| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 6,293,282 | 6,293,282 | 0 | 0.47 | 0.46 | -0.01 | hold |
| ARMISTICE CAPITAL, LLC | 2,336,000 | 2,364,000 | +28,000 | 0.16 | 0.15 | -0.01 | buy |
| VANGUARD GROUP INC | 1,104,395 | 1,565,487 | +461,092 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 1,500,000 | 1,500,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Zimmer Partners, LP | 2,109,704 | 1,434,727 | -674,977 | 0.11 | 0.07 | -0.04 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,297,021 | 1,297,321 | +300 | 0.56 | 0.53 | -0.03 | buy |
| Woodline Partners LP | 675,243 | 842,892 | +167,649 | 0.02 | 0.02 | +0.00 | buy |
| Nantahala Capital Management, LLC | 600,000 | 600,000 | 0 | 0.16 | 0.13 | -0.03 | hold |
| Alyeska Investment Group, L.P. | 500,000 | 500,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 443,001 | 443,001 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 344,489 | 378,058 | +33,569 | 0.00 | 0.00 | -0.00 | buy |
| CM Management, LLC | 160,000 | 275,000 | +115,000 | 0.39 | 0.55 | +0.16 | buy |
| STATE STREET CORP | 161,492 | 161,492 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 136,773 | 135,873 | -900 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 91,893 | 91,893 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JMAC ENTERPRISES LLC | 58,041 | 58,041 | 0 | 0.03 | 0.02 | -0.00 | hold |
| INGALLS & SNYDER LLC | 51,849 | 51,849 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 30,233 | 34,223 | +3,990 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 33,400 | 33,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARCO INVESTMENT MANAGEMENT LLC | 30,344 | 30,344 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 16,726 | 16,726 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,987 | 14,987 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pathstone Holdings, LLC | 13,029 | 13,029 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clarity Capital Partners LLC | 0 | 11,500 | +11,500 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,027 | +11,027 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 16,958 | 1,532 | -15,426 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 55,001 | 0 | -55,001 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |