| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 135,581 | 171,645 | +36,064 | 0.01 | 0.02 | +0.01 | buy |
| Altium Capital Management LLC | 66,981 | 100,000 | +33,019 | 0.89 | 2.27 | +1.38 | buy |
| JANUS HENDERSON GROUP PLC | 841,688 | 813,353 | +28,335 | 0.01 | 0.02 | 0.00 | sell |
| GREAT POINT PARTNERS LLC | 994,229 | 1,004,291 | +10,062 | 3.28 | 7.97 | +4.68 | buy |
| BAKER BROS. ADVISORS LP | 453,516 | 456,015 | +2,499 | 0.10 | 0.29 | +0.19 | buy |
| Avidity Partners Management LP | 466,243 | 465,237 | -1,006 | 0.35 | 0.84 | +0.50 | sell |
| ADAR1 Capital Management, LLC | 5,405 | 661 | -4,744 | 0.05 | 0.01 | -0.04 | sell |
| Redmile Group, LLC | 946,897 | 935,252 | -11,645 | 0.66 | 1.75 | +1.09 | sell |
| ArrowMark Colorado Holdings LLC | 525,529 | 437,538 | -87,991 | 0.11 | 0.25 | +0.14 | sell |
| Cormorant Asset Management, LP | 746,180 | 538,714 | -207,466 | 0.69 | 1.20 | +0.51 | sell |