| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 6,293,282 | 6,293,282 | 0 | 0.66 | 0.32 | -0.34 | hold |
| VANGUARD GROUP INC | 3,267,783 | 4,039,686 | +771,903 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 3,465,082 | 3,627,208 | +162,126 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 1,264,919 | 2,464,919 | +1,200,000 | 0.01 | 0.01 | +0.00 | buy |
| Zimmer Partners, LP | 1,825,000 | 2,384,228 | +559,228 | 0.12 | 0.09 | -0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,280,233 | 2,132,131 | +851,898 | 0.79 | 0.67 | -0.11 | buy |
| Blue Owl Capital Holdings LP | 979,912 | 1,929,912 | +950,000 | 0.79 | 0.90 | +0.11 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,821,812 | +1,821,812 | 0.00 | 0.21 | +0.21 | buy |
| Jefferies Financial Group Inc. | 0 | 1,580,625 | +1,580,625 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,368,940 | 1,421,617 | +52,677 | 0.00 | 0.00 | -0.00 | buy |
| Catalio Capital Management, LP | 1,061,132 | 1,259,820 | +198,688 | 0.51 | 0.34 | -0.17 | buy |
| AWM Investment Company, Inc. | 0 | 1,100,000 | +1,100,000 | 0.00 | 0.16 | +0.16 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 1,039,275 | +1,039,275 | 0.00 | 0.24 | +0.24 | buy |
| Stonepine Capital Management, LLC | 0 | 893,100 | +893,100 | 0.00 | 1.07 | +1.07 | buy |
| Sanofi | 814,980 | 814,980 | 0 | 0.81 | 0.40 | -0.41 | hold |
| STATE STREET CORP | 655,476 | 773,885 | +118,409 | 0.00 | 0.00 | -0.00 | buy |
| CM Management, LLC | 600,000 | 650,000 | +50,000 | 1.30 | 0.83 | -0.47 | buy |
| 22NW, LP | 636,364 | 636,364 | 0 | 0.78 | 0.40 | -0.37 | hold |
| SG Americas Securities, LLC | 0 | 627,392 | +627,392 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 593,131 | +593,131 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 0 | 555,978 | +555,978 | 0.00 | 0.08 | +0.08 | buy |
| JANE STREET GROUP, LLC | 195,201 | 489,376 | +294,175 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 428,562 | 429,813 | +1,251 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 0 | 317,443 | +317,443 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 61,006 | 198,712 | +137,706 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 195,757 | +195,757 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 349,200 | 176,990 | -172,210 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 162,842 | 173,131 | +10,289 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 151,569 | +151,569 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 145,872 | 132,902 | -12,970 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 12,848 | 124,247 | +111,399 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 134,761 | 115,682 | -19,079 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 27,100 | 106,014 | +78,914 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 79,753 | 87,472 | +7,719 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 76,292 | 76,292 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 36,666 | 71,666 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 70,260 | +70,260 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 48,552 | 68,906 | +20,354 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 60,215 | +60,215 | 0.00 | 0.00 | +0.00 | buy |
| INGALLS & SNYDER LLC | 51,849 | 51,849 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 53,564 | 44,617 | -8,947 | 0.00 | 0.00 | -0.00 | sell |
| Kera Capital Partners, Inc. | 25,770 | 39,770 | +14,000 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 31,891 | 31,669 | -222 | 0.00 | 0.00 | -0.00 | sell |
| MARCO INVESTMENT MANAGEMENT LLC | 30,344 | 30,344 | 0 | 0.01 | 0.00 | -0.00 | hold |
| HOWARD FINANCIAL SERVICES, LTD. | 30,000 | 30,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MARSHALL WACE, LLP | 0 | 29,547 | +29,547 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,499 | 29,499 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 29,400 | +29,400 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,669 | 27,351 | +16,682 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,583 | 26,755 | -828 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 15,377 | 26,584 | +11,207 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 25,920 | +25,920 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 23,788 | +23,788 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,900 | 22,850 | -3,050 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 0 | 19,345 | +19,345 | 0.00 | 0.00 | +0.00 | buy |
| TIAA TRUST, NATIONAL ASSOCIATION | 0 | 19,000 | +19,000 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 16,803 | 17,684 | +881 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 12,414 | +12,414 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 12,154 | 11,883 | -271 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 21,293 | 11,856 | -9,437 | 0.00 | 0.00 | -0.00 | sell |
| Summit Financial, LLC | 11,500 | 11,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 11,420 | 11,420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 4,854 | 10,781 | +5,927 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,266 | +10,266 | 0.00 | 0.00 | +0.00 | buy |
| Forum Private Client Group LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 5,984 | 5,984 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 5,333 | 5,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 0 | 4,686 | +4,686 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 3,644 | 3,659 | +15 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,660 | 3,455 | -205 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 0 | 2,011 | +2,011 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,002 | 1,765 | -237 | 0.00 | 0.00 | -0.00 | sell |
| Addison Advisors LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 810 | 1,279 | +469 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 349 | +349 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 111 | 63 | -48 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Byrne Asset Management LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 33,400 | 0 | -33,400 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 3,566,338 | 0 | -3,566,338 | 0.11 | 0.00 | -0.11 | sell |
| BRIGHTON JONES LLC | 39,355 | 0 | -39,355 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 1,141,237 | 0 | -1,141,237 | 0.18 | 0.00 | -0.18 | sell |
| SIMPLEX TRADING, LLC | 15,997 | 0 | -15,997 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 152 | 0 | -152 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 36,297 | 0 | -36,297 | 0.00 | 0.00 | -0.00 | sell |
| Kovitz Investment Group Partners, LLC | 732,975 | 0 | -732,975 | 0.01 | 0.00 | -0.01 | sell |
| Woodline Partners LP | 800,822 | 0 | -800,822 | 0.01 | 0.00 | -0.01 | sell |
| Velan Capital Investment Management LP | 346,973 | 0 | -346,973 | 0.84 | 0.00 | -0.84 | sell |
| Catalyst Funds Management Pty Ltd | 11,400 | 0 | -11,400 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 2,072,767 | 0 | -2,072,767 | 0.21 | 0.00 | -0.21 | sell |
| Redwood Park Advisors LLC | 700 | 0 | -700 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 21,572 | 0 | -21,572 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 18,628 | 0 | -18,628 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,283,939 | 0 | -1,283,939 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,072 | 0 | -19,072 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 4,217 | 0 | -4,217 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 64,110 | 0 | -64,110 | 0.00 | 0.00 | -0.00 | sell |