| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 130,329 | 382,647 | +252,318 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 350,000 | 500,000 | +150,000 | 2.34 | 2.47 | +0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 71,321 | 204,809 | +133,488 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 1,295,361 | 1,420,361 | +125,000 | 1.66 | 2.17 | +0.51 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 608,578 | 718,389 | +109,811 | 0.02 | 0.03 | +0.00 | buy |
| JPMORGAN CHASE & CO | 5,363 | 64,922 | +59,559 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 945,583 | 1,005,070 | +59,487 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 154,123 | 185,679 | +31,556 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,000 | 43,400 | +29,400 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 249,695 | 279,003 | +29,308 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 27,974 | 56,635 | +28,661 | 0.13 | 0.26 | +0.13 | buy |
| XTX Topco Ltd | 0 | 27,431 | +27,431 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 364,228 | 387,031 | +22,803 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 85,571 | 106,255 | +20,684 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 16,687 | +16,687 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 12,754 | +12,754 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 12,724 | +12,724 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 85,559 | 97,621 | +12,062 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,311 | +10,311 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,781 | 18,781 | +8,000 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 307,797 | 313,005 | +5,208 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 163,655 | 168,218 | +4,563 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 21,093 | 25,210 | +4,117 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 23,093 | 26,043 | +2,950 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 11,991 | 13,891 | +1,900 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,013 | 3,846 | +1,833 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 42,000 | 43,000 | +1,000 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 17,560 | 18,540 | +980 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 154 | 1,030 | +876 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 856 | 1,607 | +751 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,591 | 5,307 | +716 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,383 | 13,892 | +509 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 12,716 | 13,033 | +317 | 0.07 | 0.07 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 292 | +292 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,424 | 2,694 | +270 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,524 | 2,749 | +225 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 754 | 930 | +176 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 170 | +170 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 408 | 535 | +127 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 25 | 125 | +100 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,959 | 30,058 | +99 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 0 | 96 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 753 | 808 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,233 | 1,279 | +46 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 302 | 340 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 62 | 89 | +27 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 45 | 63 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 2 | 14 | +12 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 61 | 67 | +6 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,410 | 11,415 | +5 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 45 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52,300 | 52,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 10,570 | 10,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 991,691 | 991,691 | 0 | 0.12 | 0.11 | -0.00 | hold |
| Redmile Group, LLC | 1,459,599 | 1,459,599 | 0 | 2.21 | 1.95 | -0.27 | hold |
| RTW INVESTMENTS, LP | 1,362,456 | 1,362,456 | 0 | 0.28 | 0.27 | -0.01 | hold |
| MetLife Investment Management, LLC | 5,932 | 5,932 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.20 | 1.10 | -0.10 | hold |
| Rock Springs Capital Management LP | 104,339 | 104,339 | 0 | 0.11 | 0.12 | +0.01 | hold |
| EverSource Wealth Advisors, LLC | 44 | 44 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 1,717,127 | 1,717,127 | 0 | 3.65 | 3.36 | -0.29 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 83,835 | 83,835 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 898 | 898 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,765 | 32,765 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 681,337 | 681,337 | 0 | 0.02 | 0.03 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 606 | 604 | -2 | 0.00 | 0.00 | +0.00 | sell |
| Versant Capital Management, Inc | 33 | 0 | -33 | 0.00 | 0.00 | -0.00 | sell |
| SageView Advisory Group, LLC | 45 | 0 | -45 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,124 | 5,047 | -77 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 12,721 | 12,606 | -115 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 163 | 30 | -133 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 567 | 374 | -193 | 0.00 | 0.00 | -0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 8,192 | 7,994 | -198 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 309 | 0 | -309 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14,530 | 13,793 | -737 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 3,227 | 0 | -3,227 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 533,088 | 527,685 | -5,403 | 0.01 | 0.01 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 11,037 | 4,268 | -6,769 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 7,215 | 0 | -7,215 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 15,375 | 2,751 | -12,624 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 15,105 | 0 | -15,105 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 27,894 | 0 | -27,894 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 29,119 | 0 | -29,119 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 30,633 | 0 | -30,633 | 0.05 | 0.00 | -0.05 | sell |
| Squarepoint Ops LLC | 32,489 | 0 | -32,489 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 36,102 | 0 | -36,102 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 40,347 | 0 | -40,347 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 41,759 | 0 | -41,759 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 43,323 | 0 | -43,323 | 0.01 | 0.00 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 577,490 | 524,796 | -52,694 | 0.26 | 0.28 | +0.02 | sell |
| GOLDMAN SACHS GROUP INC | 162,018 | 107,714 | -54,304 | 0.00 | 0.00 | -0.00 | sell |