| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Zimmer Partners, LP | 0 | 2,109,704 | +2,109,704 | 0.00 | 0.11 | +0.11 | buy |
| BVF INC/IL | 4,326,710 | 6,293,282 | +1,966,572 | 0.25 | 0.47 | +0.22 | buy |
| Schonfeld Strategic Advisors LLC | 50,800 | 1,500,000 | +1,449,200 | 0.00 | 0.03 | +0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 1,297,021 | +1,297,021 | 0.00 | 0.56 | +0.56 | buy |
| Nantahala Capital Management, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.16 | +0.16 | buy |
| Alyeska Investment Group, L.P. | 0 | 500,000 | +500,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 180,901 | 344,489 | +163,588 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 969,121 | 1,104,395 | +135,274 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 44,692 | 161,492 | +116,800 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 55,001 | +55,001 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 39,804 | 91,893 | +52,089 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 87,069 | 136,773 | +49,704 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,297,000 | 2,336,000 | +39,000 | 0.13 | 0.16 | +0.04 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 33,400 | +33,400 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 30,233 | +30,233 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 651,939 | 675,243 | +23,304 | 0.01 | 0.02 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,674 | 16,958 | +11,284 | 0.00 | 0.00 | +0.00 | buy |
| MARCO INVESTMENT MANAGEMENT LLC | 24,809 | 30,344 | +5,535 | 0.00 | 0.01 | +0.00 | buy |
| INGALLS & SNYDER LLC | 51,849 | 51,849 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 443,001 | 443,001 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CM Management, LLC | 160,000 | 160,000 | 0 | 0.28 | 0.39 | +0.11 | hold |
| JMAC ENTERPRISES LLC | 58,041 | 58,041 | 0 | 0.02 | 0.03 | +0.00 | hold |
| Pathstone Holdings, LLC | 13,029 | 13,029 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 16,726 | 16,726 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,987 | 14,987 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 13,875 | 0 | -13,875 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,778 | 0 | -99,778 | 0.00 | 0.00 | -0.00 | sell |