| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 920,000 | +920,000 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 26,394 | 88,951 | +62,557 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 16,877 | 60,082 | +43,205 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 35,000 | 70,429 | +35,429 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 14,605 | +14,605 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 4,217 | +4,217 | 0.00 | 0.00 | +0.00 | buy |
| Garde Capital, Inc. | 0 | 3,960 | +3,960 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 100 | 1,792 | +1,692 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 204,275 | 204,822 | +547 | 0.03 | 0.01 | -0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 18,139 | 18,469 | +330 | 0.41 | 0.17 | -0.25 | buy |
| COMERICA BANK | 56 | 155 | +99 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 594,282 | 594,282 | 0 | 0.46 | 0.19 | -0.27 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRIVATE TRUST CO NA | 42 | 42 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 89,191 | 89,191 | 0 | 0.06 | 0.02 | -0.04 | hold |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 619,981 | 619,981 | 0 | 3.53 | 20.42 | +16.89 | hold |
| Cable Car Capital, LP | 219,604 | 219,604 | 0 | 0.38 | 1.93 | +1.55 | hold |
| Ikarian Capital, LLC | 609,225 | 609,225 | 0 | 3.95 | 1.54 | -2.41 | hold |
| SBI Securities Co., Ltd. | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BlackRock, Inc. | 6,803 | 6,803 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REAP Financial Group, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| GROUP ONE TRADING LLC | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 2,103 | 0 | -2,103 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 3,784 | 0 | -3,784 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 600,000 | 593,088 | -6,912 | 0.28 | 0.11 | -0.17 | sell |
| PERCEPTIVE ADVISORS LLC | 95,742 | 0 | -95,742 | 0.06 | 0.00 | -0.06 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,133,944 | 910,609 | -223,335 | 0.12 | 0.04 | -0.08 | sell |