| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 3,566,338 | +3,566,338 | 0.00 | 0.20 | +0.20 | buy |
| First Light Asset Management, LLC | 0 | 2,328,768 | +2,328,768 | 0.00 | 0.92 | +0.92 | buy |
| Blue Owl Capital Holdings LP | 0 | 1,959,912 | +1,959,912 | 0.00 | 1.86 | +1.86 | buy |
| VANGUARD GROUP INC | 1,565,487 | 2,894,639 | +1,329,152 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,297,321 | 2,551,619 | +1,254,298 | 0.53 | 1.94 | +1.41 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,176,735 | +1,176,735 | 0.00 | 0.20 | +0.20 | buy |
| Ikarian Capital, LLC | 0 | 1,126,637 | +1,126,637 | 0.00 | 1.33 | +1.33 | buy |
| AWM Investment Company, Inc. | 0 | 1,100,473 | +1,100,473 | 0.00 | 0.55 | +0.55 | buy |
| Point72 Asset Management, L.P. | 0 | 1,095,000 | +1,095,000 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 842,892 | 1,671,822 | +828,930 | 0.02 | 0.05 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 443,001 | 1,264,919 | +821,918 | 0.00 | 0.01 | +0.01 | buy |
| Nantahala Capital Management, LLC | 600,000 | 1,147,946 | +547,946 | 0.13 | 0.33 | +0.21 | buy |
| Alyeska Investment Group, L.P. | 500,000 | 933,475 | +433,475 | 0.01 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 215,868 | 617,624 | +401,756 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 341,923 | +341,923 | 0.00 | 0.04 | +0.04 | buy |
| Velan Capital Investment Management LP | 0 | 323,973 | +323,973 | 0.00 | 1.15 | +1.15 | buy |
| UBS Group AG | 0 | 318,581 | +318,581 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 378,058 | 663,101 | +285,043 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 269,025 | +269,025 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 256,373 | +256,373 | 0.00 | 0.79 | +0.79 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 235,750 | +235,750 | 0.00 | 0.98 | +0.98 | buy |
| Inspire Investing, LLC | 0 | 194,688 | +194,688 | 0.00 | 0.09 | +0.09 | buy |
| CITADEL ADVISORS LLC | 0 | 189,870 | +189,870 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 154,960 | +154,960 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 144,845 | +144,845 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 122,275 | +122,275 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 122,141 | +122,141 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 118,861 | +118,861 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 109,555 | +109,555 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 95,142 | +95,142 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 80,431 | +80,431 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 74,576 | +74,576 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 66,900 | +66,900 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 62,800 | +62,800 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 48,310 | +48,310 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 91,893 | 126,885 | +34,992 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 32,623 | +32,623 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 13,029 | 39,814 | +26,785 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 161,492 | 187,001 | +25,509 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 24,568 | +24,568 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 22,000 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 20,016 | +20,016 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 18,379 | +18,379 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 0 | 16,000 | +16,000 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 1,500,000 | 1,515,750 | +15,750 | 0.03 | 0.04 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,987 | 29,987 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 13,471 | +13,471 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 11,303 | +11,303 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 135,873 | 147,173 | +11,300 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 10,437 | +10,437 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,532 | 7,944 | +6,412 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 4,462 | +4,462 | 0.00 | 0.00 | +0.00 | buy |
| Addison Advisors LLC | 0 | 1,300 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 625 | +625 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 591 | +591 | 0.00 | 0.00 | +0.00 | buy |
| IFS Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| INGALLS & SNYDER LLC | 51,849 | 51,849 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BVF INC/IL | 6,293,282 | 6,293,282 | 0 | 0.46 | 0.88 | +0.42 | hold |
| MARCO INVESTMENT MANAGEMENT LLC | 30,344 | 30,344 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 33,400 | 33,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CM Management, LLC | 275,000 | 275,000 | 0 | 0.55 | 1.01 | +0.47 | hold |
| JMAC ENTERPRISES LLC | 58,041 | 58,041 | 0 | 0.02 | 0.04 | +0.01 | hold |
| Clarity Capital Partners LLC | 11,500 | 11,500 | 0 | 0.02 | 0.02 | +0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 16,726 | 16,726 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA SECURITIES, LLC | 11,027 | 0 | -11,027 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 34,223 | 23,033 | -11,190 | 0.00 | 0.00 | +0.00 | sell |
| Zimmer Partners, LP | 1,434,727 | 750,000 | -684,727 | 0.07 | 0.05 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 2,364,000 | 0 | -2,364,000 | 0.15 | 0.00 | -0.15 | sell |