| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 0.64 | 1.64 | +1.00 | hold |
| Samsara BioCapital, LLC | 1,267,790 | 1,267,790 | 0 | 3.82 | 9.98 | +6.16 | hold |
| GREAT POINT PARTNERS LLC | 994,229 | 1,004,291 | +10,062 | 3.28 | 7.97 | +4.68 | buy |
| Redmile Group, LLC | 946,897 | 935,252 | -11,645 | 0.66 | 1.75 | +1.09 | sell |
| JANUS HENDERSON GROUP PLC | 841,688 | 813,353 | -28,335 | 0.01 | 0.02 | +0.01 | sell |
| RTW INVESTMENTS, LP | 0 | 769,122 | +769,122 | 0.00 | 0.58 | +0.58 | buy |
| Cormorant Asset Management, LP | 746,180 | 538,714 | -207,466 | 0.69 | 1.21 | +0.52 | sell |
| Casdin Capital, LLC | 524,616 | 524,616 | 0 | 1.00 | 1.99 | +0.98 | hold |
| MORGAN STANLEY | 339,979 | 516,608 | +176,629 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 50,421 | 507,483 | +457,062 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 466,243 | 465,237 | -1,006 | 0.35 | 0.84 | +0.50 | sell |
| BAKER BROS. ADVISORS LP | 453,516 | 456,015 | +2,499 | 0.10 | 0.29 | +0.19 | buy |
| ArrowMark Colorado Holdings LLC | 525,529 | 437,538 | -87,991 | 0.11 | 0.25 | +0.14 | sell |
| Commodore Capital LP | 0 | 200,000 | +200,000 | 0.00 | 0.68 | +0.68 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 135,581 | 171,645 | +36,064 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 131,258 | +131,258 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 122,364 | +122,364 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 188,501 | 100,862 | -87,639 | 0.05 | 0.06 | +0.00 | sell |
| Altium Capital Management LLC | 66,981 | 100,000 | +33,019 | 0.89 | 2.27 | +1.38 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 15,719 | 99,314 | +83,595 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 87,138 | +87,138 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 83,420 | +83,420 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 74,087 | +74,087 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 73,035 | +73,035 | 0.00 | 0.01 | +0.01 | buy |
| Nantahala Capital Management, LLC | 72,279 | 72,279 | 0 | 0.14 | 0.36 | +0.22 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 50,194 | 58,707 | +8,513 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 54,888 | +54,888 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 45,654 | +45,654 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 0 | 31,227 | +31,227 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 30,218 | +30,218 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 28,033 | +28,033 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 22,635 | +22,635 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 49,729 | 20,474 | -29,255 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 0 | 17,521 | +17,521 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 12,101 | +12,101 | 0.00 | 0.10 | +0.10 | buy |
| Marathon Trading Investment Management LLC | 0 | 12,000 | +12,000 | 0.00 | 0.24 | +0.24 | buy |
| BARCLAYS PLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 10,720 | +10,720 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 0 | 9,784 | +9,784 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 9,718 | +9,718 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 8,064 | +8,064 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 6,747 | +6,747 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 20,306 | 6,382 | -13,924 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 5,905 | +5,905 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management (UK) Ltd | 0 | 5,860 | +5,860 | 0.00 | 0.14 | +0.14 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 5,239 | +5,239 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 5,004 | +5,004 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 3,961 | +3,961 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 2,348 | +2,348 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 697 | +697 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 5,405 | 661 | -4,744 | 0.05 | 0.01 | -0.04 | sell |
| Farther Finance Advisors, LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| BML Capital Management, LLC | 24,666 | 0 | -24,666 | 0.38 | 0.00 | -0.38 | sell |
| US BANCORP \DE\ | 3,467 | 0 | -3,467 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 74 | 0 | -74 | 0.00 | 0.00 | -0.00 | sell |