| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 5,842,925 | 8,520,000 | +2,677,075 | 8.72 | 7.43 | -1.29 | buy |
| Soleus Capital Management, L.P. | 1,090,984 | 2,492,000 | +1,401,016 | 1.75 | 2.49 | +0.75 | buy |
| STEMPOINT CAPITAL LP | 1,731,191 | 2,872,601 | +1,141,410 | 9.99 | 9.52 | -0.47 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,000,000 | 2,000,000 | +1,000,000 | 2.83 | 4.52 | +1.69 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 378,746 | 1,230,400 | +851,654 | 1.64 | 3.64 | +1.99 | buy |
| Saturn V Capital Management LP | 501,978 | 988,528 | +486,550 | 3.45 | 5.12 | +1.66 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 786,990 | 1,178,062 | +391,072 | 0.26 | 0.28 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,034,846 | 1,381,241 | +346,395 | 3.17 | 3.30 | +0.13 | buy |
| ALGERT GLOBAL LLC | 474,998 | 785,632 | +310,634 | 0.25 | 0.25 | 0.00 | buy |
| Crestline Management, LP | 428,538 | 713,205 | +284,667 | 0.43 | 0.31 | -0.12 | buy |
| Granahan Investment Management, LLC | 664,765 | 905,322 | +240,557 | 0.50 | 0.50 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 787,785 | 1,022,537 | +234,752 | 0.04 | 0.03 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 886,494 | 669,823 | +216,671 | 0.04 | 0.02 | 0.00 | sell |
| ExodusPoint Capital Management, LP | 318,394 | 148,568 | +169,826 | 0.06 | 0.02 | 0.00 | sell |
| TWINBEECH CAPITAL LP | 198,579 | 355,900 | +157,321 | 0.07 | 0.08 | +0.01 | buy |
| Nantahala Capital Management, LLC | 453,232 | 560,532 | +107,300 | 0.44 | 0.32 | -0.12 | buy |
| Prosight Management, LP | 554,103 | 620,000 | +65,897 | 2.62 | 2.27 | -0.36 | buy |
| Nebula Research & Development LLC | 18,070 | 76,914 | +58,844 | 0.04 | 0.12 | +0.08 | buy |
| Propel Bio Management, LLC | 133,259 | 183,259 | +50,000 | 1.49 | 2.41 | +0.92 | buy |
| Simplify Asset Management Inc. | 122,185 | 147,641 | +25,456 | 0.16 | 0.14 | -0.03 | buy |
| Parkman Healthcare Partners LLC | 508,283 | 526,973 | +18,690 | 1.25 | 0.93 | -0.32 | buy |
| DAFNA Capital Management LLC | 526,702 | 542,002 | +15,300 | 2.40 | 1.82 | -0.57 | buy |
| Inspire Investing, LLC | 21,308 | 30,792 | +9,484 | 0.04 | 0.05 | +0.00 | buy |
| Lion Point Capital, LP | 46,200 | 55,000 | +8,800 | 1.98 | 3.81 | +1.83 | buy |
| Rafferty Asset Management, LLC | 171,522 | 178,165 | +6,643 | 0.01 | 0.01 | -0.00 | buy |
| Knott David M Jr | 122,144 | 128,000 | +5,856 | 0.83 | 0.61 | -0.21 | buy |
| AlphaQuest LLC | 17,858 | 23,623 | +5,765 | 0.03 | 0.04 | 0.00 | buy |
| DnB Asset Management AS | 17,362 | 22,943 | +5,581 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 81,302 | 83,297 | +1,995 | 0.10 | 0.07 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,367 | 18,099 | +1,732 | 0.03 | 0.02 | -0.01 | buy |
| E Fund Management Co., Ltd. | 11,020 | 12,603 | +1,583 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,451 | 5,278 | +827 | 0.04 | 0.03 | -0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 89,481 | 90,232 | +751 | 0.14 | 0.10 | 0.00 | buy |
| Truvestments Capital LLC | 517 | 915 | +398 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 34,161 | 34,548 | +387 | 0.03 | 0.02 | 0.00 | buy |
| Mesirow Financial Investment Management, Inc. | 10,126 | 10,242 | +116 | 0.00 | 0.00 | -0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 116,812 | 115,087 | -1,725 | 0.03 | 0.02 | -0.01 | sell |
| Woodline Partners LP | 1,896,032 | 1,891,803 | -4,229 | 0.31 | 0.17 | -0.14 | sell |
| Clearline Capital LP | 42,195 | 34,177 | -8,018 | 0.03 | 0.06 | +0.03 | sell |
| Brevan Howard Capital Management LP | 22,685 | 14,071 | -8,614 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 29,956 | 16,355 | -13,601 | 0.13 | 0.04 | -0.09 | sell |
| Rhenman & Partners Asset Management AB | 259,500 | 232,000 | -27,500 | 0.41 | 0.32 | -0.09 | sell |
| AXIOM INVESTORS LLC /DE | 115,642 | 53,224 | -62,418 | 0.02 | 0.01 | -0.01 | sell |
| Hudson Bay Capital Management LP | 425,000 | 336,000 | -89,000 | 0.03 | 0.02 | -0.02 | sell |
| Sofinnova Investments, Inc. | 786,999 | 658,627 | -128,372 | 1.20 | 0.63 | -0.57 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 817,600 | 621,840 | -195,760 | 0.03 | 0.01 | -0.01 | sell |
| PFM Health Sciences, LP | 423,910 | 206,871 | -217,039 | 0.46 | 0.17 | -0.29 | sell |
| Candriam S.C.A. | 970,106 | 547,165 | -422,941 | 0.12 | 0.04 | -0.08 | sell |
| First Turn Management, LLC | 1,187,165 | 441,587 | -745,578 | 3.62 | 1.05 | -2.57 | sell |
| Avidity Partners Management LP | 2,455,000 | 1,500,000 | -955,000 | 2.41 | 1.98 | -0.43 | sell |
| Avoro Capital Advisors LLC | 3,888,437 | 2,275,000 | -1,613,437 | 1.09 | 0.43 | -0.67 | sell |
| Eversept Partners, LP | 4,105,313 | 343,400 | -3,761,913 | 5.41 | 0.40 | -5.01 | sell |