| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 269,025 | 1,585,648 | +1,316,623 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 118,861 | 810,876 | +692,015 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 690,170 | +690,170 | 0.00 | 0.13 | +0.13 | buy |
| 22NW, LP | 0 | 636,364 | +636,364 | 0.00 | 1.45 | +1.45 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 188,485 | +188,485 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 113,275 | +113,275 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 144,845 | 258,106 | +113,261 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 122,275 | 224,600 | +102,325 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 23,033 | 116,175 | +93,142 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 67,212 | +67,212 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,894,639 | 2,953,127 | +58,488 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 122,141 | 175,891 | +53,750 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 37,783 | +37,783 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 617,624 | 652,621 | +34,997 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 32,623 | 61,520 | +28,897 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 28,713 | +28,713 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 187,001 | 213,101 | +26,100 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 21,733 | +21,733 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 21,342 | +21,342 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 16,523 | +16,523 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 15,089 | +15,089 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 13,620 | +13,620 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 13,613 | +13,613 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 12,080 | +12,080 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,065 | +12,065 | 0.00 | 0.00 | +0.00 | buy |
| Capula Management Ltd | 0 | 10,170 | +10,170 | 0.00 | 0.00 | +0.00 | buy |
| CW Advisors, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 750,000 | 754,970 | +4,970 | 0.05 | 0.05 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,944 | 12,478 | +4,534 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 126,885 | 130,673 | +3,788 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 663,101 | 666,717 | +3,616 | 0.00 | 0.00 | -0.00 | buy |
| N.E.W. Advisory Services LLC | 0 | 626 | +626 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 16,000 | 16,600 | +600 | 0.01 | 0.01 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 625 | 725 | +100 | 0.00 | 0.00 | -0.00 | buy |
| INGALLS & SNYDER LLC | 51,849 | 51,849 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BVF INC/IL | 6,293,282 | 6,293,282 | 0 | 0.88 | 0.87 | -0.01 | hold |
| MARCO INVESTMENT MANAGEMENT LLC | 30,344 | 30,344 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 33,400 | 33,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sanofi | 814,980 | 814,980 | 0 | 1.93 | 1.66 | -0.26 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 3,566,338 | 3,566,338 | 0 | 0.20 | 0.20 | +0.01 | hold |
| Alyeska Investment Group, L.P. | 933,475 | 933,475 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 1,264,919 | 1,264,919 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Informed Momentum Co LLC | 109,555 | 109,555 | 0 | 0.06 | 0.06 | +0.00 | hold |
| AWM Investment Company, Inc. | 1,100,473 | 1,100,473 | 0 | 0.55 | 0.51 | -0.04 | hold |
| First Light Asset Management, LLC | 2,328,768 | 2,328,768 | 0 | 0.92 | 0.90 | -0.02 | hold |
| IFS Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 1,671,822 | 1,671,822 | 0 | 0.05 | 0.04 | -0.01 | hold |
| CM Management, LLC | 275,000 | 275,000 | 0 | 1.01 | 0.94 | -0.08 | hold |
| Addison Advisors LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Velan Capital Investment Management LP | 323,973 | 323,973 | 0 | 1.15 | 1.13 | -0.02 | hold |
| Allostery Investments LP | 100,000 | 100,000 | 0 | 0.81 | 0.49 | -0.32 | hold |
| Pathstone Holdings, LLC | 39,814 | 39,814 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clarity Capital Partners LLC | 11,500 | 11,500 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Kera Capital Partners, Inc. | 25,770 | 25,770 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Persistent Asset Partners Ltd | 14,855 | 14,855 | 0 | 0.06 | 0.04 | -0.01 | hold |
| BARCLAYS PLC | 70,000 | 70,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 16,726 | 16,726 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,987 | 29,987 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 591 | 591 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 22,000 | 22,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 43 | 4 | -39 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 10,437 | 9,991 | -446 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 4,462 | 1,782 | -2,680 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 48,310 | 44,436 | -3,874 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 62,800 | 56,500 | -6,300 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 1,147,946 | 1,141,237 | -6,709 | 0.33 | 0.32 | -0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 18,379 | 10,866 | -7,513 | 0.02 | 0.01 | -0.01 | sell |
| DIADEMA PARTNERS LP | 75,794 | 64,613 | -11,181 | 0.35 | 0.18 | -0.18 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 11,303 | 0 | -11,303 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 13,471 | 0 | -13,471 | 0.02 | 0.00 | -0.02 | sell |
| Virtu Financial LLC | 20,016 | 0 | -20,016 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 147,173 | 122,773 | -24,400 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 24,568 | 0 | -24,568 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 341,923 | 312,158 | -29,765 | 0.04 | 0.04 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 74,576 | 39,371 | -35,205 | 0.03 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 66,900 | 21,011 | -45,889 | 0.00 | 0.00 | -0.00 | sell |
| JMAC ENTERPRISES LLC | 58,041 | 0 | -58,041 | 0.04 | 0.00 | -0.04 | sell |
| MARSHALL WACE, LLP | 80,431 | 19,200 | -61,231 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 95,142 | 0 | -95,142 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 189,870 | 93,997 | -95,873 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 1,126,637 | 1,025,221 | -101,416 | 1.33 | 1.13 | -0.19 | sell |
| Blue Owl Capital Holdings LP | 1,959,912 | 1,819,912 | -140,000 | 1.86 | 1.99 | +0.13 | sell |
| Exome Asset Management LLC | 256,373 | 114,145 | -142,228 | 0.79 | 0.35 | -0.45 | sell |
| 683 Capital Management, LLC | 154,960 | 0 | -154,960 | 0.06 | 0.00 | -0.06 | sell |
| Inspire Investing, LLC | 194,688 | 0 | -194,688 | 0.09 | 0.00 | -0.09 | sell |
| Schonfeld Strategic Advisors LLC | 1,515,750 | 1,318,842 | -196,908 | 0.04 | 0.03 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 235,750 | 0 | -235,750 | 0.98 | 0.00 | -0.98 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 2,551,619 | 2,307,119 | -244,500 | 1.94 | 1.93 | -0.01 | sell |
| UBS Group AG | 318,581 | 0 | -318,581 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 1,095,000 | 0 | -1,095,000 | 0.01 | 0.00 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 1,176,735 | 0 | -1,176,735 | 0.20 | 0.00 | -0.20 | sell |