| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 6,293,282 | 6,293,282 | 0 | 0.87 | 0.61 | -0.26 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 3,566,338 | 3,566,338 | 0 | 0.20 | 0.16 | -0.04 | hold |
| VANGUARD GROUP INC | 2,953,127 | 3,318,383 | +365,256 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 652,621 | 3,254,152 | +2,601,531 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 2,328,768 | 2,600,498 | +271,730 | 0.90 | 0.91 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 2,307,119 | 1,959,610 | -347,509 | 1.93 | 1.39 | -0.54 | sell |
| Woodline Partners LP | 1,671,822 | 1,671,822 | 0 | 0.04 | 0.02 | -0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 666,717 | 1,383,940 | +717,223 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 1,819,912 | 1,329,912 | -490,000 | 1.99 | 1.16 | -0.83 | sell |
| Ensign Peak Advisors, Inc | 1,264,919 | 1,264,919 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Nantahala Capital Management, LLC | 1,141,237 | 1,141,237 | 0 | 0.32 | 0.22 | -0.10 | hold |
| AWM Investment Company, Inc. | 1,100,473 | 1,100,473 | 0 | 0.51 | 0.33 | -0.18 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,585,648 | 1,018,919 | -566,729 | 0.01 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 1,025,221 | 1,000,221 | -25,000 | 1.13 | 0.90 | -0.24 | sell |
| Schonfeld Strategic Advisors LLC | 1,318,842 | 998,454 | -320,388 | 0.03 | 0.02 | -0.01 | sell |
| Zimmer Partners, LP | 754,970 | 980,682 | +225,712 | 0.05 | 0.06 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 933,475 | 933,475 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Sanofi | 814,980 | 814,980 | 0 | 1.66 | 1.26 | -0.41 | hold |
| Siren, L.L.C. | 690,170 | 690,170 | 0 | 0.13 | 0.10 | -0.04 | hold |
| 22NW, LP | 636,364 | 636,364 | 0 | 1.45 | 1.09 | -0.36 | hold |
| STATE STREET CORP | 213,101 | 605,340 | +392,239 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 130,673 | 454,077 | +323,404 | 0.00 | 0.00 | +0.00 | buy |
| CM Management, LLC | 275,000 | 375,000 | +100,000 | 0.94 | 0.93 | -0.01 | buy |
| Velan Capital Investment Management LP | 323,973 | 338,973 | +15,000 | 1.13 | 0.92 | -0.21 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 312,158 | 293,565 | -18,593 | 0.04 | 0.02 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 122,773 | 190,673 | +67,900 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,987 | 177,249 | +147,262 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 810,876 | 171,669 | -639,207 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 93,997 | 152,460 | +58,463 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 116,175 | 136,456 | +20,281 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 0 | 134,322 | +134,322 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 114,145 | 114,145 | 0 | 0.35 | 0.26 | -0.09 | hold |
| BARCLAYS PLC | 70,000 | 101,878 | +31,878 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 19,200 | 94,772 | +75,572 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 76,292 | +76,292 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 64,613 | 64,613 | 0 | 0.18 | 0.11 | -0.07 | hold |
| RHUMBLINE ADVISERS | 0 | 56,050 | +56,050 | 0.00 | 0.00 | +0.00 | buy |
| INGALLS & SNYDER LLC | 51,849 | 51,849 | 0 | 0.01 | 0.01 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 0 | 37,156 | +37,156 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 36,400 | +36,400 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 36,264 | +36,264 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 39,371 | 36,141 | -3,230 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 35,592 | +35,592 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 33,400 | 33,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 32,052 | +32,052 | 0.00 | 0.00 | +0.00 | buy |
| MARCO INVESTMENT MANAGEMENT LLC | 30,344 | 30,344 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HOWARD FINANCIAL SERVICES, LTD. | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 29,740 | +29,740 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 29,499 | +29,499 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 39,814 | 29,464 | -10,350 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 29,176 | +29,176 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 29,058 | +29,058 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 27,698 | +27,698 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 0 | 27,366 | +27,366 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 258,106 | 26,871 | -231,235 | 0.00 | 0.00 | -0.00 | sell |
| Kera Capital Partners, Inc. | 25,770 | 25,770 | 0 | 0.03 | 0.01 | -0.01 | hold |
| CITIGROUP INC | 21,011 | 19,738 | -1,273 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 18,113 | +18,113 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 16,600 | 16,900 | +300 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 28,713 | 16,744 | -11,969 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 16,726 | 16,726 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Persistent Asset Partners Ltd | 14,855 | 14,855 | 0 | 0.04 | 0.04 | -0.01 | hold |
| Police & Firemen's Retirement System of New Jersey | 0 | 13,496 | +13,496 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,019 | +12,019 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 11,597 | +11,597 | 0.00 | 0.05 | +0.05 | buy |
| Clarity Capital Partners LLC | 11,500 | 11,500 | 0 | 0.02 | 0.01 | -0.00 | hold |
| CW Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 9,991 | 8,273 | -1,718 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 0 | 5,984 | +5,984 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 5,333 | +5,333 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4,988 | +4,988 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 3,657 | +3,657 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 2,002 | +2,002 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 1,493 | +1,493 | 0.00 | 0.00 | +0.00 | buy |
| Addison Advisors LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Advisory Services, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 4 | 144 | +140 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 591 | 20 | -571 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 56,500 | 0 | -56,500 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 61,520 | 0 | -61,520 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 15,089 | 0 | -15,089 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 44,436 | 0 | -44,436 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 13,613 | 0 | -13,613 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 113,275 | 0 | -113,275 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 109,555 | 0 | -109,555 | 0.06 | 0.00 | -0.06 | sell |
| Brevan Howard Capital Management LP | 12,080 | 0 | -12,080 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 12,478 | 0 | -12,478 | 0.00 | 0.00 | -0.00 | sell |
| Capula Management Ltd | 10,170 | 0 | -10,170 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 37,783 | 0 | -37,783 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 224,600 | 0 | -224,600 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 10,866 | 0 | -10,866 | 0.01 | 0.00 | -0.01 | sell |
| Qube Research & Technologies Ltd | 175,891 | 0 | -175,891 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 21,733 | 0 | -21,733 | 0.00 | 0.00 | -0.00 | sell |
| IFS Advisors, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 12,065 | 0 | -12,065 | 0.00 | 0.00 | -0.00 | sell |
| N.E.W. Advisory Services LLC | 626 | 0 | -626 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 13,620 | 0 | -13,620 | 0.01 | 0.00 | -0.01 | sell |
| Allostery Investments LP | 100,000 | 0 | -100,000 | 0.49 | 0.00 | -0.49 | sell |
| Quantessence Capital LLC | 16,523 | 0 | -16,523 | 0.01 | 0.00 | -0.01 | sell |
| Point72 (DIFC) Ltd | 1,782 | 0 | -1,782 | 0.00 | 0.00 | -0.00 | sell |