| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 1,072,233 | 1,635,380 | +563,147 | 0.03 | 0.04 | +0.02 | buy |
| AWM Investment Company, Inc. | 0 | 261,821 | +261,821 | 0.00 | 0.37 | +0.37 | buy |
| FMR LLC | 0 | 244,400 | +244,400 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 486,919 | 566,741 | +79,822 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 69,892 | +69,892 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 72,116 | 119,812 | +47,696 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 64,110 | 108,318 | +44,208 | 0.00 | 0.00 | +0.00 | buy |
| Mink Brook Asset Management LLC | 38,893 | 81,312 | +42,419 | 0.44 | 0.82 | +0.39 | buy |
| STATE STREET CORP | 0 | 38,097 | +38,097 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 23,285 | +23,285 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 19,165 | +19,165 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,618,649 | 1,636,030 | +17,381 | 0.09 | 0.10 | +0.00 | buy |
| BlackRock, Inc. | 33,695 | 50,662 | +16,967 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 16,200 | +16,200 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 11,253 | +11,253 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 10,765 | +10,765 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,394,852 | 1,403,842 | +8,990 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 18,856 | 23,347 | +4,491 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 820 | +820 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 553 | +553 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 162 | +162 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 192 | 274 | +82 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 81 | +81 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 12 | 13 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,196,955 | 1,196,955 | 0 | 0.39 | 0.43 | +0.04 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 333,333 | 333,333 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 786,647 | 786,647 | 0 | 29.45 | 38.15 | +8.70 | hold |
| Cable Car Capital, LP | 500,000 | 500,000 | 0 | 2.80 | 3.21 | +0.42 | hold |
| Woodline Partners LP | 331,987 | 331,987 | 0 | 0.02 | 0.02 | +0.00 | hold |
| REAP Financial Group, LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 104 | 104 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 157 | 150 | -7 | 0.00 | 0.00 | +0.00 | sell |
| Garde Capital, Inc. | 3,960 | 0 | -3,960 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 16,897 | 12,291 | -4,606 | 0.02 | 0.01 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 495,109 | 474,309 | -20,800 | 1.67 | 1.69 | +0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 58,637 | 0 | -58,637 | 0.02 | 0.00 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 68,192 | 0 | -68,192 | 0.03 | 0.00 | -0.03 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 143,033 | 0 | -143,033 | 0.58 | 0.00 | -0.58 | sell |
| Ikarian Capital, LLC | 476,443 | 300,000 | -176,443 | 2.04 | 0.91 | -1.13 | sell |
| BVF INC/IL | 588,344 | 65,350 | -522,994 | 0.27 | 0.04 | -0.23 | sell |