| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 3,491,249 | 3,598,973 | +107,724 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,167,463 | 3,162,533 | -4,930 | 0.01 | 0.01 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 2,816,294 | 3,062,558 | +246,264 | 0.63 | 0.47 | -0.16 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,956,513 | 1,951,208 | -5,305 | 0.04 | 0.02 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,729,413 | 1,753,013 | +23,600 | 0.01 | 0.01 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,343,628 | 1,486,544 | +142,916 | 1.11 | 0.93 | -0.18 | buy |
| Eversept Partners, LP | 1,426,497 | 1,328,454 | -98,043 | 0.57 | 0.33 | -0.23 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 452,971 | 950,146 | +497,175 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 372,249 | 738,902 | +366,653 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 568,293 | 605,977 | +37,684 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 172,482 | 514,038 | +341,556 | 0.00 | 0.00 | +0.00 | buy |
| GLOBEFLEX CAPITAL L P | 491,751 | 452,606 | -39,145 | 0.25 | 0.15 | -0.10 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 385,863 | 354,514 | -31,349 | 0.01 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 46,604 | 334,107 | +287,503 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 617,602 | 323,725 | -293,877 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 188,893 | 308,997 | +120,104 | 0.00 | 0.00 | -0.00 | buy |
| WINTON GROUP Ltd | 188,283 | 300,599 | +112,316 | 0.07 | 0.07 | -0.00 | buy |
| SEI INVESTMENTS CO | 289,677 | 289,537 | -140 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 387,178 | 273,158 | -114,020 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 382,679 | 256,263 | -126,416 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.13 | +0.13 | buy |
| GOLDMAN SACHS GROUP INC | 450,580 | 200,584 | -249,996 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 238,491 | 200,085 | -38,406 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 200,000 | +200,000 | 0.00 | 0.07 | +0.07 | buy |
| GSA CAPITAL PARTNERS LLP | 187,585 | 189,751 | +2,166 | 0.08 | 0.04 | -0.04 | buy |
| FEDERATED HERMES, INC. | 160,924 | 160,233 | -691 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 0 | 159,300 | +159,300 | 0.00 | 0.00 | +0.00 | buy |
| Prospera Financial Services Inc | 147,792 | 149,570 | +1,778 | 0.02 | 0.01 | -0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 140,106 | 144,792 | +4,686 | 0.04 | 0.03 | -0.01 | buy |
| Assenagon Asset Management S.A. | 70,145 | 140,205 | +70,060 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 139,400 | 139,400 | 0 | 0.02 | 0.01 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 255,300 | 135,400 | -119,900 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,453 | 126,240 | +106,787 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 118,832 | +118,832 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 211,682 | 117,665 | -94,017 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 49,466 | 107,903 | +58,437 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 83,537 | 105,058 | +21,521 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 102,820 | +102,820 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 91,690 | 93,082 | +1,392 | 0.00 | 0.00 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 230,425 | 92,174 | -138,251 | 0.00 | 0.00 | -0.00 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 77,081 | 84,211 | +7,130 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 60,634 | 71,391 | +10,757 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF MONTREAL /CAN/ | 107,900 | 70,352 | -37,548 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 62,784 | 61,255 | -1,529 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 2,086 | 50,270 | +48,184 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 54,153 | 48,611 | -5,542 | 0.04 | 0.01 | -0.03 | sell |
| Alpine Global Management, LLC | 0 | 40,116 | +40,116 | 0.00 | 0.02 | +0.02 | buy |
| Metis Global Partners, LLC | 39,527 | 39,527 | 0 | 0.01 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 81,694 | 34,298 | -47,396 | 0.00 | 0.00 | -0.00 | sell |
| RITHOLTZ WEALTH MANAGEMENT | 37,324 | 33,759 | -3,565 | 0.01 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 32,199 | 32,668 | +469 | 0.00 | 0.00 | -0.00 | buy |
| Brandywine Global Investment Management, LLC | 0 | 32,210 | +32,210 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 17,324 | 31,651 | +14,327 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 31,000 | +31,000 | 0.00 | 0.00 | +0.00 | buy |
| LSV ASSET MANAGEMENT | 30,400 | 30,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of Wyoming | 6,650 | 26,963 | +20,313 | 0.01 | 0.01 | +0.01 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 21,007 | +21,007 | 0.00 | 0.07 | +0.07 | buy |
| LPL Financial LLC | 20,677 | 20,677 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 130,473 | 19,860 | -110,613 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Advisor Solutions, LLC | 19,220 | 19,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 17,765 | +17,765 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,200 | 17,585 | +2,385 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 16,565 | +16,565 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,316 | 16,450 | +8,134 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 15,603 | +15,603 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 70,300 | 14,236 | -56,064 | 0.15 | 0.01 | -0.14 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 13,357 | +13,357 | 0.00 | 0.00 | 0.00 | buy |
| ROYCE & ASSOCIATES LP | 11,738 | 11,738 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDT Partners, LLC | 0 | 11,131 | +11,131 | 0.00 | 0.00 | +0.00 | buy |
| Patriot Financial Group Insurance Agency, LLC | 11,500 | 11,000 | -500 | 0.01 | 0.01 | -0.00 | sell |
| MetLife Investment Management, LLC | 0 | 10,973 | +10,973 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 10,790 | 10,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 0 | 4,055 | +4,055 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 3,912 | +3,912 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 947 | 3,498 | +2,551 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 242 | 3,220 | +2,978 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 2,999 | +2,999 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 1,432 | +1,432 | 0.00 | 0.00 | +0.00 | buy |
| GHP Investment Advisors, Inc. | 1,170 | 1,170 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GPS Wealth Strategies Group, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 775 | 775 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aspire Private Capital, LLC | 700 | 700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Concord Wealth Partners | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| ELEVATION WEALTH PARTNERS, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OMERS ADMINISTRATION Corp | 16,800 | 0 | -16,800 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 32,709 | 0 | -32,709 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 10,740 | 0 | -10,740 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 131,175 | 0 | -131,175 | 0.02 | 0.00 | -0.02 | sell |
| Camber Capital Management LP | 1,650,000 | 0 | -1,650,000 | 0.31 | 0.00 | -0.31 | sell |
| HRT FINANCIAL LP | 127,231 | 0 | -127,231 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 49,875 | 0 | -49,875 | 0.02 | 0.00 | -0.02 | sell |
| Tower Research Capital LLC (TRC) | 1,692 | 0 | -1,692 | 0.00 | 0.00 | -0.00 | sell |
| Crestline Management, LP | 35,832 | 0 | -35,832 | 0.02 | 0.00 | -0.02 | sell |
| CTC Alternative Strategies, Ltd. | 12,100 | 0 | -12,100 | 0.04 | 0.00 | -0.04 | sell |
| Headlands Technologies LLC | 2,301 | 0 | -2,301 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 11,006 | 0 | -11,006 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 429,251 | 0 | -429,251 | 0.00 | 0.00 | -0.00 | sell |