| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 769,122 | 1,070,565 | +301,443 | 0.58 | 0.60 | +0.03 | buy |
| Avidity Partners Management LP | 465,237 | 727,537 | +262,300 | 0.84 | 1.12 | +0.28 | buy |
| DEUTSCHE BANK AG\ | 87,138 | 332,284 | +245,146 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 31,227 | 209,853 | +178,626 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 99,314 | 222,062 | +122,748 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 78,601 | +78,601 | 0.00 | 0.84 | +0.84 | buy |
| Redmile Group, LLC | 935,252 | 1,013,663 | +78,411 | 1.75 | 2.23 | +0.48 | buy |
| FMR LLC | 0 | 72,286 | +72,286 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 70,000 | +70,000 | 0.00 | 0.25 | +0.25 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 45,654 | 102,187 | +56,533 | 0.02 | 0.04 | +0.01 | buy |
| VANGUARD GROUP INC | 507,483 | 563,525 | +56,042 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 0 | 30,428 | +30,428 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 5,239 | 29,576 | +24,337 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 0 | 22,029 | +22,029 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 813,353 | 834,791 | +21,438 | 0.02 | 0.02 | -0.01 | buy |
| RHUMBLINE ADVISERS | 0 | 13,489 | +13,489 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 122,364 | 133,694 | +11,330 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 30,218 | 41,447 | +11,229 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 0 | 11,000 | +11,000 | 0.00 | 0.10 | +0.10 | buy |
| Schonfeld Strategic Advisors LLC | 5,905 | 14,300 | +8,395 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 7,100 | +7,100 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 20,474 | 27,066 | +6,592 | 0.00 | 0.00 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 6,519 | +6,519 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 22,635 | 28,739 | +6,104 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,200 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 4,017 | +4,017 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 2,156 | +2,156 | 0.00 | 0.04 | +0.04 | buy |
| AlphaQuest LLC | 0 | 1,523 | +1,523 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 0 | 1,022 | +1,022 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,009 | +1,009 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 746 | +746 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 741 | +741 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 661 | 1,253 | +592 | 0.01 | 0.01 | -0.00 | buy |
| AMALGAMATED BANK | 0 | 356 | +356 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 456,015 | 456,015 | 0 | 0.29 | 0.21 | -0.08 | hold |
| GREAT POINT PARTNERS LLC | 1,004,291 | 1,004,291 | 0 | 7.97 | 7.00 | -0.97 | hold |
| Nantahala Capital Management, LLC | 72,279 | 72,279 | 0 | 0.36 | 0.26 | -0.10 | hold |
| Casdin Capital, LLC | 524,616 | 524,616 | 0 | 1.99 | 1.46 | -0.53 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.64 | 1.42 | -0.23 | hold |
| Samsara BioCapital, LLC | 1,267,790 | 1,267,790 | 0 | 9.98 | 9.66 | -0.33 | hold |
| Commodore Capital LP | 200,000 | 200,000 | 0 | 0.68 | 0.50 | -0.18 | hold |
| Farther Finance Advisors, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| Truvestments Capital LLC | 46 | 0 | -46 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 9,784 | 9,456 | -328 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 697 | 0 | -697 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 2,348 | 0 | -2,348 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 3,961 | 0 | -3,961 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 5,004 | 0 | -5,004 | 0.07 | 0.00 | -0.07 | sell |
| Privium Fund Management (UK) Ltd | 5,860 | 0 | -5,860 | 0.14 | 0.00 | -0.14 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 58,707 | 52,807 | -5,900 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 9,718 | 3,423 | -6,295 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 6,382 | 0 | -6,382 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 6,747 | 0 | -6,747 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 8,064 | 0 | -8,064 | 0.04 | 0.00 | -0.04 | sell |
| Walleye Capital LLC | 100,862 | 92,500 | -8,362 | 0.06 | 0.04 | -0.02 | sell |
| BARCLAYS PLC | 12,000 | 3,543 | -8,457 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 171,645 | 161,900 | -9,745 | 0.02 | 0.01 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 10,720 | 0 | -10,720 | 0.01 | 0.00 | -0.01 | sell |
| Marathon Trading Investment Management LLC | 12,000 | 0 | -12,000 | 0.24 | 0.00 | -0.24 | sell |
| Informed Momentum Co LLC | 12,101 | 0 | -12,101 | 0.10 | 0.00 | -0.10 | sell |
| CITIGROUP INC | 17,521 | 2,275 | -15,246 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 28,033 | 0 | -28,033 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 437,538 | 386,465 | -51,073 | 0.25 | 0.17 | -0.08 | sell |
| JANE STREET GROUP, LLC | 54,888 | 0 | -54,888 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 83,420 | 24,736 | -58,684 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 74,087 | 13,055 | -61,032 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 73,035 | 5,135 | -67,900 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 131,258 | 40,765 | -90,493 | 0.01 | 0.00 | -0.01 | sell |
| Altium Capital Management LLC | 100,000 | 0 | -100,000 | 2.27 | 0.00 | -2.27 | sell |
| MORGAN STANLEY | 516,608 | 382,668 | -133,940 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 538,714 | 107,344 | -431,370 | 1.21 | 0.23 | -0.98 | sell |