| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 387,716 | 762,563 | +374,847 | 1.26 | 3.10 | +1.84 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 860,500 | 544,800 | +315,700 | 0.02 | 0.02 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 988,486 | 1,238,196 | +249,710 | 0.25 | 0.41 | +0.16 | buy |
| Soleus Capital Management, L.P. | 2,012,110 | 2,247,110 | +235,000 | 1.65 | 2.00 | +0.35 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 463,708 | 642,899 | +179,191 | 1.03 | 1.95 | +0.92 | buy |
| Palo Alto Investors LP | 654,930 | 794,507 | +139,577 | 1.86 | 2.32 | +0.46 | buy |
| Hennion & Walsh Asset Management, Inc. | 54,698 | 183,802 | +129,104 | 0.03 | 0.13 | +0.10 | buy |
| APIS CAPITAL ADVISORS, LLC | 638,000 | 724,000 | +86,000 | 2.17 | 2.65 | +0.48 | buy |
| Y-Intercept (Hong Kong) Ltd | 100,851 | 155,916 | +55,065 | 0.04 | 0.08 | 0.00 | buy |
| SECTOR GAMMA AS | 210,814 | 252,062 | +41,248 | 0.80 | 1.21 | +0.40 | buy |
| PROFUND ADVISORS LLC | 30,817 | 60,038 | +29,221 | 0.02 | 0.04 | 0.00 | buy |
| Simplify Asset Management Inc. | 28,505 | 54,715 | +26,210 | 0.01 | 0.02 | +0.01 | buy |
| Quarry LP | 35,365 | 10,000 | +25,365 | 0.14 | 0.03 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 10,664 | 33,549 | +22,885 | 0.05 | 0.19 | +0.14 | buy |
| Rafferty Asset Management, LLC | 141,822 | 161,943 | +20,121 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 55,214 | 65,280 | +10,066 | 0.00 | 0.00 | 0.00 | buy |
| Clearline Capital LP | 34,177 | 43,413 | +9,236 | 0.02 | 0.04 | +0.02 | buy |
| TWINBEECH CAPITAL LP | 44,294 | 52,900 | +8,606 | 0.03 | 0.08 | +0.05 | buy |
| DnB Asset Management AS | 23,294 | 29,760 | +6,466 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 35,656 | 40,302 | +4,646 | 0.09 | 0.13 | +0.05 | buy |
| Pallas Capital Advisors LLC | 10,110 | 10,985 | +875 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,853 | 1,708 | -145 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 15,099 | 14,163 | -936 | 0.02 | 0.02 | +0.00 | sell |
| Bridgefront Capital, LLC | 21,848 | 19,752 | -2,096 | 0.10 | 0.10 | +0.01 | sell |
| Post Resch Tallon Group Inc. | 25,800 | 22,800 | -3,000 | 0.35 | 0.40 | +0.05 | sell |
| Inspire Investing, LLC | 28,833 | 22,142 | -6,691 | 0.04 | 0.04 | -0.00 | sell |
| WINTON GROUP Ltd | 22,521 | 14,574 | -7,947 | 0.01 | 0.01 | -0.00 | sell |
| NEOS Investment Management LLC | 110,066 | 101,553 | -8,513 | 0.01 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 110,066 | 100,053 | -10,013 | 0.14 | 0.16 | +0.02 | sell |
| Knott David M Jr | 428,000 | 415,000 | -13,000 | 2.76 | 4.04 | +1.28 | sell |
| PFM Health Sciences, LP | 256,488 | 242,967 | -13,521 | 0.30 | 0.51 | +0.21 | sell |
| SECTORAL ASSET MANAGEMENT INC | 79,430 | 61,200 | -18,230 | 0.75 | 1.03 | +0.28 | sell |
| Lion Point Capital, LP | 55,000 | 36,000 | -19,000 | 4.81 | 3.91 | -0.89 | sell |
| STEMPOINT CAPITAL LP | 1,366,205 | 1,339,379 | -26,826 | 4.24 | 4.83 | +0.59 | sell |
| Granahan Investment Management, LLC | 396,336 | 366,793 | -29,543 | 0.25 | 0.33 | +0.08 | sell |
| MPM BioImpact LLC | 1,375,674 | 1,337,702 | -37,972 | 3.46 | 3.22 | -0.25 | sell |
| SummitTX Capital, L.P. | 100,586 | 39,127 | -61,459 | 0.06 | 0.02 | -0.04 | sell |
| Rhenman & Partners Asset Management AB | 574,000 | 487,000 | -87,000 | 0.98 | 0.96 | -0.02 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,500,000 | 2,350,000 | -150,000 | 6.03 | 7.56 | +1.53 | sell |
| Eversept Partners, LP | 3,467,314 | 3,314,408 | -152,906 | 3.68 | 3.51 | -0.17 | sell |
| DAFNA Capital Management LLC | 500,702 | 277,855 | -222,847 | 1.90 | 1.36 | -0.55 | sell |
| Parkman Healthcare Partners LLC | 846,899 | 574,023 | -272,876 | 1.43 | 1.15 | -0.28 | sell |
| Prosight Management, LP | 1,003,400 | 665,000 | -338,400 | 3.60 | 2.89 | -0.71 | sell |
| Catalio Capital Management, LP | 1,614,717 | 1,196,807 | -417,910 | 4.59 | 4.44 | -0.15 | sell |
| Kynam Capital Management, LP | 8,520,000 | 8,050,959 | -469,041 | 9.76 | 11.01 | +1.25 | sell |