| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 699,002 | +699,002 | 0.00 | 0.02 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 167,563 | 394,089 | +226,526 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 62,407 | +62,407 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 17,296 | 72,802 | +55,506 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 39,483 | +39,483 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 32,521 | +32,521 | 0.00 | 0.01 | +0.01 | buy |
| Redmile Group, LLC | 1,276,676 | 1,299,022 | +22,346 | 2.03 | 2.19 | +0.16 | buy |
| Quadrature Capital Ltd | 0 | 16,828 | +16,828 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 13,631 | +13,631 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 12,878 | +12,878 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 12,000 | +12,000 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 5,119 | 16,454 | +11,335 | 0.01 | 0.02 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 10,781 | +10,781 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 585,397 | 595,839 | +10,442 | 0.16 | 0.19 | +0.03 | buy |
| BLAIR WILLIAM & CO/IL | 133,236 | 141,820 | +8,584 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 7,669 | +7,669 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 30,000 | 34,000 | +4,000 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 2,262 | +2,262 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,367 | 7,599 | +1,232 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 151,119 | 152,284 | +1,165 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,071 | 3,141 | +1,070 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 29,625 | 30,633 | +1,008 | 0.07 | 0.05 | -0.02 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,055 | 5,055 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,089 | 2,067 | +978 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 4,609 | 5,578 | +969 | 0.02 | 0.03 | +0.00 | buy |
| Bank of New York Mellon Corp | 23,762 | 24,651 | +889 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 835 | +835 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 41 | 856 | +815 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 597 | +597 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 266 | 679 | +413 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 303 | 517 | +214 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 20,497 | 20,551 | +54 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 17 | 44 | +27 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 152 | 174 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 25 | 27 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 551 | 552 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 30,177 | 30,177 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 10,570 | 10,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 991,691 | 991,691 | 0 | 0.14 | 0.12 | -0.02 | hold |
| RTW INVESTMENTS, LP | 1,362,456 | 1,362,456 | 0 | 0.29 | 0.29 | +0.00 | hold |
| MetLife Investment Management, LLC | 5,932 | 5,932 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Casdin Capital, LLC | 1,295,361 | 1,295,361 | 0 | 1.76 | 1.87 | +0.11 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.13 | 1.06 | -0.07 | hold |
| Rock Springs Capital Management LP | 104,339 | 104,339 | 0 | 0.10 | 0.11 | +0.01 | hold |
| Versant Capital Management, Inc | 33 | 33 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,717,127 | 1,717,127 | 0 | 5.25 | 3.89 | -1.37 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 83,835 | 83,835 | 0 | 0.01 | 0.01 | +0.00 | hold |
| US BANCORP \DE\ | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 898 | 898 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,959 | 29,959 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 356 | 356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,765 | 32,765 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 681,337 | 681,337 | 0 | 0.02 | 0.02 | +0.00 | hold |
| TWIN PEAKS WEALTH ADVISORS, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 55 | 40 | -15 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 368 | 316 | -52 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 746 | 617 | -129 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 15,325 | 15,059 | -266 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,864 | 2,502 | -362 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 405 | 0 | -405 | 0.00 | 0.00 | -0.00 | sell |
| ATTICUS WEALTH MANAGEMENT, LLC | 437 | 0 | -437 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,711 | 1,234 | -477 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,916 | 1,167 | -749 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,384 | 4,625 | -759 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 6,335 | 5,563 | -772 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 247,775 | 246,433 | -1,342 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 22,667 | 21,093 | -1,574 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 210,848 | 208,310 | -2,538 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 93,171 | 90,098 | -3,073 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 18,011 | 14,927 | -3,084 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 3,575 | 389 | -3,186 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 610,337 | 604,611 | -5,726 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 240,319 | 227,716 | -12,603 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 51,096 | 30,375 | -20,721 | 0.21 | 0.13 | -0.08 | sell |
| HRT FINANCIAL LP | 21,485 | 0 | -21,485 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,006 | 0 | -26,006 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 977,682 | 951,100 | -26,582 | 0.00 | 0.00 | +0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 31,711 | 0 | -31,711 | 0.02 | 0.00 | -0.02 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 34,761 | 0 | -34,761 | 0.01 | 0.00 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 485,859 | 446,814 | -39,045 | 4.72 | 3.23 | -1.49 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 44,904 | 0 | -44,904 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 303,000 | 252,000 | -51,000 | 0.99 | 0.68 | -0.31 | sell |
| BANK OF AMERICA CORP /DE/ | 95,401 | 40,553 | -54,848 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 307,805 | 247,864 | -59,941 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 545,603 | 426,576 | -119,027 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 468,476 | 115,550 | -352,926 | 0.00 | 0.00 | -0.00 | sell |
| Commodore Capital LP | 427,866 | 0 | -427,866 | 0.45 | 0.00 | -0.45 | sell |