| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 4,165,767 | +4,165,767 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 3,060,000 | +3,060,000 | 0.00 | 0.26 | +0.26 | buy |
| TCG Crossover Management, LLC | 2,676,580 | 2,676,580 | 0 | 0.61 | 0.47 | -0.14 | hold |
| STEMPOINT CAPITAL LP | 2,413,254 | 2,488,685 | +75,431 | 1.33 | 1.56 | +0.24 | buy |
| Nantahala Capital Management, LLC | 1,978,492 | 1,978,492 | 0 | 0.28 | 0.43 | +0.15 | hold |
| VANGUARD GROUP INC | 1,759,642 | 1,687,735 | -71,907 | 0.00 | 0.00 | +0.00 | sell |
| Commodore Capital LP | 1,575,000 | 1,575,000 | 0 | 0.22 | 0.27 | +0.05 | hold |
| Ikarian Capital, LLC | 601,703 | 620,869 | +19,166 | 0.40 | 0.45 | +0.05 | buy |
| Soleus Capital Management, L.P. | 0 | 550,000 | +550,000 | 0.00 | 0.10 | +0.10 | buy |
| BlackRock, Inc. | 416,889 | 423,128 | +6,239 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 40,500 | 422,012 | +381,512 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 403,922 | 349,789 | -54,133 | 0.50 | 0.86 | +0.36 | sell |
| JANE STREET GROUP, LLC | 95,051 | 302,683 | +207,632 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 272,907 | 298,280 | +25,373 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 89,451 | 289,409 | +199,958 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 748,862 | 271,825 | -477,037 | 0.00 | 0.00 | -0.00 | sell |
| Almitas Capital LLC | 261,399 | 261,399 | 0 | 0.13 | 0.21 | +0.08 | hold |
| AdvisorShares Investments LLC | 203,114 | 206,998 | +3,884 | 0.07 | 0.12 | +0.05 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 177,858 | 197,024 | +19,166 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 25,832 | 157,032 | +131,200 | 0.00 | 0.00 | +0.00 | buy |
| BML Capital Management, LLC | 150,000 | 150,000 | 0 | 0.23 | 0.49 | +0.26 | hold |
| CITADEL ADVISORS LLC | 0 | 122,062 | +122,062 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 420,765 | 113,062 | -307,703 | 0.14 | 0.04 | -0.10 | sell |
| STATE STREET CORP | 96,858 | 96,858 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 85,594 | +85,594 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 86,819 | 75,319 | -11,500 | 0.15 | 0.19 | +0.04 | sell |
| XTX Topco Ltd | 0 | 69,712 | +69,712 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 43,362 | 68,017 | +24,655 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 67,770 | +67,770 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 60,152 | +60,152 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 48,093 | 48,093 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cubist Systematic Strategies, LLC | 0 | 43,953 | +43,953 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 42,704 | +42,704 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 31,063 | 41,072 | +10,009 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 31,486 | +31,486 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 7,142 | 28,928 | +21,786 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,302 | 23,302 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighTower Advisors, LLC | 20,828 | 20,828 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 0 | 20,676 | +20,676 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 20,033 | 20,033 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quadrature Capital Ltd | 0 | 15,752 | +15,752 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 85,866 | 12,573 | -73,293 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 10,883 | +10,883 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 7,155 | 8,655 | +1,500 | 0.00 | 0.01 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 6,000 | +6,000 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 3,539 | 3,453 | -86 | 0.00 | 0.00 | +0.00 | sell |
| Performa Ltd (US), LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 526 | 526 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 288 | 290 | +2 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 114 | 114 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 478 | 56 | -422 | 0.00 | 0.00 | -0.00 | sell |
| Fairman Group, LLC | 29 | 29 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 34,638 | 0 | -34,638 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 22,536 | 0 | -22,536 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 447,939 | 0 | -447,939 | 0.23 | 0.00 | -0.23 | sell |
| Tower Research Capital LLC (TRC) | 7,721 | 0 | -7,721 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 22,946 | 0 | -22,946 | 0.00 | 0.00 | -0.00 | sell |