| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 2,676,580 | +2,676,580 | 0.00 | 0.68 | +0.68 | buy |
| ADAR1 Capital Management, LLC | 0 | 163,078 | +163,078 | 0.00 | 0.08 | +0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 64,900 | 190,600 | +125,700 | 0.00 | 0.00 | +0.00 | buy |
| Valence8 US LP | 0 | 34,376 | +34,376 | 0.00 | 0.05 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 25,337 | +25,337 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 20,828 | +20,828 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 20,033 | +20,033 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 11,395 | 27,575 | +16,180 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 51,780 | 67,780 | +16,000 | 0.03 | 0.04 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 17,107 | 23,000 | +5,893 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 15,488 | 20,210 | +4,722 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 4,460 | +4,460 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 174,982 | 176,261 | +1,279 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 3 | 1,229 | +1,226 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,793,166 | 1,793,166 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 2,000,000 | 2,000,000 | 0 | 0.20 | 0.18 | -0.02 | hold |
| Nantahala Capital Management, LLC | 1,517,696 | 1,517,696 | 0 | 0.53 | 0.38 | -0.15 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 808,550 | 808,550 | 0 | 0.46 | 0.40 | -0.06 | hold |
| CWM, LLC | 2,416 | 2,416 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BML Capital Management, LLC | 150,000 | 150,000 | 0 | 0.38 | 0.27 | -0.12 | hold |
| BFSG, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Commodore Capital LP | 1,575,000 | 1,575,000 | 0 | 0.37 | 0.30 | -0.08 | hold |
| SJS Investment Consulting Inc. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 81 | 81 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fairman Group, LLC | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,302 | 23,302 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BLAIR WILLIAM & CO/IL | 88,466 | 88,466 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 88,708 | 88,708 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 30,315 | 30,197 | -118 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,484 | 2,259 | -225 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 492 | 0 | -492 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 49,962 | 49,431 | -531 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 1,848,582 | 1,846,792 | -1,790 | 1.72 | 1.47 | -0.25 | sell |
| FMR LLC | 4,146 | 0 | -4,146 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 67,511 | 61,542 | -5,969 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 11,026 | 0 | -11,026 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,107 | 52,094 | -13,013 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 19,261 | 0 | -19,261 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 290,094 | 258,524 | -31,570 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 300,000 | 0 | -300,000 | 0.03 | 0.00 | -0.03 | sell |
| CITADEL ADVISORS LLC | 629,645 | 321,885 | -307,760 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 1,529,338 | 674,075 | -855,263 | 1.02 | 0.61 | -0.41 | sell |
| TCG Crossover Management, LLC | 2,676,580 | 0 | -2,676,580 | 0.97 | 0.00 | -0.97 | sell |