| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TORONTO DOMINION BANK | 239,261 | 681,337 | +442,076 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 286,112 | 545,603 | +259,491 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 157,937 | 307,805 | +149,868 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 441,591 | 585,397 | +143,806 | 0.08 | 0.16 | +0.07 | buy |
| JENNISON ASSOCIATES LLC | 108,084 | 167,563 | +59,479 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 52,521 | 95,401 | +42,880 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 31,711 | +31,711 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 208,716 | 240,319 | +31,603 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 30,177 | +30,177 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 26,006 | +26,006 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 21,485 | +21,485 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 470,964 | 485,859 | +14,895 | 3.00 | 4.72 | +1.72 | buy |
| RTW INVESTMENTS, LP | 1,348,656 | 1,362,456 | +13,800 | 0.24 | 0.29 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 10,570 | +10,570 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 34,421 | 44,904 | +10,483 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,844 | 20,497 | +9,653 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 462,879 | 468,476 | +5,597 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 14,229 | 18,011 | +3,782 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 27,925 | 29,625 | +1,700 | 0.06 | 0.07 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 670 | 1,916 | +1,246 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,823 | 4,055 | +1,232 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 845 | 1,711 | +866 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 83,410 | 83,835 | +425 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 829 | 1,089 | +260 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 150,862 | 151,119 | +257 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 103 | 266 | +163 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 254 | 405 | +151 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 491 | 551 | +60 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 15 | 25 | +10 | 0.00 | 0.00 | +0.00 | buy |
| TWIN PEAKS WEALTH ADVISORS, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 746 | 746 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 1,295,361 | 1,295,361 | 0 | 1.24 | 1.76 | +0.52 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 0.88 | 1.13 | +0.24 | hold |
| Rock Springs Capital Management LP | 104,339 | 104,339 | 0 | 0.07 | 0.10 | +0.03 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,717,127 | 1,717,127 | 0 | 3.59 | 5.25 | +1.66 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ATTICUS WEALTH MANAGEMENT, LLC | 437 | 437 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Octagon Capital Advisors LP | 303,000 | 303,000 | 0 | 0.48 | 0.99 | +0.51 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,071 | 2,071 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Raiffeisen Bank International AG | 30,000 | 30,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 368 | 368 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 356 | 356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,765 | 32,765 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 18 | 17 | -1 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 353 | 303 | -50 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 6,420 | 6,367 | -53 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,980 | 2,864 | -116 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 6,054 | 5,932 | -122 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 1,230 | 898 | -332 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 15,693 | 15,325 | -368 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 51,500 | 51,096 | -404 | 0.17 | 0.21 | +0.04 | sell |
| Bank of New York Mellon Corp | 24,445 | 23,762 | -683 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,253 | 45 | -1,208 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 6,609 | 5,119 | -1,490 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,983 | 5,384 | -1,599 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 7,351 | 4,609 | -2,742 | 0.02 | 0.02 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 21,176 | 17,296 | -3,880 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 33,969 | 29,959 | -4,010 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 27,482 | 22,667 | -4,815 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 8,576 | 3,575 | -5,001 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 5,826 | 0 | -5,826 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 617,935 | 610,337 | -7,598 | 0.00 | 0.00 | +0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 11,231 | 0 | -11,231 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 259,376 | 247,775 | -11,601 | 0.00 | 0.00 | +0.00 | sell |
| EntryPoint Capital, LLC | 12,666 | 0 | -12,666 | 0.07 | 0.00 | -0.07 | sell |
| CITADEL ADVISORS LLC | 16,416 | 0 | -16,416 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 110,410 | 93,171 | -17,239 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 17,552 | 0 | -17,552 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 151,180 | 133,236 | -17,944 | 0.01 | 0.01 | +0.00 | sell |
| STATE STREET CORP | 230,538 | 210,848 | -19,690 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 56,015 | 34,761 | -21,254 | 0.02 | 0.01 | -0.00 | sell |
| Redmile Group, LLC | 1,308,063 | 1,276,676 | -31,387 | 1.45 | 2.03 | +0.58 | sell |
| JPMORGAN CHASE & CO | 86,978 | 6,335 | -80,643 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 94,083 | 0 | -94,083 | 0.01 | 0.00 | -0.01 | sell |
| Deep Track Capital, LP | 116,660 | 0 | -116,660 | 0.04 | 0.00 | -0.04 | sell |
| BlackRock, Inc. | 1,399,133 | 977,682 | -421,451 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 446,880 | 0 | -446,880 | 0.10 | 0.00 | -0.10 | sell |
| BAKER BROS. ADVISORS LP | 1,486,200 | 991,691 | -494,509 | 0.19 | 0.14 | -0.05 | sell |
| Commodore Capital LP | 925,000 | 427,866 | -497,134 | 0.80 | 0.45 | -0.35 | sell |