| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 4,326,710 | 4,326,710 | 0 | 0.19 | 0.25 | +0.05 | hold |
| ARMISTICE CAPITAL, LLC | 2,189,000 | 2,297,000 | +108,000 | 0.10 | 0.13 | +0.02 | buy |
| VANGUARD GROUP INC | 695,418 | 969,121 | +273,703 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 689,340 | 651,939 | -37,401 | 0.01 | 0.01 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 443,001 | 443,001 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 176,039 | 180,901 | +4,862 | 0.00 | 0.00 | +0.00 | buy |
| CM Management, LLC | 140,000 | 160,000 | +20,000 | 0.20 | 0.28 | +0.07 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 99,778 | +99,778 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 69,173 | 87,069 | +17,896 | 0.00 | 0.00 | +0.00 | buy |
| JMAC ENTERPRISES LLC | 58,041 | 58,041 | 0 | 0.02 | 0.02 | -0.00 | hold |
| INGALLS & SNYDER LLC | 51,849 | 51,849 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 50,800 | +50,800 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 44,692 | 44,692 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 39,900 | 39,804 | -96 | 0.00 | 0.00 | +0.00 | sell |
| MARCO INVESTMENT MANAGEMENT LLC | 0 | 24,809 | +24,809 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 16,726 | 16,726 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,987 | 14,987 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 22,867 | 13,875 | -8,992 | 0.00 | 0.00 | -0.00 | sell |
| Pathstone Holdings, LLC | 13,029 | 13,029 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 5,636 | 5,674 | +38 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 22 | 22 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA SECURITIES, LLC | 11,780 | 0 | -11,780 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 3,223 | 0 | -3,223 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |