| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 288,885 | +288,885 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 109,800 | +109,800 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 1,790,182 | 1,848,582 | +58,400 | 2.36 | 2.48 | +0.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 36,498 | +36,498 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 49,508 | 83,708 | +34,200 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 32,291 | +32,291 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 20,331 | +20,331 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 18,443 | +18,443 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 54,311 | 72,071 | +17,760 | 0.07 | 0.06 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 274,472 | 279,482 | +5,010 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 163,788 | 166,164 | +2,376 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 10,466 | 11,660 | +1,194 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 48,839 | 50,018 | +1,179 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 743,495 | 743,920 | +425 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 81 | +81 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,000,000 | 2,000,000 | 0 | 0.26 | 0.29 | +0.03 | hold |
| GREAT POINT PARTNERS LLC | 1,858,735 | 1,858,735 | 0 | 1.63 | 1.53 | -0.10 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 808,550 | 808,550 | 0 | 0.77 | 0.69 | -0.08 | hold |
| BML Capital Management, LLC | 150,000 | 150,000 | 0 | 0.61 | 0.53 | -0.08 | hold |
| BFSG, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GPS Wealth Strategies Group, LLC | 8,441 | 8,441 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Commodore Capital LP | 1,575,000 | 1,575,000 | 0 | 0.71 | 0.56 | -0.15 | hold |
| TCG Crossover Management, LLC | 2,676,580 | 2,676,580 | 0 | 1.53 | 1.12 | -0.41 | hold |
| Fairman Group, LLC | 29 | 29 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 23,077 | 23,077 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,302 | 23,302 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 2,449 | 2,416 | -33 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 88 | 0 | -88 | 0.00 | 0.00 | -0.00 | sell |
| FIRST MANHATTAN CO. LLC. | 333 | 0 | -333 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,298 | 3,444 | -5,854 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 12,371 | 0 | -12,371 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 15,171 | 0 | -15,171 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 15,524 | 0 | -15,524 | 0.01 | 0.00 | -0.01 | sell |
| BLAIR WILLIAM & CO/IL | 88,046 | 68,466 | -19,580 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 58,377 | 34,906 | -23,471 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,834,512 | 1,793,166 | -41,346 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 41,886 | 0 | -41,886 | 0.05 | 0.00 | -0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 192,059 | 144,386 | -47,673 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 96,900 | 0 | -96,900 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 478,000 | 364,000 | -114,000 | 0.07 | 0.05 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 245,502 | 89,938 | -155,564 | 0.56 | 0.13 | -0.43 | sell |
| Nantahala Capital Management, LLC | 1,816,730 | 1,517,696 | -299,034 | 0.93 | 0.79 | -0.15 | sell |