| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 524,616 | 1,295,361 | +770,745 | 1.47 | 1.97 | +0.50 | buy |
| Commodore Capital LP | 200,000 | 800,000 | +600,000 | 0.52 | 1.34 | +0.82 | buy |
| Samsara BioCapital, LLC | 1,267,790 | 1,717,127 | +449,337 | 10.22 | 5.39 | -4.84 | buy |
| Redmile Group, LLC | 964,347 | 1,319,763 | +355,416 | 2.38 | 2.10 | -0.28 | buy |
| Octagon Capital Advisors LP | 15,000 | 303,000 | +288,000 | 0.10 | 1.18 | +1.08 | buy |
| BAKER BROS. ADVISORS LP | 456,015 | 674,450 | +218,435 | 0.20 | 0.16 | -0.03 | buy |
| RTW INVESTMENTS, LP | 1,135,256 | 1,350,256 | +215,000 | 0.69 | 0.47 | -0.22 | buy |
| ArrowMark Colorado Holdings LLC | 386,465 | 448,601 | +62,136 | 0.21 | 0.14 | -0.07 | buy |
| DAFNA Capital Management LLC | 7,775 | 51,500 | +43,725 | 0.08 | 0.30 | +0.22 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 8,827 | 32,734 | +23,907 | 0.03 | 0.06 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,194 | 3,183 | +989 | 0.04 | 0.03 | -0.01 | buy |
| Woodline Partners LP | 83,088 | 83,340 | +252 | 0.03 | 0.01 | -0.02 | buy |
| JENNISON ASSOCIATES LLC | 78,650 | 72,596 | -6,054 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 102,187 | 32,765 | -69,422 | 0.04 | 0.01 | -0.03 | sell |
| GREAT POINT PARTNERS LLC | 1,004,291 | 442,761 | -561,530 | 12.40 | 4.77 | -7.63 | sell |