| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FRANKLIN RESOURCES INC | 0 | 938,666 | +938,666 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 892,074 | +892,074 | 0.00 | 0.14 | +0.14 | buy |
| Vivo Capital, LLC | 0 | 813,666 | +813,666 | 0.00 | 0.38 | +0.38 | buy |
| Point72 Asset Management, L.P. | 0 | 690,778 | +690,778 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 500,432 | +500,432 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 489,207 | +489,207 | 0.00 | 0.47 | +0.47 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 475,000 | +475,000 | 0.00 | 0.07 | +0.07 | buy |
| Soleus Capital Management, L.P. | 0 | 414,359 | +414,359 | 0.00 | 0.09 | +0.09 | buy |
| Avidity Partners Management LP | 0 | 387,769 | +387,769 | 0.00 | 0.44 | +0.44 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 380,354 | +380,354 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.36 | +0.36 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 298,433 | +298,433 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 230,833 | +230,833 | 0.00 | 0.12 | +0.12 | buy |
| ADAR1 Capital Management, LLC | 0 | 222,555 | +222,555 | 0.00 | 0.08 | +0.08 | buy |
| Stonepine Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.50 | +0.50 | buy |
| HRT FINANCIAL LP | 0 | 30,461 | +30,461 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 16,245 | +16,245 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 12,000 | +12,000 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 11,907 | +11,907 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 10,145 | +10,145 | 0.00 | 0.04 | +0.04 | buy |
| AXQ CAPITAL, LP | 0 | 10,096 | +10,096 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 6,400 | +6,400 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,115 | +2,115 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |