| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Stonepine Capital Management, LLC | 100,000 | 491,624 | +391,624 | 0.50 | 2.83 | +2.34 | buy |
| AWM Investment Company, Inc. | 0 | 180,000 | +180,000 | 0.00 | 0.12 | +0.12 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 489,207 | 652,590 | +163,383 | 0.47 | 0.73 | +0.25 | buy |
| CITADEL ADVISORS LLC | 0 | 67,738 | +67,738 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,400 | 20,000 | +13,600 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 11,907 | 11,907 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 683 Capital Management, LLC | 230,833 | 230,833 | 0 | 0.12 | 0.17 | +0.04 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 475,000 | 475,000 | 0 | 0.07 | 0.08 | +0.01 | hold |
| Vivo Capital, LLC | 813,666 | 813,666 | 0 | 0.38 | 0.58 | +0.20 | hold |
| Woodline Partners LP | 500,432 | 500,432 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Avidity Partners Management LP | 387,769 | 387,769 | 0 | 0.44 | 0.48 | +0.04 | hold |
| ADAR1 Capital Management, LLC | 222,555 | 222,555 | 0 | 0.08 | 0.08 | +0.01 | hold |
| Caitong International Asset Management Co., Ltd | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Saturn V Capital Management LP | 350,000 | 350,000 | 0 | 0.36 | 0.39 | +0.03 | hold |
| Siren, L.L.C. | 892,074 | 892,074 | 0 | 0.14 | 0.14 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 19 | 19 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 938,666 | 938,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 140 | 0 | -140 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 16,245 | 15,863 | -382 | 0.00 | 0.00 | +0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 2,115 | 0 | -2,115 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 690,778 | 682,700 | -8,078 | 0.01 | 0.01 | +0.00 | sell |
| AXQ CAPITAL, LP | 10,096 | 0 | -10,096 | 0.01 | 0.00 | -0.01 | sell |
| Propel Bio Management, LLC | 10,145 | 0 | -10,145 | 0.04 | 0.00 | -0.04 | sell |
| Monashee Investment Management LLC | 12,000 | 0 | -12,000 | 0.04 | 0.00 | -0.04 | sell |
| HRT FINANCIAL LP | 30,461 | 0 | -30,461 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 414,359 | 314,359 | -100,000 | 0.09 | 0.08 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 298,433 | 152,768 | -145,665 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 380,354 | 150,000 | -230,354 | 0.00 | 0.00 | -0.00 | sell |