| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Samsara BioCapital, LLC | 1,267,790 | 1,717,127 | +449,337 | 10.22 | 5.39 | -4.84 | buy |
| BlackRock, Inc. | 1,371,879 | 1,516,157 | +144,278 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 1,135,256 | 1,350,256 | +215,000 | 0.69 | 0.47 | -0.22 | buy |
| Redmile Group, LLC | 964,347 | 1,319,763 | +355,416 | 2.38 | 2.10 | -0.28 | buy |
| Casdin Capital, LLC | 524,616 | 1,295,361 | +770,745 | 1.47 | 1.98 | +0.51 | buy |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.83 | 1.16 | -0.67 | hold |
| FMR LLC | 731,801 | 860,333 | +128,532 | 0.00 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 200,000 | 800,000 | +600,000 | 0.52 | 1.34 | +0.82 | buy |
| BAKER BROS. ADVISORS LP | 456,015 | 674,450 | +218,435 | 0.20 | 0.16 | -0.03 | buy |
| VANGUARD GROUP INC | 576,160 | 568,016 | -8,144 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 4,583 | 481,001 | +476,418 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 386,465 | 448,601 | +62,136 | 0.21 | 0.14 | -0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 448,145 | +448,145 | 0.00 | 0.19 | +0.19 | buy |
| GREAT POINT PARTNERS LLC | 1,004,291 | 442,761 | -561,530 | 12.72 | 4.77 | -7.95 | sell |
| UBS Group AG | 5,124 | 347,201 | +342,077 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 356,425 | 329,863 | -26,562 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 15,000 | 303,000 | +288,000 | 0.10 | 1.18 | +1.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 220,599 | 234,625 | +14,026 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 246,540 | 225,373 | -21,167 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 334,368 | 152,371 | -181,997 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 123,291 | +123,291 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 94,721 | 100,566 | +5,845 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 0 | 95,407 | +95,407 | 0.00 | 0.08 | +0.08 | buy |
| Woodline Partners LP | 83,088 | 83,340 | +252 | 0.03 | 0.01 | -0.02 | buy |
| Vestal Point Capital, LP | 0 | 80,000 | +80,000 | 0.00 | 0.11 | +0.11 | buy |
| Walleye Capital LLC | 44,500 | 74,836 | +30,336 | 0.02 | 0.02 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,240 | 74,778 | +34,538 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 78,650 | 72,596 | -6,054 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 0 | 62,640 | +62,640 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 7,775 | 51,500 | +43,725 | 0.08 | 0.30 | +0.22 | buy |
| GOLDMAN SACHS GROUP INC | 41,165 | 38,058 | -3,107 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 102,187 | 32,765 | -69,422 | 0.04 | 0.01 | -0.03 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 8,827 | 32,734 | +23,907 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,317 | 30,317 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 40,578 | 26,507 | -14,071 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 22,670 | 22,601 | -69 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 18,290 | 21,717 | +3,427 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 20,629 | +20,629 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 14,859 | 17,533 | +2,674 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 4,980 | 17,431 | +12,451 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 15,800 | +15,800 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 14,378 | 15,704 | +1,326 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 15,256 | +15,256 | 0.00 | 0.03 | +0.03 | buy |
| M&T BANK CORP | 0 | 14,138 | +14,138 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 14,079 | +14,079 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,936 | +10,936 | 0.00 | 0.02 | +0.02 | buy |
| Mariner, LLC | 0 | 10,475 | +10,475 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 5,956 | 10,290 | +4,334 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 9,933 | +9,933 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 32,666 | 9,189 | -23,477 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 7,462 | 8,100 | +638 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 6,054 | 6,054 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,696 | 5,924 | +228 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,047 | 5,444 | +1,397 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 5,507 | 5,121 | -386 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIRTUS ADVISERS, LLC | 2,194 | 3,183 | +989 | 0.04 | 0.03 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 3,150 | +3,150 | 0.00 | 0.01 | +0.01 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 3,126 | +3,126 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,170 | 1,380 | -790 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,022 | 1,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 746 | 746 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 8,396 | 629 | -7,767 | 0.01 | 0.00 | -0.01 | sell |
| Mirae Asset Global Investments Co., Ltd. | 0 | 495 | +495 | 0.00 | 0.00 | +0.00 | buy |
| ATTICUS WEALTH MANAGEMENT, LLC | 437 | 437 | 0 | 0.01 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 356 | 356 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 22 | 171 | +149 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 132 | +132 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 112 | 43 | -69 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CoreCap Advisors, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 2 | +2 | 0.00 | 0.00 | 0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 22,807 | 0 | -22,807 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 65,119 | 0 | -65,119 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 41,900 | 0 | -41,900 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 43,700 | 0 | -43,700 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 709,469 | 0 | -709,469 | 0.02 | 0.00 | -0.02 | sell |
| SG Americas Securities, LLC | 3,576 | 0 | -3,576 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 9,980 | 0 | -9,980 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 42,279 | 0 | -42,279 | 0.15 | 0.00 | -0.15 | sell |
| Cormorant Asset Management, LP | 107,344 | 0 | -107,344 | 0.24 | 0.00 | -0.24 | sell |
| JANE STREET GROUP, LLC | 7,717 | 0 | -7,717 | 0.00 | 0.00 | -0.00 | sell |
| Avoro Capital Advisors LLC | 22,029 | 0 | -22,029 | 0.01 | 0.00 | -0.01 | sell |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Integral Health Asset Management, LLC | 70,000 | 0 | -70,000 | 0.35 | 0.00 | -0.35 | sell |
| Avidity Partners Management LP | 425,041 | 0 | -425,041 | 0.91 | 0.00 | -0.91 | sell |
| AlphaQuest LLC | 1,279 | 0 | -1,279 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 553 | 0 | -553 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 73,299 | 0 | -73,299 | 0.92 | 0.00 | -0.92 | sell |
| Siren, L.L.C. | 175,898 | 0 | -175,898 | 0.37 | 0.00 | -0.37 | sell |
| Smartleaf Asset Management LLC | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 7,050 | 0 | -7,050 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 9,249 | 0 | -9,249 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |