| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 2,676,580 | +2,676,580 | 0.00 | 1.53 | +1.53 | buy |
| BVF INC/IL | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.26 | +0.26 | buy |
| GREAT POINT PARTNERS LLC | 0 | 1,858,735 | +1,858,735 | 0.00 | 1.63 | +1.63 | buy |
| Nantahala Capital Management, LLC | 0 | 1,816,730 | +1,816,730 | 0.00 | 0.93 | +0.93 | buy |
| VANGUARD GROUP INC | 253,715 | 1,834,512 | +1,580,797 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 743,495 | +743,495 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 808,550 | +708,550 | 0.13 | 0.77 | +0.65 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 478,000 | +478,000 | 0.00 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 73,164 | 274,472 | +201,308 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 192,059 | +192,059 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 163,788 | +163,788 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 96,900 | +96,900 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 41 | 58,377 | +58,336 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 0 | 54,311 | +54,311 | 0.00 | 0.07 | +0.07 | buy |
| BML Capital Management, LLC | 100,000 | 150,000 | +50,000 | 0.48 | 0.61 | +0.13 | buy |
| DAFNA Capital Management LLC | 0 | 41,886 | +41,886 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 14,524 | 48,839 | +34,315 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 25,464 | 49,508 | +24,044 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 23,302 | +23,302 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 23,077 | +23,077 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 15,524 | +15,524 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 0 | 15,171 | +15,171 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 10,466 | +10,466 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,464 | 12,371 | +9,907 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 9,298 | +9,298 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 85,173 | 88,046 | +2,873 | 0.00 | 0.00 | -0.00 | buy |
| BFSG, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| FIRST MANHATTAN CO. LLC. | 0 | 333 | +333 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,449 | 2,449 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 88 | 88 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GPS Wealth Strategies Group, LLC | 8,441 | 8,441 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Commodore Capital LP | 1,575,000 | 1,575,000 | 0 | 0.96 | 0.71 | -0.26 | hold |
| TORONTO DOMINION BANK | 46 | 0 | -46 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,192 | 0 | -1,192 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 16,870 | 0 | -16,870 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,355 | 0 | -19,355 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 20,200 | 0 | -20,200 | 0.01 | 0.00 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 46,782 | 0 | -46,782 | 0.02 | 0.00 | -0.02 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 46,895 | 0 | -46,895 | 0.01 | 0.00 | -0.01 | sell |
| MYDA Advisors LLC | 50,000 | 0 | -50,000 | 0.10 | 0.00 | -0.10 | sell |
| GROUP ONE TRADING LLC | 75,305 | 0 | -75,305 | 0.02 | 0.00 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 138,500 | 0 | -138,500 | 0.01 | 0.00 | -0.01 | sell |
| Ikarian Capital, LLC | 229,100 | 0 | -229,100 | 0.45 | 0.00 | -0.45 | sell |