| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,625,244 | 8,239,002 | -386,242 | 0.00 | 0.00 | +0.00 | sell |
| Kynam Capital Management, LP | 8,520,000 | 8,050,959 | -469,041 | 9.76 | 11.01 | +1.25 | sell |
| VANGUARD GROUP INC | 5,138,617 | 6,230,334 | +1,091,717 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 5,486,434 | 5,695,375 | +208,941 | 0.01 | 0.02 | +0.00 | buy |
| Point72 Asset Management, L.P. | 4,255,047 | 4,882,053 | +627,006 | 0.14 | 0.16 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 3,697,753 | 4,710,746 | +1,012,993 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,853,549 | 4,596,552 | +743,003 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 3,467,314 | 3,314,408 | -152,906 | 4.09 | 3.90 | -0.18 | sell |
| FRANKLIN RESOURCES INC | 2,390,561 | 2,421,666 | +31,105 | 0.01 | 0.01 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,500,000 | 2,350,000 | -150,000 | 6.03 | 7.56 | +1.53 | sell |
| Hood River Capital Management LLC | 0 | 2,316,553 | +2,316,553 | 0.00 | 0.53 | +0.53 | buy |
| Soleus Capital Management, L.P. | 2,012,110 | 2,247,110 | +235,000 | 1.65 | 2.00 | +0.35 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,091,331 | 2,090,932 | -399 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 809,064 | 1,598,544 | +789,480 | 0.02 | 0.06 | +0.04 | buy |
| Nuveen, LLC | 1,475,798 | 1,483,002 | +7,204 | 0.01 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,236,077 | 1,375,681 | +139,604 | 0.05 | 0.03 | -0.02 | buy |
| STEMPOINT CAPITAL LP | 1,366,205 | 1,339,379 | -26,826 | 4.24 | 4.83 | +0.59 | sell |
| MPM BioImpact LLC | 1,375,674 | 1,337,702 | -37,972 | 3.46 | 3.22 | -0.25 | sell |
| Aisling Capital Management LP | 1,316,806 | 1,316,806 | 0 | 4.44 | 5.78 | +1.34 | hold |
| Woodline Partners LP | 1,550,520 | 1,250,668 | -299,852 | 0.11 | 0.10 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 988,486 | 1,238,196 | +249,710 | 0.25 | 0.41 | +0.16 | buy |
| D. E. Shaw & Co., Inc. | 1,077,585 | 1,219,609 | +142,024 | 0.01 | 0.02 | +0.01 | buy |
| Catalio Capital Management, LP | 1,614,717 | 1,196,807 | -417,910 | 4.59 | 4.44 | -0.15 | sell |
| TWO SIGMA INVESTMENTS, LP | 712,659 | 1,146,936 | +434,277 | 0.02 | 0.04 | +0.02 | buy |
| Bank of New York Mellon Corp | 1,052,335 | 1,094,151 | +41,816 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,199,296 | 1,075,501 | -123,795 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 930,766 | 928,088 | -2,678 | 0.24 | 0.30 | +0.06 | sell |
| AQR CAPITAL MANAGEMENT LLC | 558,076 | 925,974 | +367,898 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 925,332 | 925,332 | 0 | 0.07 | 0.10 | +0.02 | hold |
| Palo Alto Investors LP | 654,930 | 794,507 | +139,577 | 1.86 | 2.32 | +0.46 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 387,716 | 762,563 | +374,847 | 1.41 | 3.35 | +1.93 | buy |
| JANE STREET GROUP, LLC | 738,266 | 748,920 | +10,654 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 776,686 | 728,921 | -47,765 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 719,034 | 727,424 | +8,390 | 0.00 | 0.00 | +0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 638,000 | 724,000 | +86,000 | 2.17 | 2.65 | +0.48 | buy |
| UBS Group AG | 1,674,513 | 716,219 | -958,294 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,644,844 | 688,137 | -956,707 | 0.04 | 0.02 | -0.02 | sell |
| Prosight Management, LP | 1,003,400 | 665,000 | -338,400 | 3.71 | 2.89 | -0.82 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 463,708 | 642,899 | +179,191 | 1.03 | 1.95 | +0.92 | buy |
| TWO SIGMA ADVISERS, LP | 383,052 | 632,752 | +249,700 | 0.01 | 0.03 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 846,899 | 574,023 | -272,876 | 1.43 | 1.15 | -0.28 | sell |
| ExodusPoint Capital Management, LP | 72,464 | 554,761 | +482,297 | 0.02 | 0.13 | +0.11 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 860,500 | 544,800 | -315,700 | 0.02 | 0.02 | +0.00 | sell |
| Brevan Howard Capital Management LP | 124,575 | 515,129 | +390,554 | 0.03 | 0.21 | +0.18 | buy |
| Rhenman & Partners Asset Management AB | 574,000 | 487,000 | -87,000 | 0.98 | 0.96 | -0.02 | sell |
| Knott David M Jr | 428,000 | 415,000 | -13,000 | 2.76 | 4.04 | +1.28 | sell |
| JPMORGAN CHASE & CO | 253,850 | 378,504 | +124,654 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 372,792 | 372,792 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Granahan Investment Management, LLC | 396,336 | 366,793 | -29,543 | 0.25 | 0.33 | +0.08 | sell |
| BARCLAYS PLC | 348,061 | 314,672 | -33,389 | 0.00 | 0.00 | +0.00 | sell |
| Pale Fire Capital SE | 0 | 284,460 | +284,460 | 0.00 | 0.77 | +0.77 | buy |
| AMERIPRISE FINANCIAL INC | 95,443 | 282,587 | +187,144 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 500,702 | 277,855 | -222,847 | 1.90 | 1.36 | -0.55 | sell |
| SECTOR GAMMA AS | 210,814 | 252,062 | +41,248 | 0.80 | 1.21 | +0.40 | buy |
| PFM Health Sciences, LP | 256,488 | 242,967 | -13,521 | 0.34 | 0.52 | +0.18 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 341,194 | 233,871 | -107,323 | 0.05 | 0.05 | -0.01 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 229,600 | 229,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.21 | +0.21 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 200,000 | 200,000 | 0 | 1.82 | 2.05 | +0.23 | hold |
| CITADEL ADVISORS LLC | 546,268 | 184,003 | -362,265 | 0.01 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 54,698 | 183,802 | +129,104 | 0.03 | 0.13 | +0.10 | buy |
| Hudson Bay Capital Management LP | 250,000 | 165,000 | -85,000 | 0.02 | 0.02 | -0.00 | sell |
| Jump Financial, LLC | 132,701 | 163,915 | +31,214 | 0.03 | 0.04 | +0.01 | buy |
| Rafferty Asset Management, LLC | 141,822 | 161,943 | +20,121 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 158,500 | 161,400 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 56,916 | 160,850 | +103,934 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 133,091 | 160,525 | +27,434 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 43,448 | 159,638 | +116,190 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 100,851 | 155,916 | +55,065 | 0.04 | 0.07 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 134,261 | 142,407 | +8,146 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 141,666 | +141,666 | 0.00 | 0.24 | +0.24 | buy |
| FMR LLC | 5,101 | 140,560 | +135,459 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 137,629 | +137,629 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 130,000 | 130,000 | 0 | 1.88 | 1.59 | -0.29 | hold |
| SG Americas Securities, LLC | 45,426 | 129,227 | +83,801 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 155,316 | 125,099 | -30,217 | 0.01 | 0.01 | -0.00 | sell |
| Voss Capital, LP | 0 | 125,000 | +125,000 | 0.00 | 0.14 | +0.14 | buy |
| RHUMBLINE ADVISERS | 131,669 | 118,799 | -12,870 | 0.00 | 0.00 | +0.00 | sell |
| Yelin Lapidot Holdings Management Ltd. | 108,377 | 108,377 | 0 | 0.35 | 0.46 | +0.11 | hold |
| NEOS Investment Management LLC | 110,066 | 101,553 | -8,513 | 0.01 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 110,066 | 100,053 | -10,013 | 0.14 | 0.16 | +0.02 | sell |
| IEQ CAPITAL, LLC | 55,204 | 99,876 | +44,672 | 0.00 | 0.01 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 0 | 97,802 | +97,802 | 0.00 | 0.29 | +0.29 | buy |
| ALLIANCEBERNSTEIN L.P. | 126,649 | 94,880 | -31,769 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 91,134 | 94,829 | +3,695 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 79,538 | 89,639 | +10,101 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 87,514 | +87,514 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 84,546 | 78,236 | -6,310 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,287 | 78,199 | -88 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 98,341 | 75,914 | -22,427 | 0.00 | 0.00 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 160,327 | 72,703 | -87,624 | 0.04 | 0.07 | +0.03 | sell |
| DEUTSCHE BANK AG\ | 72,470 | 66,608 | -5,862 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 55,214 | 65,280 | +10,066 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 79,430 | 61,200 | -18,230 | 0.75 | 1.03 | +0.28 | sell |
| PROFUND ADVISORS LLC | 30,817 | 60,038 | +29,221 | 0.02 | 0.04 | +0.02 | buy |
| Mariner, LLC | 23,440 | 54,987 | +31,547 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 28,505 | 54,715 | +26,210 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 83,207 | 53,582 | -29,625 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 44,294 | 52,900 | +8,606 | 0.03 | 0.08 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,046,456 | 51,937 | -994,519 | 0.01 | 0.00 | -0.01 | sell |