| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BLAIR WILLIAM & CO/IL | 68,466 | 88,466 | +20,000 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 17,107 | +17,107 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 15,488 | +15,488 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 11,395 | +11,395 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 279,482 | 290,094 | +10,612 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 20,331 | 30,315 | +9,984 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 166,164 | 174,982 | +8,818 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 83,708 | 88,708 | +5,000 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 0 | 4,146 | +4,146 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 492 | +492 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,793,166 | 1,793,166 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 2,000,000 | 2,000,000 | 0 | 0.29 | 0.20 | -0.10 | hold |
| Nantahala Capital Management, LLC | 1,517,696 | 1,517,696 | 0 | 0.79 | 0.53 | -0.25 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 808,550 | 808,550 | 0 | 0.69 | 0.46 | -0.23 | hold |
| CWM, LLC | 2,416 | 2,416 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BML Capital Management, LLC | 150,000 | 150,000 | 0 | 0.53 | 0.38 | -0.15 | hold |
| BFSG, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Commodore Capital LP | 1,575,000 | 1,575,000 | 0 | 0.56 | 0.37 | -0.18 | hold |
| TCG Crossover Management, LLC | 2,676,580 | 2,676,580 | 0 | 1.12 | 0.97 | -0.15 | hold |
| STEMPOINT CAPITAL LP | 1,848,582 | 1,848,582 | 0 | 2.48 | 1.72 | -0.76 | hold |
| Farther Finance Advisors, LLC | 81 | 81 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fairman Group, LLC | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,302 | 23,302 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 50,018 | 49,962 | -56 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 11,660 | 11,026 | -634 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,444 | 2,484 | -960 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 23,077 | 19,261 | -3,816 | 0.00 | 0.00 | -0.00 | sell |
| GPS Wealth Strategies Group, LLC | 8,441 | 0 | -8,441 | 0.01 | 0.00 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 18,443 | 0 | -18,443 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorShares Investments LLC | 72,071 | 51,780 | -20,291 | 0.06 | 0.03 | -0.03 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 32,291 | 0 | -32,291 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 34,906 | 3 | -34,903 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 36,498 | 0 | -36,498 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 109,800 | 64,900 | -44,900 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 364,000 | 300,000 | -64,000 | 0.05 | 0.03 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 144,386 | 67,511 | -76,875 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 89,938 | 0 | -89,938 | 0.13 | 0.00 | -0.13 | sell |
| CITADEL ADVISORS LLC | 743,920 | 629,645 | -114,275 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 288,885 | 65,107 | -223,778 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 1,858,735 | 1,529,338 | -329,397 | 1.53 | 1.02 | -0.51 | sell |