| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 72,286 | 731,801 | +659,515 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 83,088 | +83,088 | 0.00 | 0.03 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 0 | 78,650 | +78,650 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 28,739 | 94,721 | +65,982 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 65,119 | +65,119 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,070,565 | 1,135,256 | +64,691 | 0.60 | 0.69 | +0.09 | buy |
| STATE STREET CORP | 209,853 | 246,540 | +36,687 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 13,055 | 41,165 | +28,110 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 24,736 | 43,700 | +18,964 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 14,300 | 32,666 | +18,366 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 18,290 | +18,290 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 0 | 15,000 | +15,000 | 0.00 | 0.10 | +0.10 | buy |
| BANK OF AMERICA CORP /DE/ | 27,066 | 40,578 | +13,512 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 563,525 | 576,160 | +12,635 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,543 | 14,859 | +11,316 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 8,396 | +8,396 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 7,717 | +7,717 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 7,050 | +7,050 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 6,054 | +6,054 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 5,696 | +5,696 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,275 | 7,462 | +5,187 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 4,980 | +4,980 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 4,583 | +4,583 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 3,576 | +3,576 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 332,284 | 334,368 | +2,084 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 7,100 | 8,827 | +1,727 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 3,423 | 5,124 | +1,701 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 741 | 2,170 | +1,429 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,489 | 14,378 | +889 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,576 | 30,317 | +741 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 449 | +449 | 0.00 | 0.00 | +0.00 | buy |
| ATTICUS WEALTH MANAGEMENT, LLC | 0 | 437 | +437 | 0.00 | 0.01 | +0.01 | buy |
| Truvestments Capital LLC | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,156 | 2,194 | +38 | 0.04 | 0.04 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,017 | 4,047 | +30 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 8 | 9 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 746 | 746 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 456,015 | 456,015 | 0 | 0.21 | 0.20 | -0.01 | hold |
| GREAT POINT PARTNERS LLC | 1,004,291 | 1,004,291 | 0 | 7.00 | 12.72 | +5.71 | hold |
| ArrowMark Colorado Holdings LLC | 386,465 | 386,465 | 0 | 0.17 | 0.21 | +0.04 | hold |
| Casdin Capital, LLC | 524,616 | 524,616 | 0 | 1.46 | 1.47 | +0.01 | hold |
| Cormorant Asset Management, LP | 107,344 | 107,344 | 0 | 0.23 | 0.24 | +0.01 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.42 | 1.83 | +0.41 | hold |
| Avoro Capital Advisors LLC | 22,029 | 22,029 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,267,790 | 1,267,790 | 0 | 9.66 | 10.22 | +0.57 | hold |
| Integral Health Asset Management, LLC | 70,000 | 70,000 | 0 | 0.25 | 0.35 | +0.09 | hold |
| Commodore Capital LP | 200,000 | 200,000 | 0 | 0.50 | 0.52 | +0.03 | hold |
| Farther Finance Advisors, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,022 | 1,022 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 356 | 356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 102,187 | 102,187 | 0 | 0.04 | 0.04 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 125 | 112 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 5,541 | 5,507 | -34 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 9,456 | 9,249 | -207 | 0.00 | 0.00 | +0.00 | sell |
| AlphaQuest LLC | 1,523 | 1,279 | -244 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,765 | 40,240 | -525 | 0.00 | 0.00 | +0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 6,519 | 5,956 | -563 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 1,253 | 553 | -700 | 0.01 | 0.00 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 222,062 | 220,599 | -1,463 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 11,000 | 7,775 | -3,225 | 0.10 | 0.08 | -0.02 | sell |
| Qube Research & Technologies Ltd | 5,135 | 0 | -5,135 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 78,601 | 73,299 | -5,302 | 0.84 | 0.92 | +0.08 | sell |
| Bank of New York Mellon Corp | 30,428 | 22,670 | -7,758 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 133,694 | 121,837 | -11,857 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 382,668 | 356,425 | -26,243 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 52,807 | 22,807 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 72,279 | 42,279 | -30,000 | 0.26 | 0.15 | -0.11 | sell |
| MARSHALL WACE, LLP | 41,447 | 9,980 | -31,467 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 92,500 | 44,500 | -48,000 | 0.04 | 0.02 | -0.02 | sell |
| Redmile Group, LLC | 1,013,663 | 964,347 | -49,316 | 2.23 | 2.38 | +0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 161,900 | 41,900 | -120,000 | 0.01 | 0.00 | -0.01 | sell |
| JANUS HENDERSON GROUP PLC | 834,791 | 709,469 | -125,322 | 0.02 | 0.02 | -0.00 | sell |
| Avidity Partners Management LP | 727,537 | 425,041 | -302,496 | 1.12 | 0.91 | -0.22 | sell |