| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 1,271,342 | +1,271,342 | 0.00 | 0.64 | +0.64 | buy |
| Samsara BioCapital, LLC | 0 | 1,267,790 | +1,267,790 | 0.00 | 3.82 | +3.82 | buy |
| GREAT POINT PARTNERS LLC | 0 | 994,229 | +994,229 | 0.00 | 3.28 | +3.28 | buy |
| Redmile Group, LLC | 0 | 946,897 | +946,897 | 0.00 | 0.66 | +0.66 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 841,688 | +841,688 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 0 | 746,180 | +746,180 | 0.00 | 0.69 | +0.69 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 525,529 | +525,529 | 0.00 | 0.11 | +0.11 | buy |
| Casdin Capital, LLC | 0 | 524,616 | +524,616 | 0.00 | 1.00 | +1.00 | buy |
| Avidity Partners Management LP | 0 | 466,243 | +466,243 | 0.00 | 0.35 | +0.35 | buy |
| BAKER BROS. ADVISORS LP | 0 | 453,516 | +453,516 | 0.00 | 0.10 | +0.10 | buy |
| MORGAN STANLEY | 0 | 339,979 | +339,979 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 188,501 | +188,501 | 0.00 | 0.05 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 135,581 | +135,581 | 0.00 | 0.01 | +0.01 | buy |
| Nantahala Capital Management, LLC | 0 | 72,279 | +72,279 | 0.00 | 0.14 | +0.14 | buy |
| Altium Capital Management LLC | 0 | 66,981 | +66,981 | 0.00 | 0.89 | +0.89 | buy |
| VANGUARD GROUP INC | 0 | 50,421 | +50,421 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 50,194 | +50,194 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 49,729 | +49,729 | 0.00 | 0.00 | +0.00 | buy |
| BML Capital Management, LLC | 0 | 24,666 | +24,666 | 0.00 | 0.38 | +0.38 | buy |
| ExodusPoint Capital Management, LP | 0 | 20,306 | +20,306 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 15,719 | +15,719 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 3,467 | +3,467 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |