 174,144 | +82,645 | 0.01 | 0.02 | +0.01 | buy |
| AXIOM INVESTORS LLC /DE | 10,820 | 86,175 | +75,355 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 456,219 | 528,157 | +71,938 | 0.31 | 0.46 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 506,467 | 577,022 | +70,555 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 67,100 | +67,100 | 0.00 | 0.04 | +0.04 | buy |
| SIMPLEX TRADING, LLC | 0 | 64,030 | +64,030 | 0.00 | 0.04 | +0.04 | buy |
| Lighthouse Investment Partners, LLC | 0 | 52,199 | +52,199 | 0.00 | 0.08 | +0.08 | buy |
| JPMORGAN CHASE & CO | 729,098 | 780,930 | +51,832 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 48,718 | +48,718 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 117,999 | 162,905 | +44,906 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 635,525 | 678,105 | +42,580 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 120,232 | 162,406 | +42,174 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.12 | +0.12 | buy |
| TUDOR INVESTMENT CORP ET AL | 29,939 | 68,981 | +39,042 | 0.01 | 0.02 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 31,000 | +31,000 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 30,760 | +30,760 | 0.00 | 0.00 | +0.00 | buy |
| Parallax Volatility Advisers, L.P. | 13,788 | 41,985 | +28,197 | 0.01 | 0.02 | +0.02 | buy |
| State of New Jersey Common Pension Fund D | 133,034 | 159,803 | +26,769 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 24,659 | +24,659 | 0.00 | 0.04 | +0.04 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 54,456 | 78,758 | +24,302 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 29,120 | 52,035 | +22,915 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 390,538 | 411,965 | +21,427 | 0.02 | 0.03 | +0.01 | buy |
| Swiss National Bank | 121,000 | 142,400 | +21,400 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,841 | 29,169 | +19,328 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 48,042 | 65,182 | +17,140 | 0.04 | 0.06 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 148,524 | 165,018 | +16,494 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 76,663 | 93,067 | +16,404 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 15,116 | +15,116 | 0.00 | 0.03 | +0.03 | buy |
| Graham Capital Management, L.P. | 0 | 14,936 | +14,936 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,192 | 75,407 | +12,215 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 43,120 | 55,194 | +12,074 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,948 | +11,948 | 0.00 | 0.02 | +0.02 | buy |
| MACQUARIE GROUP LTD | 232,466 | 244,090 | +11,624 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,572 | 35,902 | +11,330 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 11,329 | +11,329 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 10,895 | +10,895 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 11,479 | 19,362 | +7,883 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 14,594 | 21,580 | +6,986 | 0.02 | 0.03 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 499,521 | 506,009 | +6,488 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,782 | 8,058 | +6,276 | 0.01 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 50,177 | 55,122 | +4,945 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 42,192 | 46,897 | +4,705 | 0.00 | 0.00 | +0.00 | buy |
| Mesirow Financial Investment Management, Inc. | 12,283 | 16,024 | +3,741 | 0.78 | 0.01 | -0.76 | buy |
| SIGNATUREFD, LLC | 126 | 3,748 | +3,622 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 227,504 | 230,858 | +3,354 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 36,135 | 39,472 | +3,337 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 106,140 | 109,303 | +3,163 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 4,647 | 7,730 | +3,083 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 13,102 | 15,513 | +2,411 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 6,028 | 8,076 | +2,048 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,410 | 26,267 | +1,857 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 945 | 2,441 | +1,496 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 327 | 1,685 | +1,358 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,964 | 14,126 | +1,162 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 978 | +978 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 150 | 986 | +836 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 15,676 | 16,511 | +835 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 750 | +750 | 0.00 | 0.01 | +0.01 | buy |