| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 0 | 364,228 | +364,228 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 195,000 | +195,000 | 0.00 | 0.27 | +0.27 | buy |
| Redmile Group, LLC | 1,299,022 | 1,459,599 | +160,577 | 2.19 | 2.21 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 394,089 | 533,088 | +138,999 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 208,310 | 307,797 | +99,487 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 72,802 | 162,018 | +89,216 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 604,611 | 656,572 | +51,961 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 40,347 | +40,347 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 36,102 | +36,102 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 32,489 | +32,489 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 27,894 | +27,894 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 30,177 | 52,300 | +22,123 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 141,820 | 163,655 | +21,835 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 115,550 | 130,329 | +14,779 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 14,530 | +14,530 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 12,721 | +12,721 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 11,410 | +11,410 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 8,192 | +8,192 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 34,000 | 42,000 | +8,000 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 5,578 | 12,716 | +7,138 | 0.03 | 0.07 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 13,631 | 17,560 | +3,929 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 39,483 | 43,323 | +3,840 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,599 | 11,037 | +3,438 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 246,433 | 249,695 | +3,262 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 3,227 | +3,227 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 40,553 | 41,759 | +1,206 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 14,927 | 15,375 | +448 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 389 | 754 | +365 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,067 | 2,424 | +357 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 552 | 753 | +201 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 11 | 163 | +152 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,055 | 5,124 | +69 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,167 | 1,233 | +66 | 0.00 | 0.00 | +0.00 | buy |
| SageView Advisory Group, LLC | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,502 | 2,524 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,009 | 1,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,781 | 10,781 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 10,570 | 10,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 991,691 | 991,691 | 0 | 0.12 | 0.12 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,362,456 | 1,362,456 | 0 | 0.29 | 0.28 | -0.01 | hold |
| MetLife Investment Management, LLC | 5,932 | 5,932 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 1,295,361 | 1,295,361 | 0 | 1.87 | 1.66 | -0.21 | hold |
| EcoR1 Capital, LLC | 1,271,342 | 1,271,342 | 0 | 1.06 | 1.20 | +0.14 | hold |
| Rock Springs Capital Management LP | 104,339 | 104,339 | 0 | 0.11 | 0.11 | +0.00 | hold |
| Russell Investments Group, Ltd. | 856 | 856 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 44 | 44 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 33 | 33 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,717,127 | 1,717,127 | 0 | 3.89 | 3.65 | -0.24 | hold |
| Truvestments Capital LLC | 46 | 46 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 83,835 | 83,835 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Nuveen, LLC | 21,093 | 21,093 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 30,633 | 30,633 | 0 | 0.05 | 0.05 | -0.01 | hold |
| Legal & General Group Plc | 898 | 898 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 4,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 40 | 40 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,959 | 29,959 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 45 | 45 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,765 | 32,765 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 681,337 | 681,337 | 0 | 0.02 | 0.02 | +0.00 | hold |
| SBI Securities Co., Ltd. | 27 | 25 | -2 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 617 | 606 | -11 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 16 | 2 | -14 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 316 | 302 | -14 | 0.00 | 0.00 | +0.00 | sell |
| Optiver Holding B.V. | 76 | 61 | -15 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 174 | 154 | -20 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,625 | 4,591 | -34 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 356 | 309 | -47 | 0.00 | 0.00 | +0.00 | sell |
| BESSEMER GROUP INC | 87 | 0 | -87 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 517 | 408 | -109 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 679 | 567 | -112 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 5,563 | 5,363 | -200 | 0.00 | 0.00 | +0.00 | sell |
| Farther Finance Advisors, LLC | 597 | 0 | -597 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 3,141 | 2,013 | -1,128 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,234 | 62 | -1,172 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 24,651 | 23,093 | -1,558 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 15,059 | 13,383 | -1,676 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 30,375 | 27,974 | -2,401 | 0.13 | 0.13 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 32,521 | 29,119 | -3,402 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 90,098 | 85,559 | -4,539 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 951,100 | 945,583 | -5,517 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 7,669 | 0 | -7,669 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 20,551 | 11,991 | -8,560 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 16,454 | 7,215 | -9,239 | 0.02 | 0.01 | -0.01 | sell |
| XTX Topco Ltd | 12,000 | 0 | -12,000 | 0.01 | 0.00 | -0.01 | sell |
| Brevan Howard Capital Management LP | 12,878 | 0 | -12,878 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 16,828 | 0 | -16,828 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 595,839 | 577,490 | -18,349 | 0.19 | 0.26 | +0.07 | sell |
| JANE STREET GROUP, LLC | 62,407 | 15,105 | -47,302 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 426,576 | 371,174 | -55,402 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 152,284 | 85,571 | -66,713 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 227,716 | 154,123 | -73,593 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 699,002 | 608,578 | -90,424 | 0.02 | 0.02 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 446,814 | 350,000 | -96,814 | 3.23 | 2.34 | -0.90 | sell |
| MILLENNIUM MANAGEMENT LLC | 247,864 | 71,321 | -176,543 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 252,000 | 0 | -252,000 | 0.68 | 0.00 | -0.68 | sell |