| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | 1,549,850 | +1,549,850 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 2,057,200 | 3,107,200 | +1,050,000 | 0.29 | 0.35 | +0.06 | buy |
| CITADEL ADVISORS LLC | 0 | 956,429 | +956,429 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 121,286 | 620,602 | +499,316 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 412,725 | +412,725 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 290,413 | +290,413 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 200,212 | +200,212 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 193,638 | +193,638 | 0.00 | 0.08 | +0.08 | buy |
| Walleye Capital LLC | 198,375 | 388,554 | +190,179 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 222,610 | 387,567 | +164,957 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 740,000 | 904,268 | +164,268 | 0.24 | 0.25 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 106,000 | 226,000 | +120,000 | 0.03 | 0.05 | +0.02 | buy |
| BlackRock, Inc. | 42,727 | 131,215 | +88,488 | 0.00 | 0.00 | +0.00 | buy |
| NOESIS CAPITAL MANGEMENT CORP | 224,200 | 311,500 | +87,300 | 0.06 | 0.09 | +0.02 | buy |
| STATE STREET CORP | 72,899 | 141,199 | +68,300 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 68,076 | +68,076 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 405,531 | 469,878 | +64,347 | 0.06 | 0.05 | -0.00 | buy |
| NORTHERN TRUST CORP | 40,314 | 77,324 | +37,010 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 37,014 | 62,451 | +25,437 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 11,402 | +11,402 | 0.00 | 0.02 | +0.02 | buy |
| Headlands Technologies LLC | 0 | 10,950 | +10,950 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 10,822 | +10,822 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 431 | 638 | +207 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 254,412 | 254,412 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 957,062 | 957,062 | 0 | 0.24 | 0.26 | +0.02 | hold |
| SOA Wealth Advisors, LLC. | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 22 | 22 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Activest Wealth Management | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 1,953,467 | 1,953,467 | 0 | 0.10 | 0.10 | -0.01 | hold |
| BARCLAYS PLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 91 | 0 | -91 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 12,491 | 12,180 | -311 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,380 | 0 | -1,380 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 21,500 | 20,000 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,046 | 1,373 | -3,673 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 39,585 | 0 | -39,585 | 0.04 | 0.00 | -0.04 | sell |
| TWO SIGMA INVESTMENTS, LP | 456,333 | 408,858 | -47,475 | 0.00 | 0.00 | -0.00 | sell |
| Mountain Capital Investment Advisors Inc. | 63,000 | 0 | -63,000 | 0.02 | 0.00 | -0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,096,179 | 1,010,955 | -85,224 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 108,400 | 0 | -108,400 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 160,000 | 0 | -160,000 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 242,076 | 0 | -242,076 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 274,862 | 0 | -274,862 | 0.30 | 0.00 | -0.30 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 353,339 | 0 | -353,339 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 584,368 | 0 | -584,368 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 2,228,000 | 1,583,000 | -645,000 | 0.20 | 0.13 | -0.07 | sell |
| Logos Global Management LP | 2,000,000 | 1,300,000 | -700,000 | 0.26 | 0.13 | -0.13 | sell |