| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,239,050 | 9,033,949 | +794,899 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 5,842,925 | 8,520,000 | +2,677,075 | 8.72 | 7.43 | -1.29 | buy |
| GOLDMAN SACHS GROUP INC | 1,612,052 | 5,950,537 | +4,338,485 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 887,145 | 5,312,822 | +4,425,677 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,886,974 | 4,881,968 | -5,006 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,985,976 | 4,234,455 | -751,521 | 0.02 | 0.01 | -0.01 | sell |
| STATE STREET CORP | 3,770,826 | 3,917,516 | +146,690 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 1,731,191 | 2,872,601 | +1,141,410 | 9.99 | 9.52 | -0.47 | buy |
| Soleus Capital Management, L.P. | 1,090,984 | 2,492,000 | +1,401,016 | 1.75 | 2.49 | +0.75 | buy |
| Avoro Capital Advisors LLC | 3,888,437 | 2,275,000 | -1,613,437 | 1.09 | 0.43 | -0.67 | sell |
| Assenagon Asset Management S.A. | 466,028 | 2,064,456 | +1,598,428 | 0.02 | 0.05 | +0.03 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,000,000 | 2,000,000 | +1,000,000 | 2.83 | 4.52 | +1.69 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,977,082 | 1,973,116 | -3,966 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 2,778,267 | 1,915,736 | -862,531 | 0.19 | 0.07 | -0.12 | sell |
| Woodline Partners LP | 1,896,032 | 1,891,803 | -4,229 | 0.31 | 0.17 | -0.14 | sell |
| FRANKLIN RESOURCES INC | 1,763,277 | 1,766,859 | +3,582 | 0.01 | 0.01 | -0.00 | buy |
| Avidity Partners Management LP | 2,455,000 | 1,500,000 | -955,000 | 2.41 | 1.98 | -0.43 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,034,846 | 1,381,241 | +346,395 | 3.26 | 3.37 | +0.11 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 378,746 | 1,230,400 | +851,654 | 1.64 | 3.64 | +1.99 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 786,990 | 1,178,062 | +391,072 | 0.26 | 0.28 | +0.02 | buy |
| CITADEL ADVISORS LLC | 34,020 | 1,089,803 | +1,055,783 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 146,438 | 1,028,821 | +882,383 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 1,025,000 | 1,025,000 | 0 | 7.56 | 4.81 | -2.75 | hold |
| BNP Paribas Asset Management Holding S.A. | 787,785 | 1,022,537 | +234,752 | 0.04 | 0.03 | -0.00 | buy |
| Saturn V Capital Management LP | 501,978 | 988,528 | +486,550 | 3.45 | 5.12 | +1.66 | buy |
| Granahan Investment Management, LLC | 664,765 | 905,322 | +240,557 | 0.50 | 0.50 | -0.00 | buy |
| Octagon Capital Advisors LP | 0 | 904,000 | +904,000 | 0.00 | 2.03 | +2.03 | buy |
| JPMORGAN CHASE & CO | 627,679 | 897,317 | +269,638 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 737,606 | 792,750 | +55,144 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 474,998 | 785,632 | +310,634 | 0.25 | 0.24 | -0.00 | buy |
| Qube Research & Technologies Ltd | 683,202 | 724,416 | +41,214 | 0.02 | 0.02 | -0.01 | buy |
| Crestline Management, LP | 428,538 | 713,205 | +284,667 | 0.47 | 0.33 | -0.14 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 695,947 | 704,823 | +8,876 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 680,965 | +680,965 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 886,494 | 669,823 | -216,671 | 0.04 | 0.02 | -0.02 | sell |
| Sofinnova Investments, Inc. | 786,999 | 658,627 | -128,372 | 1.25 | 0.64 | -0.62 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 817,600 | 621,840 | -195,760 | 0.03 | 0.01 | -0.01 | sell |
| Prosight Management, LP | 554,103 | 620,000 | +65,897 | 2.70 | 2.30 | -0.41 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,119,963 | 586,810 | -533,153 | 0.02 | 0.01 | -0.01 | sell |
| Nantahala Capital Management, LLC | 453,232 | 560,532 | +107,300 | 0.73 | 0.52 | -0.22 | buy |
| Candriam S.C.A. | 998,619 | 547,165 | -451,454 | 0.11 | 0.04 | -0.07 | sell |
| DAFNA Capital Management LLC | 526,702 | 542,002 | +15,300 | 2.40 | 1.82 | -0.57 | buy |
| TWO SIGMA ADVISERS, LP | 669,352 | 535,952 | -133,400 | 0.03 | 0.02 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 508,283 | 526,973 | +18,690 | 1.25 | 0.93 | -0.32 | buy |
| Polar Capital Holdings Plc | 500,000 | 500,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Casdin Capital, LLC | 475,000 | 475,000 | 0 | 0.61 | 0.42 | -0.19 | hold |
| Trexquant Investment LP | 33,433 | 471,292 | +437,859 | 0.01 | 0.07 | +0.06 | buy |
| First Turn Management, LLC | 1,187,165 | 441,587 | -745,578 | 3.62 | 1.05 | -2.57 | sell |
| Palo Alto Investors LP | 405,193 | 405,193 | 0 | 1.01 | 0.83 | -0.18 | hold |
| Altium Capital Management LLC | 0 | 370,000 | +370,000 | 0.00 | 1.52 | +1.52 | buy |
| Walleye Capital LLC | 38,165 | 364,750 | +326,585 | 0.01 | 0.05 | +0.04 | buy |
| Cubist Systematic Strategies, LLC | 0 | 358,071 | +358,071 | 0.00 | 0.08 | +0.08 | buy |
| TWINBEECH CAPITAL LP | 198,579 | 355,900 | +157,321 | 0.07 | 0.08 | +0.01 | buy |
| Eversept Partners, LP | 4,105,313 | 343,400 | -3,761,913 | 6.06 | 0.47 | -5.59 | sell |
| Hudson Bay Capital Management LP | 425,000 | 336,000 | -89,000 | 0.06 | 0.03 | -0.03 | sell |
| DIMENSIONAL FUND ADVISORS LP | 47,723 | 331,300 | +283,577 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 318,900 | +318,900 | 0.00 | 3.17 | +3.17 | buy |
| Ensign Peak Advisors, Inc | 361,825 | 267,949 | -93,876 | 0.01 | 0.01 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 21,099 | 259,245 | +238,146 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 252,000 | +252,000 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 757,307 | 245,508 | -511,799 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 259,500 | 232,000 | -27,500 | 0.41 | 0.32 | -0.09 | sell |
| Bank of New York Mellon Corp | 221,502 | 224,261 | +2,759 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 20,326 | 214,667 | +194,341 | 0.04 | 0.12 | +0.08 | buy |
| PFM Health Sciences, LP | 423,910 | 206,871 | -217,039 | 0.47 | 0.21 | -0.26 | sell |
| BARCLAYS PLC | 187,629 | 196,051 | +8,422 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 352,358 | 184,117 | -168,241 | 0.01 | 0.00 | -0.01 | sell |
| Propel Bio Management, LLC | 133,259 | 183,259 | +50,000 | 1.49 | 2.41 | +0.92 | buy |
| MACQUARIE GROUP LTD | 243,352 | 180,000 | -63,352 | 0.01 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 171,522 | 178,165 | +6,643 | 0.01 | 0.01 | -0.00 | buy |
| Jump Financial, LLC | 96,191 | 173,890 | +77,699 | 0.04 | 0.05 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 137,447 | 170,100 | +32,653 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 149,400 | 149,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 318,394 | 148,568 | -169,826 | 0.06 | 0.02 | -0.04 | sell |
| Engineers Gate Manager LP | 59,411 | 147,673 | +88,262 | 0.02 | 0.03 | +0.01 | buy |
| Simplify Asset Management Inc. | 122,185 | 147,641 | +25,456 | 0.16 | 0.14 | -0.03 | buy |
| CITIGROUP INC | 60,936 | 144,452 | +83,516 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 94,772 | 133,111 | +38,339 | 0.01 | 0.01 | -0.00 | buy |
| Knott David M Jr | 122,144 | 128,000 | +5,856 | 0.83 | 0.61 | -0.21 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,706 | 127,557 | -41,149 | 0.01 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 121,539 | +121,539 | 0.00 | 0.00 | +0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 116,812 | 115,087 | -1,725 | 0.03 | 0.02 | -0.01 | sell |
| RHUMBLINE ADVISERS | 114,459 | 113,449 | -1,010 | 0.00 | 0.00 | -0.00 | sell |
| Yelin Lapidot Holdings Management Ltd. | 108,377 | 108,377 | 0 | 0.34 | 0.25 | -0.09 | hold |
| HRT FINANCIAL LP | 53,426 | 104,880 | +51,454 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.09 | +0.09 | buy |
| Aberdeen Group plc | 0 | 99,340 | +99,340 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 89,481 | 90,232 | +751 | 0.04 | 0.03 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 66,270 | 89,904 | +23,634 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 86,225 | +86,225 | 0.00 | 0.10 | +0.10 | buy |
| ALLIANCEBERNSTEIN L.P. | 85,250 | 85,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 49,248 | 85,201 | +35,953 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 84,998 | +84,998 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 81,302 | 83,297 | +1,995 | 0.10 | 0.07 | -0.02 | buy |
| Legal & General Group Plc | 80,938 | 80,862 | -76 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 79,071 | +79,071 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 18,070 | 76,914 | +58,844 | 0.04 | 0.12 | +0.08 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,761 | 72,019 | -742 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 70,000 | 70,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 367,177 | 69,586 | -297,591 | 0.02 | 0.00 | -0.02 | sell |