| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FRED ALGER MANAGEMENT, LLC | 82,698 | 1,133,944 | +1,051,246 | 0.00 | 0.12 | +0.12 | buy |
| Ikarian Capital, LLC | 0 | 609,225 | +609,225 | 0.00 | 3.95 | +3.95 | buy |
| ORBIMED ADVISORS LLC | 0 | 600,000 | +600,000 | 0.00 | 0.28 | +0.28 | buy |
| BVF INC/IL | 119,282 | 594,282 | +475,000 | 0.02 | 0.46 | +0.44 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 144,981 | 619,981 | +475,000 | 0.23 | 3.53 | +3.31 | buy |
| Woodline Partners LP | 0 | 204,275 | +204,275 | 0.00 | 0.03 | +0.03 | buy |
| Cable Car Capital, LP | 81,279 | 219,604 | +138,325 | 0.49 | 0.38 | -0.11 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 89,191 | +89,191 | 0.00 | 0.06 | +0.06 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 18,139 | +18,139 | 0.00 | 0.41 | +0.41 | buy |
| ROYAL BANK OF CANADA | 0 | 3,784 | +3,784 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 14,270 | 16,877 | +2,607 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 2,103 | +2,103 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 56 | +56 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 0 | 42 | +42 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 26,394 | 26,394 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 95,742 | 95,742 | 0 | 0.01 | 0.06 | +0.05 | hold |
| BlackRock, Inc. | 6,803 | 6,803 | 0 | 0.00 | 0.00 | +0.00 | hold |
| REAP Financial Group, LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 7 | 7 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 18 | 0 | -18 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 559 | 104 | -455 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 806 | 100 | -706 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 6,000 | 0 | -6,000 | 0.01 | 0.00 | -0.01 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 72,413 | 35,000 | -37,413 | 0.00 | 0.00 | +0.00 | sell |
| BML Capital Management, LLC | 70,468 | 0 | -70,468 | 0.23 | 0.00 | -0.23 | sell |