| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 674,450 | 1,486,200 | +811,750 | 0.16 | 0.19 | +0.03 | buy |
| Commodore Capital LP | 800,000 | 925,000 | +125,000 | 1.34 | 0.80 | -0.54 | buy |
| JENNISON ASSOCIATES LLC | 72,596 | 108,084 | +35,488 | 0.00 | 0.00 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 442,761 | 470,964 | +28,203 | 4.77 | 2.92 | -1.85 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 32,734 | 56,015 | +23,281 | 0.06 | 0.05 | 0.00 | buy |
| Raiffeisen Bank International AG | 16,000 | 30,000 | +14,000 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 95,407 | 104,339 | +8,932 | 0.08 | 0.07 | -0.01 | buy |
| Woodline Partners LP | 83,340 | 83,410 | +70 | 0.01 | 0.01 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 312 | 368 | +56 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,150 | 2,980 | -170 | 0.01 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 448,145 | 446,880 | -1,265 | 0.19 | 0.10 | -0.09 | sell |
| RTW INVESTMENTS, LP | 1,350,256 | 1,348,656 | -1,600 | 0.47 | 0.24 | -0.23 | sell |
| ArrowMark Colorado Holdings LLC | 448,601 | 441,591 | -7,010 | 0.14 | 0.08 | -0.05 | sell |
| Redmile Group, LLC | 1,319,763 | 1,308,063 | -11,700 | 2.10 | 1.45 | -0.65 | sell |