| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 65,921 | 1,222,862 | +1,156,941 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 920,000 | +920,000 | 0.00 | 0.47 | +0.47 | buy |
| Integral Health Asset Management, LLC | 150,000 | 675,000 | +525,000 | 0.21 | 0.59 | +0.38 | buy |
| Woodline Partners LP | 331,987 | 712,753 | +380,766 | 0.03 | 0.05 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 1,196,955 | 1,577,705 | +380,750 | 0.68 | 0.64 | -0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 125,442 | 473,280 | +347,838 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,765,516 | 2,110,516 | +345,000 | 0.07 | 0.06 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 337,983 | 655,199 | +317,216 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 233,369 | 547,415 | +314,046 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 111,788 | 418,891 | +307,103 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 274,500 | +274,500 | 0.00 | 0.44 | +0.44 | buy |
| STATE STREET CORP | 54,821 | 328,522 | +273,701 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 84,803 | 303,100 | +218,297 | 0.01 | 0.03 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,273,965 | 1,439,697 | +165,732 | 0.14 | 0.10 | -0.04 | buy |
| FMR LLC | 340,695 | 502,826 | +162,131 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 20,450 | 164,557 | +144,107 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,011,890 | 1,145,391 | +133,501 | 1.54 | 1.19 | -0.35 | buy |
| NORTHERN TRUST CORP | 23,712 | 150,887 | +127,175 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 108,347 | +108,347 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 114,635 | 210,442 | +95,807 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 184,984 | 249,693 | +64,709 | 0.82 | 0.76 | -0.06 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 47,043 | +47,043 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 47,043 | +47,043 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 40,930 | +40,930 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 29,947 | +29,947 | 0.00 | 0.01 | +0.01 | buy |
| AWM Investment Company, Inc. | 200,000 | 222,500 | +22,500 | 0.57 | 0.41 | -0.16 | buy |
| RHUMBLINE ADVISERS | 0 | 22,149 | +22,149 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 18,717 | 38,898 | +20,181 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 19,271 | +19,271 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 18,164 | +18,164 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 15,900 | +15,900 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 29,491 | 44,156 | +14,665 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,436 | 16,290 | +12,854 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 12,279 | +12,279 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 21,606 | 33,567 | +11,961 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 6,744 | 18,263 | +11,519 | 0.07 | 0.12 | +0.05 | buy |
| MetLife Investment Management, LLC | 0 | 11,471 | +11,471 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 9,102 | +9,102 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 8,880 | +8,880 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 8,041 | +8,041 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 8,000 | +8,000 | 0.00 | 0.01 | +0.01 | buy |
| MANGROVE PARTNERS IM, LLC | 25,706 | 33,346 | +7,640 | 0.05 | 0.05 | -0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,800 | +6,800 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 5,712 | +5,712 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,140 | +2,140 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,880 | +1,880 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,758 | +1,758 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 1,444 | +1,444 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 28,697 | 30,108 | +1,411 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 1,020 | +1,020 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 267 | +267 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 113 | +113 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 478 | 572 | +94 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Weil Company, Inc. | 24,765 | 24,765 | 0 | 0.14 | 0.09 | -0.05 | hold |
| Cable Car Capital, LP | 400,000 | 400,000 | 0 | 3.58 | 0.18 | -3.40 | hold |
| Steward Partners Investment Advisory, LLC | 493 | 493 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REAP Financial Group, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ASSETMARK, INC | 46 | 34 | -12 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 13,389 | 13,322 | -67 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 204 | 104 | -100 | 0.00 | 0.00 | -0.00 | sell |
| FIFTH THIRD BANCORP | 496 | 150 | -346 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 15,509 | 13,411 | -2,098 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,312 | 0 | -2,312 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 13,747 | 10,223 | -3,524 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 54,174 | 46,182 | -7,992 | 0.06 | 0.03 | -0.03 | sell |
| Squarepoint Ops LLC | 20,755 | 12,317 | -8,438 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 13,268 | 4,362 | -8,906 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 10,200 | 0 | -10,200 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 12,699 | 0 | -12,699 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 1,000,682 | 987,448 | -13,234 | 2.00 | 1.28 | -0.72 | sell |
| GOLDMAN SACHS GROUP INC | 53,473 | 40,160 | -13,313 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 14,020 | 0 | -14,020 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 15,597 | 0 | -15,597 | 0.01 | 0.00 | -0.01 | sell |
| Engineers Gate Manager LP | 16,427 | 0 | -16,427 | 0.01 | 0.00 | -0.01 | sell |
| Quadrature Capital Ltd | 18,622 | 0 | -18,622 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 19,083 | 0 | -19,083 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 20,000 | 0 | -20,000 | 0.05 | 0.00 | -0.05 | sell |
| Russell Investments Group, Ltd. | 91,772 | 70,409 | -21,363 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 57,933 | 20,805 | -37,128 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 73,651 | 25,168 | -48,483 | 0.01 | 0.00 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 58,020 | 0 | -58,020 | 0.29 | 0.00 | -0.29 | sell |
| Qube Research & Technologies Ltd | 85,969 | 0 | -85,969 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 118,972 | 20,972 | -98,000 | 0.44 | 0.07 | -0.37 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 133,494 | 0 | -133,494 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 150,307 | 0 | -150,307 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 700,000 | -250,000 | 0.04 | 0.02 | -0.02 | sell |
| MORGAN STANLEY | 500,298 | 0 | -500,298 | 0.00 | 0.00 | -0.00 | sell |