| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 0 | 3,570,000 | +3,570,000 | 0.00 | 0.32 | +0.32 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 226,000 | 3,520,490 | +3,294,490 | 0.05 | 0.69 | +0.64 | buy |
| Vestal Point Capital, LP | 0 | 2,600,000 | +2,600,000 | 0.00 | 0.11 | +0.11 | buy |
| Ensign Peak Advisors, Inc | 0 | 1,832,457 | +1,832,457 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 1,776,547 | +1,776,547 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 3,107,200 | 4,007,881 | +900,681 | 0.35 | 0.34 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 290,413 | 1,121,492 | +831,079 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 498,872 | +498,872 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 956,429 | 1,384,029 | +427,600 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 390,147 | +390,147 | 0.00 | 0.88 | +0.88 | buy |
| MARSHALL WACE, LLP | 620,602 | 904,132 | +283,530 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 202,847 | +202,847 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,010,955 | 1,170,893 | +159,938 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 387,567 | 500,816 | +113,249 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 388,554 | 500,375 | +111,821 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 131,215 | 242,016 | +110,801 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,549,850 | 1,651,473 | +101,623 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 0 | 101,557 | +101,557 | 0.00 | 0.02 | +0.02 | buy |
| NOESIS CAPITAL MANGEMENT CORP | 311,500 | 405,000 | +93,500 | 0.09 | 0.09 | -0.00 | buy |
| Headlands Technologies LLC | 10,950 | 47,413 | +36,463 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 77,324 | 111,319 | +33,995 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 141,199 | 170,799 | +29,600 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 16,151 | +16,151 | 0.00 | 0.00 | +0.00 | buy |
| Spark Investment Management LLC | 0 | 13,500 | +13,500 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 0 | 10,637 | +10,637 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 3,255 | +3,255 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 22 | 42 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 2 | 9 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Financial Gravity Companies, Inc. | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 904,268 | 904,268 | 0 | 0.25 | 0.27 | +0.02 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 254,412 | 254,412 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ikarian Capital, LLC | 957,062 | 957,062 | 0 | 0.26 | 0.27 | +0.01 | hold |
| SOA Wealth Advisors, LLC. | 13 | 13 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 1,953,467 | 1,953,467 | 0 | 0.10 | 0.07 | -0.02 | hold |
| Steward Partners Investment Advisory, LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 638 | 431 | -207 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 1,373 | 0 | -1,373 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 62,451 | 57,842 | -4,609 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 408,858 | 400,667 | -8,191 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 10,822 | 0 | -10,822 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 11,402 | 0 | -11,402 | 0.02 | 0.00 | -0.02 | sell |
| Vanguard Personalized Indexing Management, LLC | 12,180 | 0 | -12,180 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 193,638 | 170,053 | -23,585 | 0.08 | 0.06 | -0.03 | sell |
| Lynx1 Capital Management LP | 68,076 | 0 | -68,076 | 0.02 | 0.00 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 469,878 | 375,531 | -94,347 | 0.05 | 0.03 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 200,212 | 0 | -200,212 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 412,725 | 0 | -412,725 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 1,300,000 | 0 | -1,300,000 | 0.13 | 0.00 | -0.13 | sell |
| EcoR1 Capital, LLC | 1,583,000 | 0 | -1,583,000 | 0.13 | 0.00 | -0.13 | sell |