| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 0 | 1,072,233 | +1,072,233 | 0.00 | 0.03 | +0.03 | buy |
| FRED ALGER MANAGEMENT, LLC | 910,609 | 1,618,649 | +708,040 | 0.04 | 0.09 | +0.05 | buy |
| ORBIMED ADVISORS LLC | 593,088 | 1,196,955 | +603,867 | 0.11 | 0.39 | +0.28 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 495,109 | +495,109 | 0.00 | 1.67 | +1.67 | buy |
| JANUS HENDERSON GROUP PLC | 920,000 | 1,394,852 | +474,852 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 88,951 | 486,919 | +397,968 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 333,333 | +333,333 | 0.00 | 0.01 | +0.01 | buy |
| Cable Car Capital, LP | 219,604 | 500,000 | +280,396 | 1.93 | 2.80 | +0.86 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 619,981 | 786,647 | +166,666 | 20.42 | 29.45 | +9.02 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 143,033 | +143,033 | 0.00 | 0.58 | +0.58 | buy |
| Woodline Partners LP | 204,822 | 331,987 | +127,165 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 68,192 | +68,192 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,605 | 72,116 | +57,511 | 0.00 | 0.00 | +0.00 | buy |
| Mink Brook Asset Management LLC | 0 | 38,893 | +38,893 | 0.00 | 0.44 | +0.44 | buy |
| BlackRock, Inc. | 6,803 | 33,695 | +26,892 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 18,856 | +18,856 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 4,217 | 16,897 | +12,680 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 60,082 | 64,110 | +4,028 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 42 | 192 | +150 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 155 | 157 | +2 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Garde Capital, Inc. | 3,960 | 3,960 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Newbridge Financial Services Group, Inc. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| REAP Financial Group, LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| GROUP ONE TRADING LLC | 104 | 104 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,792 | 0 | -1,792 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 594,282 | 588,344 | -5,938 | 0.19 | 0.27 | +0.08 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 18,469 | 0 | -18,469 | 0.17 | 0.00 | -0.17 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 89,191 | 58,637 | -30,554 | 0.02 | 0.02 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 70,429 | 0 | -70,429 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 609,225 | 476,443 | -132,782 | 1.54 | 2.04 | +0.50 | sell |