| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 815,359 | 1,456,518 | +641,159 | 0.04 | 0.09 | +0.05 | buy |
| Blue Owl Capital Holdings LP | 0 | 355,377 | +355,377 | 0.00 | 0.46 | +0.46 | buy |
| Alyeska Investment Group, L.P. | 240,029 | 486,560 | +246,531 | 0.01 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 30,576 | 80,652 | +50,076 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 43,900 | +43,900 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 17,960 | 56,570 | +38,610 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 12,231 | 48,051 | +35,820 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 19,988 | +19,988 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 78,000 | 97,276 | +19,276 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 16,785 | +16,785 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 14,481 | +14,481 | 0.00 | 0.02 | +0.02 | buy |
| Virtu Financial LLC | 0 | 12,301 | +12,301 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 110,701 | 120,776 | +10,075 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 13,305 | 22,125 | +8,820 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 0 | 7,582 | +7,582 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 41,926 | 46,818 | +4,892 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 1,100 | 4,500 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 1,247 | +1,247 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 858 | +858 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 2,681 | 2,760 | +79 | 0.00 | 0.00 | -0.00 | buy |
| Artal Group S.A. | 924,771 | 924,771 | 0 | 0.35 | 0.17 | -0.18 | hold |
| Ameritas Investment Partners, Inc. | 525 | 525 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFM Health Sciences, LP | 676,453 | 676,453 | 0 | 0.28 | 0.22 | -0.06 | hold |
| NEA Management Company, LLC | 3,850,275 | 3,850,275 | 0 | 2.09 | 1.25 | -0.84 | hold |
| DUMAC, INC. | 204,123 | 204,123 | 0 | 4.82 | 3.41 | -1.41 | hold |
| Rock Springs Capital Management LP | 738,355 | 738,355 | 0 | 0.17 | 0.10 | -0.08 | hold |
| Yu Fan | 57,190 | 57,190 | 0 | 35.70 | 1.55 | -34.15 | hold |
| Altium Capital Management LLC | 483,181 | 483,181 | 0 | 2.46 | 1.74 | -0.72 | hold |
| HHLR ADVISORS, LTD. | 1,449,543 | 1,449,543 | 0 | 0.28 | 0.16 | -0.13 | hold |
| Ghisallo Capital Management LLC | 60,000 | 60,000 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Legal & General Group Plc | 487 | 487 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,357 | 6,357 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,562 | 12,562 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 300,171 | 300,169 | -2 | 0.03 | 0.02 | -0.01 | sell |
| AMALGAMATED BANK | 584 | 529 | -55 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 5,490 | 5,304 | -186 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,185 | 914 | -271 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,526 | 2,004 | -522 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 246,018 | 245,088 | -930 | 0.00 | 0.00 | -0.00 | sell |
| Sandia Investment Management LP | 10,000 | 5,986 | -4,014 | 0.02 | 0.02 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 19,654 | 0 | -19,654 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 35,000 | 0 | -35,000 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 0 | -100,000 | 0.33 | 0.00 | -0.33 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 383,913 | 111,752 | -272,161 | 0.13 | 0.02 | -0.11 | sell |
| CITADEL ADVISORS LLC | 311,634 | 0 | -311,634 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 400,277 | 0 | -400,277 | 0.07 | 0.00 | -0.07 | sell |
| VR Adviser, LLC | 515,000 | 0 | -515,000 | 0.48 | 0.00 | -0.48 | sell |
| FMR LLC | 2,672,355 | 1,922,056 | -750,299 | 0.00 | 0.00 | -0.00 | sell |