| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 2,228,000 | +2,228,000 | 0.00 | 0.20 | +0.20 | buy |
| Affinity Asset Advisors, LLC | 0 | 2,057,200 | +2,057,200 | 0.00 | 0.29 | +0.29 | buy |
| Logos Global Management LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.26 | +0.26 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,953,467 | +1,953,467 | 0.00 | 0.10 | +0.10 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 10,400 | 1,096,179 | +1,085,779 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 740,000 | +740,000 | 0.00 | 0.24 | +0.24 | buy |
| VANGUARD GROUP INC | 274,070 | 883,149 | +609,079 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 456,333 | +456,333 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 27,000 | 405,531 | +378,531 | 0.00 | 0.06 | +0.06 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 353,339 | +353,339 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 617,327 | 957,062 | +339,735 | 0.10 | 0.24 | +0.14 | buy |
| Monashee Investment Management LLC | 0 | 274,862 | +274,862 | 0.00 | 0.30 | +0.30 | buy |
| Hudson Bay Capital Management LP | 0 | 242,076 | +242,076 | 0.00 | 0.00 | +0.00 | buy |
| NOESIS CAPITAL MANGEMENT CORP | 0 | 224,200 | +224,200 | 0.00 | 0.06 | +0.06 | buy |
| Walleye Capital LLC | 0 | 198,375 | +198,375 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 160,000 | +160,000 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 121,286 | +121,286 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 108,400 | +108,400 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 106,000 | +106,000 | 0.00 | 0.03 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 482,300 | 584,368 | +102,068 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 176,862 | 254,412 | +77,550 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 151,309 | 222,610 | +71,301 | 0.00 | 0.00 | +0.00 | buy |
| Mountain Capital Investment Advisors Inc. | 0 | 63,000 | +63,000 | 0.00 | 0.02 | +0.02 | buy |
| Persistent Asset Partners Ltd | 0 | 39,585 | +39,585 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 33,699 | 72,899 | +39,200 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 37,014 | +37,014 | 0.00 | 0.00 | +0.00 | buy |
| PFG Investments, LLC | 0 | 21,500 | +21,500 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 23,044 | 40,314 | +17,270 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 12,491 | +12,491 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 5,046 | +5,046 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 431 | +431 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Motiv8 Investments LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 91 | 91 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SOA Wealth Advisors, LLC. | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 22 | 22 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Activest Wealth Management | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BlackRock, Inc. | 42,727 | 42,727 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITY HOLDING CO | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,733 | 1,380 | -353 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 34,157 | 0 | -34,157 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 41,900 | 0 | -41,900 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 45,079 | 0 | -45,079 | 0.01 | 0.00 | -0.01 | sell |
| Opaleye Management Inc. | 375,000 | 0 | -375,000 | 0.04 | 0.00 | -0.04 | sell |
| Lynx1 Capital Management LP | 1,055,897 | 0 | -1,055,897 | 0.18 | 0.00 | -0.18 | sell |