| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FRANKLIN RESOURCES INC | 0 | 204,280 | +204,280 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 141,920 | +141,920 | 0.00 | 0.01 | +0.01 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 141,636 | +141,636 | 0.00 | 0.10 | +0.10 | buy |
| Casdin Capital, LLC | 1,420,361 | 1,545,361 | +125,000 | 2.17 | 2.43 | +0.26 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,765 | 143,528 | +110,763 | 0.00 | 0.03 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 718,389 | 818,706 | +100,317 | 0.03 | 0.05 | +0.02 | buy |
| Trexquant Investment LP | 0 | 73,762 | +73,762 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 1,005,070 | 1,057,983 | +52,913 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 32,742 | +32,742 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 56,635 | 89,032 | +32,397 | 0.26 | 0.53 | +0.27 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 31,393 | +31,393 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 27,431 | 55,424 | +27,993 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 26,089 | +26,089 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 24,320 | +24,320 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 387,031 | 408,982 | +21,951 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,415 | 32,628 | +21,213 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 279,003 | 293,182 | +14,179 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 10,581 | +10,581 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 9,781 | +9,781 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 9,460 | +9,460 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 8,896 | +8,896 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 7,800 | +7,800 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 7,491 | +7,491 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 930 | 7,868 | +6,938 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 6,658 | +6,658 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 97,621 | 103,641 | +6,020 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,268 | 9,471 | +5,203 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 18,540 | 23,330 | +4,790 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,311 | 15,061 | +4,750 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,607 | 5,472 | +3,865 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 3,721 | +3,721 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 12,606 | 16,040 | +3,434 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,570 | 13,770 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 26,043 | 28,741 | +2,698 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,058 | 32,742 | +2,684 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 25,210 | 27,824 | +2,614 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 104,339 | 106,750 | +2,411 | 0.12 | 0.16 | +0.04 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 1,432 | +1,432 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 980 | +980 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 14 | 906 | +892 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,751 | 3,310 | +559 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 106,255 | 106,660 | +405 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 63 | 463 | +400 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,892 | 14,153 | +261 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 231 | +231 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 898 | 1,098 | +200 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 30 | 147 | +117 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13,793 | 13,803 | +10 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 535 | 545 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 45 | 53 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 30 | 36 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 170 | 176 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52,300 | 52,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,781 | 18,781 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 991,691 | 991,691 | 0 | 0.11 | 0.16 | +0.04 | hold |
| RTW INVESTMENTS, LP | 1,362,456 | 1,362,456 | 0 | 0.27 | 0.37 | +0.09 | hold |
| MetLife Investment Management, LLC | 5,932 | 5,932 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.10 | 1.98 | +0.89 | hold |
| Larson Financial Group LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,717,127 | 1,717,127 | 0 | 3.36 | 4.44 | +1.07 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 83,835 | 83,835 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SBI Securities Co., Ltd. | 125 | 125 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 3,846 | 3,846 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 292 | 292 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 681,337 | 681,337 | 0 | 0.03 | 0.04 | +0.01 | hold |
| IFP Advisors, Inc | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 340 | 332 | -8 | 0.00 | 0.00 | +0.00 | sell |
| MAI Capital Management | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 44 | 27 | -17 | 0.00 | 0.00 | +0.00 | sell |
| Optiver Holding B.V. | 67 | 32 | -35 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 96 | 35 | -61 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 89 | 0 | -89 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,307 | 5,207 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 808 | 707 | -101 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 374 | 228 | -146 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,749 | 2,515 | -234 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 604 | 156 | -448 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,047 | 4,501 | -546 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,694 | 1,898 | -796 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,279 | 440 | -839 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 13,033 | 11,244 | -1,789 | 0.07 | 0.08 | +0.01 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 7,994 | 6,090 | -1,904 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 64,922 | 61,882 | -3,040 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 12,754 | 8,387 | -4,367 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 16,687 | 12,260 | -4,427 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 107,714 | 101,276 | -6,438 | 0.00 | 0.00 | +0.00 | sell |
| Raiffeisen Bank International AG | 43,000 | 34,000 | -9,000 | 0.01 | 0.01 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 527,685 | 518,582 | -9,103 | 0.01 | 0.01 | +0.00 | sell |
| NOMURA HOLDINGS INC | 12,724 | 0 | -12,724 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,891 | 0 | -13,891 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 185,679 | 171,289 | -14,390 | 0.00 | 0.00 | +0.00 | sell |
| BLAIR WILLIAM & CO/IL | 168,218 | 146,905 | -21,313 | 0.01 | 0.01 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 43,400 | 20,405 | -22,995 | 0.00 | 0.00 | -0.00 | sell |