| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 1,000,682 | +1,000,682 | 0.00 | 2.00 | +2.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 333,333 | 950,000 | +616,667 | 0.01 | 0.04 | +0.02 | buy |
| MORGAN STANLEY | 70,531 | 500,298 | +429,767 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 233,369 | +233,369 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.21 | +0.21 | buy |
| LORD, ABBETT & CO. LLC | 0 | 114,635 | +114,635 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 36,297 | 150,307 | +114,010 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 91,772 | +91,772 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 246,685 | 337,983 | +91,298 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 0 | 84,803 | +84,803 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,914 | 133,494 | +80,580 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 12,916 | 73,651 | +60,735 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 58,020 | +58,020 | 0.00 | 0.29 | +0.29 | buy |
| JANE STREET GROUP, LLC | 0 | 57,933 | +57,933 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 32,187 | 85,969 | +53,782 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 310,965 | 340,695 | +29,730 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 29,491 | +29,491 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 25,706 | +25,706 | 0.00 | 0.05 | +0.05 | buy |
| Weil Company, Inc. | 0 | 24,765 | +24,765 | 0.00 | 0.14 | +0.14 | buy |
| Affinity Asset Advisors, LLC | 989,490 | 1,011,890 | +22,400 | 1.94 | 1.54 | -0.40 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 21,606 | +21,606 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 20,755 | +20,755 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 18,717 | +18,717 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 16,427 | +16,427 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 14,020 | +14,020 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 19,498 | 28,697 | +9,199 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 8,085 | 12,699 | +4,614 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 50,721 | 54,821 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 11,084 | 13,747 | +2,663 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 16,542 | 19,083 | +2,541 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 64,496 | 65,921 | +1,425 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 11,986 | 13,389 | +1,403 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 17,573 | 18,622 | +1,049 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 124,609 | 125,442 | +833 | 0.00 | 0.00 | -0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 496 | +496 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 76 | 478 | +402 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,196,955 | 1,196,955 | 0 | 0.67 | 0.68 | +0.01 | hold |
| FEDERATED HERMES, INC. | 1,765,516 | 1,765,516 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Cable Car Capital, LP | 400,000 | 400,000 | 0 | 0.68 | 3.58 | +2.90 | hold |
| Woodline Partners LP | 331,987 | 331,987 | 0 | 0.04 | 0.03 | -0.00 | hold |
| SBI Securities Co., Ltd. | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| REAP Financial Group, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 204 | 204 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ASSETMARK, INC | 58 | 46 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 28 | 0 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 553 | 493 | -60 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 10,289 | 10,200 | -89 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 773 | 0 | -773 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 185,869 | 184,984 | -885 | 1.06 | 0.82 | -0.24 | sell |
| CITIGROUP INC | 1,279 | 0 | -1,279 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 25,441 | 23,712 | -1,729 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 10,146 | 6,744 | -3,402 | 0.13 | 0.07 | -0.07 | sell |
| SIMPLEX TRADING, LLC | 6,015 | 2,312 | -3,703 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 24,824 | 20,450 | -4,374 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 60,800 | 54,174 | -6,626 | 0.06 | 0.06 | +0.00 | sell |
| BARCLAYS PLC | 24,111 | 13,268 | -10,843 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 15,472 | 3,436 | -12,036 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 68,023 | 53,473 | -14,550 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 15,600 | 0 | -15,600 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 15,804 | 0 | -15,804 | 0.03 | 0.00 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 31,808 | 15,509 | -16,299 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 18,804 | 0 | -18,804 | 0.03 | 0.00 | -0.03 | sell |
| 683 Capital Management, LLC | 40,000 | 20,000 | -20,000 | 0.09 | 0.05 | -0.04 | sell |
| AWM Investment Company, Inc. | 236,821 | 200,000 | -36,821 | 0.62 | 0.57 | -0.05 | sell |
| AMERIPRISE FINANCIAL INC | 153,027 | 111,788 | -41,239 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 300,000 | 118,972 | -181,028 | 1.06 | 0.44 | -0.62 | sell |
| Jain Global LLC | 202,433 | 15,597 | -186,836 | 0.05 | 0.01 | -0.05 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,460,971 | 1,273,965 | -187,006 | 0.16 | 0.14 | -0.01 | sell |
| JANUS HENDERSON GROUP PLC | 1,425,785 | 1,188,060 | -237,725 | 0.02 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 487,275 | 0 | -487,275 | 0.02 | 0.00 | -0.02 | sell |