| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MARSHALL WACE, LLP | 425,028 | 1,656,821 | +1,231,793 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 666,551 | 1,514,461 | +847,910 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 408,492 | 1,093,230 | +684,738 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 662,666 | +662,666 | 0.00 | 1.06 | +1.06 | buy |
| Point72 Asset Management, L.P. | 0 | 482,355 | +482,355 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 256,772 | 643,300 | +386,528 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 234,041 | 619,592 | +385,551 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 249,344 | +249,344 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 225,000 | +225,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 221,951 | +221,951 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 7,022 | 195,099 | +188,077 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 176,200 | +176,200 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 78,747 | 236,138 | +157,391 | 0.01 | 0.04 | +0.03 | buy |
| Graham Capital Management, L.P. | 0 | 133,620 | +133,620 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 100,100 | +100,100 | 0.00 | 0.02 | +0.02 | buy |
| TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.13 | +0.13 | buy |
| SG Americas Securities, LLC | 0 | 97,375 | +97,375 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 658,553 | 755,000 | +96,447 | 7.48 | 7.89 | +0.41 | buy |
| UBS Group AG | 397,534 | 491,868 | +94,334 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 59,053 | +59,053 | 0.00 | 0.00 | +0.00 | buy |
| Aptus Capital Advisors, LLC | 210,200 | 263,200 | +53,000 | 0.00 | 0.00 | +0.00 | buy |
| GUARDIAN WEALTH ADVISORS, LLC / NC | 210,200 | 263,200 | +53,000 | 0.03 | 0.03 | +0.01 | buy |
| October Effect Ltd | 0 | 52,100 | +52,100 | 0.00 | 0.12 | +0.12 | buy |
| Qube Research & Technologies Ltd | 0 | 34,596 | +34,596 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 12,698 | 47,140 | +34,442 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 30,124 | +30,124 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 7,812 | 33,858 | +26,046 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 21,893 | +21,893 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 20,722 | +20,722 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 18,990 | +18,990 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 17,215 | +17,215 | 0.00 | 0.08 | +0.08 | buy |
| Pathstone Holdings, LLC | 1,000,000 | 1,017,040 | +17,040 | 0.01 | 0.01 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Eaton Financial Holdings Company, LLC | 0 | 12,750 | +12,750 | 0.00 | 0.01 | +0.01 | buy |
| Strategic Family Wealth Counselors, L.L.C. | 0 | 12,675 | +12,675 | 0.00 | 0.01 | +0.01 | buy |
| Bay Rivers Group | 16,691 | 28,861 | +12,170 | 0.01 | 0.02 | +0.01 | buy |
| Bronte Capital Management Pty Ltd. | 0 | 10,414 | +10,414 | 0.00 | 0.00 | +0.00 | buy |
| INTEGRAL INVESTMENT ADVISORS, INC. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 10,000 | 20,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 8,980 | +8,980 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 11,000 | 16,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 401,559 | 402,635 | +1,076 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 1,077 | 1,591 | +514 | 0.00 | 0.00 | +0.00 | buy |
| Rialto Wealth Management, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Cascades Capital Asset Management, LLC | 77,335 | 77,510 | +175 | 0.07 | 0.07 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 74,022 | 74,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ancora Advisors LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 2,506,102 | 2,506,102 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Creative Planning | 23,410 | 23,410 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Focus Partners Wealth | 36,000 | 36,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Beta Wealth Group, Inc. | 14,127 | 14,127 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Valeo Financial Advisors, LLC | 130,699 | 130,699 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Secure Asset Management, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Safeguard Investment Advisory Group, LLC | 25,044 | 25,044 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SBI Securities Co., Ltd. | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Stephenson & Company, Inc. | 20,000 | 20,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Taylor Financial Group, Inc. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Boxer Capital Management, LLC | 666,666 | 666,666 | 0 | 0.42 | 0.29 | -0.13 | hold |
| Federation des caisses Desjardins du Quebec | 29,781 | 29,781 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 3,200 | 3,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 26,600 | 26,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 39,258 | 39,258 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 18,700 | 18,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TORONTO DOMINION BANK | 750,000 | 750,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 22,220 | 21,875 | -345 | 0.00 | 0.00 | -0.00 | sell |
| Wealthspire Advisors, LLC | 1,129 | 0 | -1,129 | 0.00 | 0.00 | -0.00 | sell |
| SAPIENT CAPITAL LLC | 12,200 | 0 | -12,200 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 187,301 | 171,960 | -15,341 | 0.02 | 0.01 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 66,920 | 0 | -66,920 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 138,812 | 0 | -138,812 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 143,400 | 0 | -143,400 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 512,067 | 353,232 | -158,835 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 223,470 | 0 | -223,470 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 356,567 | 0 | -356,567 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 666,666 | 0 | -666,666 | 0.12 | 0.00 | -0.12 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 820,000 | 0 | -820,000 | 0.39 | 0.00 | -0.39 | sell |
| Propel Bio Management, LLC | 5,124,890 | 4,118,321 | -1,006,569 | 10.26 | 7.10 | -3.16 | sell |
| Simplify Asset Management Inc. | 2,832,974 | 1,506,405 | -1,326,569 | 0.11 | 0.05 | -0.06 | sell |
| MORGAN STANLEY | 2,969,067 | 781,875 | -2,187,192 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 3,221,828 | 0 | -3,221,828 | 0.15 | 0.00 | -0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,976,000 | 2,810,037 | -4,165,963 | 0.02 | 0.01 | -0.01 | sell |