| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 674,450 | 1,486,200 | +811,750 | 0.16 | 0.19 | +0.03 | buy |
| TORONTO DOMINION BANK | 0 | 239,261 | +239,261 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 157,937 | +157,937 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 800,000 | 925,000 | +125,000 | 1.34 | 0.80 | -0.54 | buy |
| Deep Track Capital, LP | 0 | 116,660 | +116,660 | 0.00 | 0.04 | +0.04 | buy |
| BLAIR WILLIAM & CO/IL | 62,640 | 151,180 | +88,540 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 568,016 | 617,935 | +49,919 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 72,596 | 108,084 | +35,488 | 0.00 | 0.00 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 442,761 | 470,964 | +28,203 | 4.77 | 3.00 | -1.77 | buy |
| ADAR1 Capital Management, LLC | 0 | 27,925 | +27,925 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 26,507 | 52,521 | +26,014 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 234,625 | 259,376 | +24,751 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 32,734 | 56,015 | +23,281 | 0.02 | 0.02 | -0.00 | buy |
| Walleye Capital LLC | 74,836 | 94,083 | +19,247 | 0.02 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 17,552 | +17,552 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 16,416 | +16,416 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 16,000 | 30,000 | +14,000 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 21,717 | 34,421 | +12,704 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 12,666 | +12,666 | 0.00 | 0.07 | +0.07 | buy |
| NORTHERN TRUST CORP | 100,566 | 110,410 | +9,844 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 95,407 | 104,339 | +8,932 | 0.08 | 0.07 | -0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 7,351 | +7,351 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 0 | 6,609 | +6,609 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 225,373 | 230,538 | +5,165 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,317 | 33,969 | +3,652 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 22,601 | 24,445 | +1,844 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 1,253 | +1,253 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,924 | 6,983 | +1,059 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,444 | 6,420 | +976 | 0.00 | 0.00 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 10,290 | 11,231 | +941 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 845 | +845 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 5,121 | 5,826 | +705 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 8,100 | 8,576 | +476 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 134 | 353 | +219 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,022 | 1,230 | +208 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 95 | 254 | +159 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 83,340 | 83,410 | +70 | 0.01 | 0.01 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 312 | 368 | +56 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 629 | 670 | +41 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 746 | 746 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 51,500 | 51,500 | 0 | 0.30 | 0.17 | -0.13 | hold |
| MetLife Investment Management, LLC | 6,054 | 6,054 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Casdin Capital, LLC | 1,295,361 | 1,295,361 | 0 | 1.98 | 1.24 | -0.74 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.16 | 0.88 | -0.28 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 1,717,127 | 1,717,127 | 0 | 5.39 | 3.59 | -1.80 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ATTICUS WEALTH MANAGEMENT, LLC | 437 | 437 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Octagon Capital Advisors LP | 303,000 | 303,000 | 0 | 1.18 | 0.48 | -0.69 | hold |
| CoreCap Advisors, LLC | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,071 | 2,071 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 356 | 356 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,765 | 32,765 | 0 | 0.01 | 0.00 | -0.00 | hold |
| CWM, LLC | 2 | 0 | -2 | 0.00 | 0.00 | 0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 495 | 491 | -4 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 15,704 | 15,693 | -11 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 35 | 15 | -20 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| Physician Wealth Advisors, Inc. | 29 | 0 | -29 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 43 | 11 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 41 | 0 | -41 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 171 | 103 | -68 | 0.00 | 0.00 | -0.00 | sell |
| Wilmington Savings Fund Society, FSB | 132 | 0 | -132 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,150 | 2,980 | -170 | 0.01 | 0.00 | -0.00 | sell |
| R Squared Ltd | 290 | 0 | -290 | 0.01 | 0.00 | -0.01 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,126 | 2,823 | -303 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,380 | 829 | -551 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 448,145 | 446,880 | -1,265 | 0.19 | 0.10 | -0.09 | sell |
| DEUTSCHE BANK AG\ | 152,371 | 150,862 | -1,509 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 1,350,256 | 1,348,656 | -1,600 | 0.47 | 0.24 | -0.23 | sell |
| VIRTUS ADVISERS, LLC | 3,183 | 0 | -3,183 | 0.03 | 0.00 | -0.03 | sell |
| BARCLAYS PLC | 17,533 | 14,229 | -3,304 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 448,601 | 441,591 | -7,010 | 0.14 | 0.08 | -0.05 | sell |
| Schonfeld Strategic Advisors LLC | 9,189 | 0 | -9,189 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 20,629 | 10,844 | -9,785 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 9,933 | 0 | -9,933 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 10,475 | 0 | -10,475 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 10,936 | 0 | -10,936 | 0.02 | 0.00 | -0.02 | sell |
| Redmile Group, LLC | 1,319,763 | 1,308,063 | -11,700 | 2.10 | 1.45 | -0.65 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,079 | 0 | -14,079 | 0.00 | 0.00 | -0.00 | sell |
| M&T BANK CORP | 14,138 | 0 | -14,138 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,256 | 0 | -15,256 | 0.03 | 0.00 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 15,800 | 0 | -15,800 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 38,058 | 21,176 | -16,882 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 17,431 | 0 | -17,431 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 329,863 | 286,112 | -43,751 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 74,778 | 0 | -74,778 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 80,000 | 0 | -80,000 | 0.11 | 0.00 | -0.11 | sell |
| BlackRock, Inc. | 1,516,157 | 1,399,133 | -117,024 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 123,291 | 0 | -123,291 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 347,201 | 208,716 | -138,485 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 481,001 | 86,978 | -394,023 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 860,333 | 462,879 | -397,454 | 0.00 | 0.00 | -0.00 | sell |